TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

Deliverables

Transcriptomic, immunomic and metabolic correlates of TB infection

Transcriptomic, immunomic and metabolic correlates of TB infection, vaccine induced immunity and protection (M48)

Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART

Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART; and identify potential biomarkers of reduced susceptibility to TB, incl. diagnostic and prognostic protein biomarkers in plasma (M30)

Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles

Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles (cytokine, chemokine and cytotoxic molecule expression, memory, activation and homing markers, chemokine receptors, etc) in M.tbuninfected, M.tb-infected (latent), TB diseased and in vaccinated persons (M48)

List of the autophagic and miRNA markers analyzed and correlatio

List of the autophagic and miRNA markers analyzed and correlation with TB clinical outcome (M48)

Global TB vaccine meeting

Organization of global vaccine meeting (M10)

Bioinformatic signature validation and data integration

Bioinformatic signature validation and data integration. Pathway analysis of long term non-progressor Signatures (M48)

Validate biomarkers that predict the development of active TB in HIV infected persons

Validate biomarkers that predict the development of active TB in HIV infected persons will be validated in a second set of plasma (M42)

Targeted Luminex analysis to define M.tb-specific soluble host bio-signatures

Targeted Luminex analysis to define M.tb-specific soluble host bio-signatures from subjects with different TB/HIV infection phenotypes that can be used for identification of ‘at-risk’ subjects. Samples from minimally 3- sites (Gambia, S. Africa, Malawi) (M36)

Detection of cytotoxic and bactericidal molecules intracellularly a

Detection of cytotoxic and bactericidal molecules intracellularly and in stimulated plasma by ELISA/Luminex in patients before and during therapy (M48)

Discovery Luminex analysis define key antigen-analyte and dcRT-MLPA RNA analysis combinations

Discovery Luminex analysis using Gambian and S. African subjects to define key antigen-analyte and dcRT-MLPA RNA analysis combinations (M18)

head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA

Data on head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA for the measurement of correlates of protection against TB (M48)

Data from measurements of selected immune mediators

Data from measurements of selected immune mediators (including epigenetic modifiers of immune responses and associated infant cellular responses) in UK and Ugandan infants as well as the effect of BCG vaccination on these mediators (M48)

Identification of a repertoire of surface molecules on NK cells and DC subsets and related cytokines associated with latent versus active TB

Identification of a repertoire of surface molecules on NK cells and DC subsets and of related cytokines associated with latency versus active TB (M36)

Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants

Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants (M.tb antigen specific marker production in whole blood, RNA sequencing, metabolomics and miRNA expression) (M48)

3 Annual project meetings

Annual project meetings (TBVI; M14, M26, M38)

Identification of transcriptomic biomarkers predictive of an efficient immune response

Identification of transcriptomic biomarkers predictive of an efficient immune response to MTBVAC vs. BCG (M24)

Identification of potential immune correlates from the human mycobacterial challenge model

report on Identification of potential immune correlates from the human mycobacterial challenge model

Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells

Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells, macrophage subsets and plasma chemokines and cytokines in patients with M.tb or M.tb/HIV co-infection, before, during and after treatment (M48)

Combination of HBHA and adjuvant has been selected

publication on HBHA adjuvant selection

A first version TB Biomarker data base

A first version TB Biomarker data base for tailor made selection of assays for specific trials and studies (M48)

Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infection”

(M48) Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infection”

Collection of samples from S. Korean LTBI cohort

Collection of samples (plasma/serum, QFT supernatants/blood clots, WBA supernatants, RNA and mRNA PAXgene tubes) from S. Korean LTBI cohort. (M24) and Testing of biomarkers using standardized assay protocols on samples from S. Korean LTBI cohort (M42)

RNA expression correlate of functional

RNA expression correlate of functional (whole blood killing) immune responses to M.tb infection, BCG or novel TB vaccines (M36)

Correlates of risk for, and protection from, active TB

Correlates of risk for, and protection from, active TB based on host markers produced in response to M.tb infection stage specific proteins (M40)

correlation of hematopoietic progenitor cell populations

Report on correlation of hematopoietic progenitor cell populations with vaccine immunogenicity and risk of TB disease (M24)

Transcriptome analyses of approx. 700 microarrays of Belarus cohort

Transcriptome analyses of approx. 700 microarrays of Belarus cohort completed; dData analysis and validation with qPCR completed. First cell specific biosignatures identified in Belarus

Systems biology analysis to define biosignatures of protection to latent TB

Systems biology analysis to define biosignatures of protection to latent TB using TB exposed but persistently TST negative subjects (combined metabolomics, RNA-seq) (M36)

Cohort data base and related specimen bank collection

Cohort data base and related specimen bank collection. Four hundred HIV-infected and uninfected subjects either with LTBI, active TB followed during treatment and controls no M.tb-infected will be enrolled (M30)

Fully optimized protocols for isolation and ICS characterization of Suction Blister

Fully optimized protocols for isolation and ICS characterization of Suction Blister Mononuclear Cells and SBMC based MGIA (M2412)

Identification of a signature that distinguishes long term non- progressors from recently infected individuals

Identification of a signature that distinguishes long term non- progressors from recently infected individuals, and validation in second cohort(M48)

Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and human

Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and humans immunized with live- and lipid-based vaccines with the outcome of vaccination (M48)

Establish Portfolio management committee

Establish PMC and processes and implementation of portfolio management approach (M8)

Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial

Report with data of Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial in samples from subsequent clinical trials with optimised immunisation regimes

Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bank

Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bank containing mRNA and supernatants from bronchoalveolar lavage cells and blood from the German study cohort “TB-or-not-TB”. (M36)

Project website established

Publications

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung

Author(s): J S Woodworth, S B Cohen, A O Moguche, C R Plumlee, E M Agger, K B Urdahl, P Andersen
Published in: Mucosal Immunology, Issue 10/2, 2016, Page(s) 555-564, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/mi.2016.70

What Have We Learnt about BCG Vaccination in the Last 20 Years?

Author(s): Hazel M. Dockrell, Steven G. Smith
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01134

Rapid Quantification and Validation of Lipid Concentrations within Liposomes

Author(s): Carla Roces, Elisabeth Kastner, Peter Stone, Deborah Lowry, Yvonne Perrie
Published in: Pharmaceutics, Issue 8/4, 2016, Page(s) 29, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics8030029

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

Author(s): Steven G. Smith, Kaatje Smits, Simone A. Joosten, Krista E. van Meijgaarden, Iman Satti, Helen A. Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M. Dockrell, Tom H. M. Ottenhoff
Published in: PLOS ONE, Issue 10/9, 2015, Page(s) e0138042, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0138042

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Author(s): Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I. Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J. Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
Published in: PLOS Pathogens, Issue 12/7, 2016, Page(s) e1005770, ISSN 1553-7374
Publisher: PLos Pathogans
DOI: 10.1371/journal.ppat.1005770

The SysteMHC Atlas project

Author(s): Wenguang Shao, Patrick G A Pedrioli, Witold Wolski, Cristian Scurtescu, Emanuel Schmid, Juan A Vizcaíno, Mathieu Courcelles, Heiko Schuster, Daniel Kowalewski, Fabio Marino, Cecilia S L Arlehamn, Kerrie Vaughan, Bjoern Peters, Alessandro Sette, Tom H M Ottenhoff, Krista E Meijgaarden, Natalie Nieuwenhuizen, Stefan H E Kaufmann, Ralph Schlapbach, John C Castle, Alexey I Nesvizhskii, Morten Niel
Published in: Nucleic Acids Research, Issue 46/D1, 2017, Page(s) D1237-D1247, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx664

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis

Author(s): Hermann Giresse Tima, Juma''a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
Published in: Journal of Innate Immunity, Issue 9/2, 2017, Page(s) 162-180, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000450955

A method permissive to fixation and permeabilization for the multiparametric analysis of apoptotic and necrotic cell phenotype by flow cytometry

Author(s): Sabrina Mariotti, Manuela Pardini, Raffaela Teloni, Maria Cristina Gagliardi, Maurizio Fraziano, Roberto Nisini
Published in: Cytometry Part A, Issue 91/11, 2017, Page(s) 1115-1124, ISSN 1552-4922
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23268

Breaking Transmission with Vaccines: The Case of Tuberculosis

Author(s): Jesus Gonzalo-Asensio, Nacho Aguilo, Dessislava Marinova, Carlos Martin
Published in: Microbiology Spectrum, Issue 5/4, 2017, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/microbiolspec.MTBP-0001-2016

Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

Author(s): Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-02116-1

Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

Author(s): Ans De Beuckelaer, Johan Grooten, Stefaan De Koker
Published in: Trends in Molecular Medicine, Issue 23/3, 2017, Page(s) 216-226, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2017.01.006

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

Author(s): Andrea Zelmer, Rachel Tanner, Elena Stylianou, Timon Damelang, Sheldon Morris, Angelo Izzo, Ann Williams, Sally Sharpe, Ilaria Pepponi, Barry Walker, David A. Hokey, Helen McShane, Michael Brennan, Helen Fletcher
Published in: BMC Infectious Diseases, Issue 16/1, 2016, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-016-1751-4

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

Author(s): Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Published in: PLOS ONE, Issue 12/2, 2017, Page(s) e0171358, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0171358

Application of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System

Author(s): Raj Badhan, Swapnil Khadke, Yvonne Perrie
Published in: Pharmaceutics, Issue 9/4, 2017, Page(s) 57, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics9040057

The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010–2014

Author(s): Michael J. Brennan, Rachel Tanner, Sheldon Morris, Thomas J. Scriba, Jacqueline M. Achkar, Andrea Zelmer, David A. Hokey, Angelo Izzo, Sally Sharpe, Ann Williams, Adam Penn-Nicholson, Mzwandile Erasmus, Elena Stylianou, Daniel F. Hoft, Helen McShane, Helen A. Fletcher
Published in: Clinical and Vaccine Immunology, Issue 24/9, 2017, Page(s) e00142-17, ISSN 1556-6811
Publisher: American Society for Microbiology
DOI: 10.1128/CVI.00142-17

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

Author(s): Jesus Gonzalo-Asensio, Dessislava Marinova, Carlos Martin, Nacho Aguilo
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01803

T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties

Author(s): Thomas Lindenstrøm, Albanus Moguche, Mie Damborg, Else Marie Agger, Kevin Urdahl, Peter Andersen
Published in: EBioMedicine, Issue 27, 2018, Page(s) 27-39, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2017.12.004

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

Author(s): Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin
Published in: Nature Communications, Issue 8, 2017, Page(s) 16085, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms16085

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

Author(s): Sameer Joshi, Maryam T. Hussain, Carla B. Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J. Kirby, Yvonne Perrie
Published in: International Journal of Pharmaceutics, Issue 514/1, 2016, Page(s) 160-168, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.09.027

Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study

Author(s): Helen A. Fletcher, Ali Filali-Mouhim, Elisa Nemes, Anthony Hawkridge, Alana Keyser, Samuel Njikan, Mark Hatherill, Thomas J. Scriba, Brian Abel, Benjamin M. Kagina, Ashley Veldsman, Nancy Marín Agudelo, Gilla Kaplan, Gregory D. Hussey, Rafick-Pierre Sekaly, Willem A. Hanekom
Published in: BMC Medicine, Issue 14/1, 2016, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-016-0617-3

Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance

Author(s): Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Published in: Scientific Reports, Issue 7, 2017, Page(s) 45120, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep45120

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

Author(s): Steven G. Smith, Andrea Zelmer, Rose Blitz, Helen A. Fletcher, Hazel M. Dockrell
Published in: Vaccine, Issue 34/44, 2016, Page(s) 5298-5305, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2016.09.002

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

Author(s): Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Brij, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01203

Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation

Author(s): Steven G. Smith, Johanneke Kleinnijenhuis, Mihai G. Netea, Hazel M. Dockrell
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.00644

Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis

Author(s): Alexandra Dreesman, Véronique Corbière, Violette Dirix, Kaat Smits, Sara Debulpaep, Iris De Schutter, Myriam Libin, Mahavir Singh, Anne Malfroot, Camille Locht, Françoise Mascart
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01059

T-cell activation is an immune correlate of risk in BCG vaccinated infants

Author(s): Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson, Elisa Nemes, Mark Hatheril,
Published in: Nature Communications, Issue 7, 2016, Page(s) 11290, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms11290

Mycobacterium tuberculosis -associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

Author(s): Muriel Smet, Charlotte Pollard, Ans De Beuckelaer, Lien Van Hoecke, Seppe Vander Beken, Stefaan De Koker, Juma'a R. Al Dulayymi, Kris Huygen, Jan Verschoor, Mark S. Baird, Johan Grooten
Published in: European Journal of Immunology, Issue 46/9, 2016, Page(s) 2149-2154, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646357

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Author(s): Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy, Stefaan De Koker
Published in: Advanced Healthcare Materials, Issue 6/13, 2017, Page(s) 1601412, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201601412

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries

Author(s): Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin
Published in: Expert Review of Vaccines, Issue 16/6, 2017, Page(s) 565-576, ISSN 1476-0584
Publisher: Future Drugs Ltd.
DOI: 10.1080/14760584.2017.1324303

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells

Author(s): Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Published in: European Journal of Immunology, Issue 48/2, 2018, Page(s) 293-305, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747184

Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity

Author(s): Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E. Kirwan, Hannah Steinberg, Robert H. Gilman, Emanuel F. Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
Published in: Science Translational Medicine, Issue 9/420, 2017, Page(s) eaal2807, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aal2807

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Author(s): Rachel Tanner, Matthew K. O’Shea, Andrew D. White, Julius Müller, Rachel Harrington-Kandt, Magali Matsumiya, Mike J. Dennis, Eneida A. Parizotto, Stephanie Harris, Elena Stylianou, Vivek Naranbhai, Paulo Bettencourt, Hal Drakesmith, Sally Sharpe, Helen A. Fletcher, Helen McShane
Published in: Scientific Reports, Issue 7, 2017, Page(s) 43478, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43478

A Case for a Human Immuno-Peptidome Project Consortium

Author(s): Etienne Caron, Ruedi Aebersold, Amir Banaei-Esfahani, Chloe Chong, Michal Bassani-Sternberg
Published in: Immunity, Issue 47/2, 2017, Page(s) 203-208, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2017.07.010

Novel approaches to tuberculosis vaccine development

Author(s): Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn
Published in: International Journal of Infectious Diseases, Issue 56, 2017, Page(s) 263-267, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2016.10.018

Functionally diverse human T cells recognize non-microbial antigens presented by MR1

Author(s): Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.24476

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

Author(s): Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, Andre Kubler, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Bruno B. Andrade
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.00542

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Author(s): Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Published in: Cell Reports, Issue 18/11, 2017, Page(s) 2752-2765, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.02.057

Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals

Author(s): Catherine Riou, Natacha Berkowitz, Rene Goliath, Wendy A. Burgers, Robert J. Wilkinson
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.00968

The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing

Author(s): Natalie E. Nieuwenhuizen, Prasad S. Kulkarni, Umesh Shaligram, Mark F. Cotton, Cyrill A. Rentsch, Bernd Eisele, Leander Grode, Stefan H. E. Kaufmann
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2017.01147

Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection

Author(s): Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Warwick J. Britton, Nikolai Petrovsky, James A. Triccas
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-09119-y

Novel vaccination approaches to prevent tuberculosis in children

Author(s): James A. Triccas, Claudio Counoupas
Published in: Pneumonia, Issue 8/1, 2016, ISSN 2200-6133
Publisher: Biomed Central
DOI: 10.1186/s41479-016-0020-z

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

Author(s): Ekta Lachmandas, Macarena Beigier-Bompadre, Shih-Chin Cheng, Vinod Kumar, Arjan van Laarhoven, Xinhui Wang, Anne Ammerdorffer, Lily Boutens, Dirk de Jong, Thirumala-Devi Kanneganti, Mark S. Gresnigt, Tom H.M. Ottenhoff, Leo A.B. Joosten, Rinke Stienstra, Cisca Wijmenga, Stefan H.E. Kaufmann, Reinout van Crevel, Mihai G. Netea
Published in: European Journal of Immunology, Issue 46/11, 2016, Page(s) 2574-2586, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546259

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers

Author(s): January Weiner, Stefan H.E. Kaufmann
Published in: International Journal of Infectious Diseases, Issue 56, 2017, Page(s) 258-262, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2016.10.017

From Immunologically Archaic to Neoteric Glycovaccines

Author(s): Marco Cavallari, Gennaro De Libero
Published in: Vaccines, Issue 5/4, 2017, Page(s) 4, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines5010004

Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis

Author(s): Natalie Zimmermann, Verena Thormann, Bo Hu, Anne‐Britta Köhler, Aki Imai‐Matsushima, Camille Locht, Eusondia Arnett, Larry S Schlesinger, Thomas Zoller, Mariana Schürmann, Stefan HE Kaufmann, Hedda Wardemann
Published in: EMBO Molecular Medicine, Issue 8/11, 2016, Page(s) 1325-1339, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201606330

Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition

Author(s): Inmaculada Yruela, Bruno Contreras-Moreira, Carlos Magalhães, Nuno S. Osório, Jesús Gonzalo-Asensio
Published in: Genome Biology and Evolution, 2017, Page(s) evw279, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evw279

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

Author(s): Daniel E Zak, Adam Penn-Nicholson, Thomas J Scriba, Ethan Thompson, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, Gregory D Hussey, Deborah Abrahams, Fazlin Kafaar, Tony Hawkridge, Suzanne Verver, E Jane Hughes, Martin Ota, Jayne Sutherland, Rawleigh Howe, Hazel M Dockrell, W Henry Boom, Bonnie Thiel, Tom H M Ottenhoff, Harriet Mayanja-Kizza, Amelia C Crampin, Katrin
Published in: The Lancet, Issue 387/10035, 2016, Page(s) 2312-2322, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(15)01316-1

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

Author(s): Mariateresa Coppola, Krista E. van Meijgaarden, Kees L. M. C. Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K. Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J. F. van den Eeden, Gro E. Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H. M. Ottenhoff
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep37793

Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines

Author(s): Hermann Giresse Tima, Kris Huygen, Marta Romano
Published in: Expert Review of Vaccines, Issue 15/11, 2016, Page(s) 1409-1420, ISSN 1476-0584
Publisher: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1187067

High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

Author(s): Rolf Billeskov, Thomas Lindenstrøm, Joshua Woodworth, Cristina Vilaplana, Pere-Joan Cardona, Joseph P. Cassidy, Rasmus Mortensen, Else Marie Agger, Peter Andersen
Published in: Frontiers in Immunology, Issue 8, 2018, ISSN 1664-3224
Publisher: Front. Immunol
DOI: 10.3389/fimmu.2017.01973

Reprogramming the T Cell Response to Tuberculosis

Author(s): Joshua S. Woodworth, Peter Andersen
Published in: Trends in Immunology, Issue 37/2, 2016, Page(s) 81-83, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2015.12.009

Protein Energy Malnutrition during Vaccination Has Limited Influence on Vaccine Efficacy but Abolishes Immunity if Administered during Mycobacterium tuberculosis Infection

Author(s): Truc Hoang, Else Marie Agger, Joseph P. Cassidy, Jan P. Christensen, Peter Andersen
Published in: Infection and Immunity, Issue 83/5, 2015, Page(s) 2118-2126, ISSN 0019-9567
Publisher: American Society for Microbiology
DOI: 10.1128/IAI.03030-14

Liposomal delivery of lipoarabinomannan triggers Mycobacterium tuberculosis specific T-cells

Author(s): Stephanie Kallert, Sebastian F. Zenk, Paul Walther, Mark Grieshober, Tanja Weil, Steffen Stenger
Published in: Tuberculosis, Issue 95/4, 2015, Page(s) 452-462, ISSN 1472-9792
Publisher: Churchill Livingstone
DOI: 10.1016/j.tube.2015.04.001

Molecular signatures for vaccine development

Author(s): J. Maertzdorf, S.H.E. Kaufmann, J. Weiner
Published in: Vaccine, Issue 33/40, 2015, Page(s) 5256-5261, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2015.03.075

High-throughput data analysis and data integration for vaccine trials

Author(s): January Weiner, Stefan H.E. Kaufmann, Jeroen Maertzdorf
Published in: Vaccine, Issue 33/40, 2015, Page(s) 5249-5255, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2015.04.096

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis

Author(s): Andrea Zelmer, Lisa Stockdale, Satria A. Prabowo, Felipe Cia, Natasha Spink, Matthew Gibb, Ayad Eddaoudi, Helen A. Fletcher
Published in: F1000Research, Issue 7, 2018, Page(s) 296, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.14239.1

First description of agonist and antagonist IP-10 in urine of patients with active TB

Author(s): Linda Petrone, Vincent Bondet, Valentina Vanini, Gilda Cuzzi, Fabrizio Palmieri, Ivana Palucci, Giovanni Delogu, Fabiola Ciccosanti, Gian Maria Fimia, Thomas Blauenfeldt, Morten Ruhwald, Darragh Duffy, Delia Goletti
Published in: International Journal of Infectious Diseases, Issue 78, 2019, Page(s) 15-21, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2018.09.001

Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions

Author(s): Thomas Blauenfeldt, Linda Petrone, Franca del Nonno, Andrea Baiocchini, Laura Falasca, Teresa Chiacchio, Vincent Bondet, Valentina Vanini, Fabrizio Palmieri, Gianni Galluccio, Armanda Casrouge, Jesper Eugen-Olsen, Matthew L. Albert, Delia Goletti, Darragh Duffy, Morten Ruhwald
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01456

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

Author(s): Helen A. Fletcher
Published in: mBio, Issue 7/4, 2016, ISSN 2150-7511
Publisher: MBio
DOI: 10.1128/mBio.01370-16

Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

Author(s): Cheleka A. M. Mpande, One B. Dintwe, Munyaradzi Musvosvi, Simbarashe Mabwe, Nicole Bilek, Mark Hatherill, Elisa Nemes, Thomas J. Scriba
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.00324

Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria

Author(s): Romain Veyron-Churlet, Vincent Dupres, Jean-Michel Saliou, Frank Lafont, Dominique Raze, Camille Locht
Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1673, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19061673

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Author(s): Line L. Holm, Milica Vukmanovic-Stejic, Thomas Blauenfeldt, Thomas Benfield, Peter Andersen, Arne N. Akbar, Morten Ruhwald
Published in: Journal of Visualized Experiments, Issue 138, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/57554

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Author(s): Louis S. Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P. M. Damen, Daria Bottai, Marcel A. Behr, Jeroen W. J. van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
Published in: PLOS Pathogens, Issue 14/6, 2018, Page(s) e1007139, ISSN 1553-7374
Publisher: PLoS Pathogens
DOI: 10.1371/journal.ppat.1007139

Biosafety Level 3 setup for multiphoton microscopy in vivo

Author(s): D. Barlerin, G. Bessière, J. Domingues, M. Schuette, C. Feuillet, A. Peixoto
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-00702-x

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction

Author(s): Frank Vrieling, Louis Wilson, Patrick C. N. Rensen, Gerhard Walzl, Tom H. M. Ottenhoff, Simone A. Joosten
Published in: PLOS Pathogens, Issue 15/4, 2019, Page(s) e1007724, ISSN 1553-7374
Publisher: PLoS Pathogens
DOI: 10.1371/journal.ppat.1007724

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

Author(s): Christophe J. Queval, Roland Brosch, Roxane Simeone
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.02284

The Conventional Nature of Non-MHC-Restricted T Cells

Author(s): Marco Lepore, Lucia Mori, Gennaro De Libero
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01365

New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

Author(s): Jesús Gonzalo-Asensio, Irene Pérez, Nacho Aguiló, Santiago Uranga, Ana Picó, Carlos Lampreave, Alberto Cebollada, Isabel Otal, Sofía Samper, Carlos Martín
Published in: PLOS Genetics, Issue 14/4, 2018, Page(s) e1007282, ISSN 1553-7404
Publisher: PLoS Pathogens
DOI: 10.1371/journal.pgen.1007282

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application

Author(s): Mariateresa Coppola, Susan J. F. van den Eeden, Naoko Robbins, Louis Wilson, Kees L. M. C. Franken, Linda B. Adams, Tom P. Gillis, Tom H. M. Ottenhoff, Annemieke Geluk
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontier in Immunulogy
DOI: 10.3389/fimmu.2018.00308

Mycobacterium tuberculosis Invasion of the Human Lung: First Contact

Author(s): Jeroen Maertzdorf, Mario Tönnies, Laura Lozza, Sandra Schommer-Leitner, Hans Mollenkopf, Torsten T. Bauer, Stefan H. E. Kaufmann
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01346

The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases

Author(s): Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.00155

Macrophage Autophagy and Bacterial Infections

Author(s): Aïcha Bah, Isabelle Vergne
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01483

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

Author(s): John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-05057-x

Data-driven model for the assessment of Mycobacterium tuberculosis transmission in evolving demographic structures

Author(s): Sergio Arregui, María José Iglesias, Sofía Samper, Dessislava Marinova, Carlos Martin, Joaquín Sanz, Yamir Moreno
Published in: Proceedings of the National Academy of Sciences, Issue 115/14, 2018, Page(s) E3238-E3245, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1720606115

Understanding immune protection against tuberculosis using RNA expression profiling

Author(s): Ulrich von Both, Myrsini Kaforou, Michael Levin, Sandra M. Newton
Published in: Vaccine, Issue 33/40, 2015, Page(s) 5289-5293, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2015.05.025

Next-Generation Vaccines Based on Bacille Calmette–Guérin

Author(s): Natalie E. Nieuwenhuizen, Stefan H. E. Kaufmann
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.00121

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

Author(s): Frank Vrieling, Katharina Ronacher, Léanie Kleynhans, Erik van den Akker, Gerhard Walzl, Tom H.M. Ottenhoff, Simone A. Joosten
Published in: EBioMedicine, Issue 32, 2018, Page(s) 192-200, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2018.05.011

A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis

Author(s): Stéphane Leung-Theung-Long, Charles-Antoine Coupet, Marie Gouanvic, Doris Schmitt, Aurélie Ray, Chantal Hoffmann, Huguette Schultz, Sandeep Tyagi, Heena Soni, Paul J. Converse, Lilibeth Arias, Patricia Kleinpeter, Benoît Sansas, Khisimuzi Mdluli, Cristina Vilaplana, Pere-Joan Cardona, Eric Nuermberger, Jean-Baptiste Marchand, Nathalie Silvestre, Geneviève Inchauspé
Published in: PLOS ONE, Issue 13/5, 2018, Page(s) e0196815, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0196815

Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection

Author(s): Teresa Chiacchio, Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Flavio De Maio, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
Published in: PLOS ONE, Issue 12/8, 2017, Page(s) e0183846, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0183846

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy

Author(s): Gang Pei, Hellen Buijze, Haipeng Liu, Pedro Moura-Alves, Christian Goosmann, Volker Brinkmann, Hiroshi Kawabe, Anca Dorhoi, Stefan H. E. Kaufmann
Published in: Autophagy, Issue 13/12, 2017, Page(s) 2041-2055, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2017.1376160

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

Author(s): Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01119

Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice

Author(s): Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Grant A Hill-Cawthorne, Carl G Feng, Warwick J Britton, James A Triccas
Published in: npj Vaccines, Issue 1/1, 2016, ISSN 2059-0105
Publisher: NPJ Vaccines
DOI: 10.1038/npjvaccines.2016.12

Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

Author(s): Leonar Arroyo, Diana Marín, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Luis F. Barrera
Published in: BMC Infectious Diseases, Issue 18/1, 2018, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-017-2929-0

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

Author(s): Simone A. Joosten, Krista E. van Meijgaarden, Franca del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H. Smits, Fabrizio Palmieri, Delia Goletti, Tom H. M. Ottenhoff
Published in: PLOS Pathogens, Issue 12/6, 2016, Page(s) e1005687, ISSN 1553-7374
Publisher: PLos Pathogens
DOI: 10.1371/journal.ppat.1005687

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Author(s): Fadel Sayes, Catherine Blanc, Louis S. Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I. Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi
Published in: Cell Reports, Issue 23/4, 2018, Page(s) 1072-1084, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.03.125

Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli

Author(s): Kerri M. Malone, Kévin Rue-Albrecht, David A. Magee, Kevin Conlon, Olga T. Schubert, Nicolas C. Nalpas, John A. Browne, Alicia Smyth, Eamonn Gormley, Ruedi Aebersold, David E. MacHugh, Stephen V. Gordon
Published in: Microbial Genomics, Issue 4/3, 2018, ISSN 2057-5858
Publisher: ETH Zurich
DOI: 10.1099/mgen.0.000163

The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis

Author(s): Nishtha Jhilmeet, David M. Lowe, Catherine Riou, Thomas J. Scriba, Anna Coussens, Rene Goliath, Robert J. Wilkinson, Katalin Andrea Wilkinson
Published in: PLOS ONE, Issue 13/12, 2018, Page(s) e0209516, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0209516

Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination

Author(s): Mardi C. Boer, Simone A. Joosten, Tom H. M. Ottenhoff
Published in: Frontiers in Immunology, Issue 6, 2015, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2015.00217

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases

Author(s): Bas C. Mourik, Erik Lubberts, Jurriaan E. M. de Steenwinkel, Tom H. M. Ottenhoff, Pieter J. M. Leenen
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00294

Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease

Author(s): Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
Published in: PLOS ONE, Issue 13/3, 2018, Page(s) e0192664, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0192664

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study

Author(s): Justin Shenje, Rachel P. Lai, Ian L. Ross, Bongani M. Mayosi, Robert J. Wilkinson, Mpiko Ntsekhe, Katalin A. Wilkinson
Published in: IJC Heart & Vasculature, Issue 18, 2018, Page(s) 104-108, ISSN 2352-9067
Publisher: Elsevier
DOI: 10.1016/j.ijcha.2017.10.002

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine

Author(s): Elena Stylianou, Rachel Harrington-Kandt, Julia Beglov, Naomi Bull, Nawamin Pinpathomrat, Gwendolyn M. Swarbrick, Deborah A. Lewinsohn, David M. Lewinsohn, Helen McShane
Published in: Infection and Immunity, Issue 86/7, 2018, Page(s) e00014-18, ISSN 0019-9567
Publisher: American Society for Microbiology
DOI: 10.1128/IAI.00014-18

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Author(s): Christophe J. Queval, Ok-Ryul Song, Jean-Philippe Carralot, Jean-Michel Saliou, Antonino Bongiovanni, Gaspard Deloison, Nathalie Deboosère, Samuel Jouny, Raffaella Iantomasi, Vincent Delorme, Anne-Sophie Debrie, Sei-Jin Park, Joana Costa Gouveia, Stanislas Tomavo, Roland Brosch, Akihiko Yoshimura, Edouard Yeramian, Priscille Brodin
Published in: Cell Reports, Issue 20/13, 2017, Page(s) 3188-3198, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.08.101

Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection

Author(s): January Weiner, Teresa Domaszewska, Simon Donkor, Stefan H E Kaufmann, Philip C Hill, Jayne S Sutherland
Published in: Clinical Infectious Diseases, 2019, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciz785

Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing

Author(s): David Pejoski, Marie Ballester, Floriane Auderset, Maria Vono, Dennis Christensen, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.01650

Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate

Author(s): Caridad Díaz, José Pérez del Palacio, Pedro Luis Valero-Guillén, Patricia Mena García, Irene Pérez, Francisca Vicente, Carlos Martín, Olga Genilloud, Antonio Sánchez Pozo, Jesús Gonzalo-Asensio
Published in: ACS Infectious Diseases, Issue 5/8, 2019, Page(s) 1317-1326, ISSN 2373-8227
Publisher: ACS infectious disease
DOI: 10.1021/acsinfecdis.9b00008

Tuberculosis antigen-specific T cell responses during the first 6 months of antiretroviral treatment

Author(s): Catherine Riou, Nishtha Jhilmeet, Molebogeng X Rangaka, Robert J Wilkinson, Katalin A Wilkinson
Published in: The Journal of Infectious Diseases, 2019, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiz417

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

Author(s): Karin Dijkman, Claudia C. Sombroek, Richard A. W. Vervenne, Sam O. Hofman, Charelle Boot, Edmond J. Remarque, Clemens H. M. Kocken, Tom H. M. Ottenhoff, Ivanela Kondova, Mohammed A. Khayum, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Published in: Nature Medicine, Issue 25/2, 2019, Page(s) 255-262, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0319-9

Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

Author(s): Frida Arrey, Delia Löwe, Stefanie Kuhlmann, Peggy Kaiser, Pedro Moura-Alves, Gopinath Krishnamoorthy, Laura Lozza, Jeroen Maertzdorf, Tatsiana Skrahina, Alena Skrahina, Martin Gengenbacher, Geraldine Nouailles, Stefan H. E. Kaufmann
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.00089

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

Author(s): Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.02832

An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

Author(s): Diana Mendes Freire, Claude Gutierrez, Acely Garza-Garcia, Anna D. Grabowska, Ambre J. Sala, Kanchiyaphat Ariyachaokun, Terezie Panikova, Katherine S.H. Beckham, André Colom, Vivian Pogenberg, Michele Cianci, Anne Tuukkanen, Yves-Marie Boudehen, Antonio Peixoto, Laure Botella, Dmitri I. Svergun, Dirk Schnappinger, Thomas R. Schneider, Pierre Genevaux, Luiz Pedro Sorio de Carvalho, Matthias Wilman
Published in: Molecular Cell, Issue 73/6, 2019, Page(s) 1282-1291.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.01.028

Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis

Author(s): Rosalie Lubbers, Jayne S. Sutherland, Delia Goletti, Roelof A. de Paus, Coline H. M. van Moorsel, Marcel Veltkamp, Stefan M. T. Vestjens, Willem J. W. Bos, Linda Petrone, Franca Del Nonno, Ingeborg M. Bajema, Karin Dijkman, Frank A. W. Verreck, Gerhard Walzl, Kyra A. Gelderman, Geert H. Groeneveld, Annemieke Geluk, Tom H. M. Ottenhoff, Simone A. Joosten, Leendert A. Trouw
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.02427

HBHA-Induced Polycytotoxic CD4 + T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans

Author(s): Laetitia Aerts, Elodie Selis, Véronique Corbière, Kaat Smits, Anne Van Praet, Nicolas Dauby, Emmanuelle Petit, Mahavir Singh, Camille Locht, Violette Dirix, Françoise Mascart
Published in: The Journal of Immunology, Issue 202/2, 2019, Page(s) 421-427, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1800840

Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01

Author(s): Alexander Wilkinson, Eric Lattmann, Carla B. Roces, Gabriel K. Pedersen, Dennis Christensen, Yvonne Perrie
Published in: Journal of Controlled Release, Issue 291, 2018, Page(s) 1-10, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.10.002

Plasma Biomarkers to Detect Prevalent or Predict Progressive Tuberculosis Associated With Human Immunodeficiency Virus–1

Author(s): Maia Lesosky, Molebogeng X Rangaka, Cara Pienaar, Anna K Coussens, Rene Goliath, Shaheed Mathee, Judith Mwansa-Kambafwile, Gary Maartens, Robert J Wilkinson, Katalin Andrea Wilkinson
Published in: Clinical Infectious Diseases, 2018, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciy823

Proportions of interferon-γ-producing ascites lymphocytes in response to mycobacterial antigens: A help for early diagnosis of peritoneal tuberculosis in a low TB incidence country

Author(s): Sophie Henrard, Véronique Corbière, Liliane Schandené, Martine Ducarme, Anne Van Praet, Emmanuelle Petit, Mahavir Singh, Camille Locht, Violette Dirix, Françoise Mascart
Published in: PLOS ONE, Issue 14/4, 2019, Page(s) e0214333, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0214333

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis

Author(s): Mariateresa Coppola, Susan J. F. van den Eeden, Louis Wilson, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Annemieke Geluk
Published in: Clinical and Vaccine Immunology, Issue 22/9, 2015, Page(s) 1060-1069, ISSN 1556-6811
Publisher: American Society for Microbiology
DOI: 10.1128/CVI.00271-15

Vaccination in early life: standing up to the challenges

Author(s): Elodie Mohr, Claire-Anne Siegrist
Published in: Current Opinion in Immunology, Issue 41, 2016, Page(s) 1-8, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2016.04.004

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo

Author(s): Santiago Uranga, Dessislava Marinova, Carlos Martin, Julián Pardo, Nacho Aguilo
Published in: PLOS ONE, Issue 11/4, 2016, Page(s) e0153028, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0153028

The BCG Strain Pool: Diversity Matters

Author(s): Daria Bottai, Roland Brosch
Published in: Molecular Therapy, Issue 24/2, 2016, Page(s) 201-203, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1038/mt.2016.18

BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs

Author(s): E. Kaufmann, C. Spohr, S. Battenfeld, D. De Paepe, T. Holzhauser, E. Balks, S. Homolka, N. Reiling, M. Gilleron, M. Bastian
Published in: The Journal of Immunology, Issue 196/6, 2016, Page(s) 2723-2732, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1502307

Molecular Determinants in Phagocyte-Bacteria Interactions

Author(s): Stefan H.E. Kaufmann, Anca Dorhoi
Published in: Immunity, Issue 44/3, 2016, Page(s) 476-491, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2016.02.014

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis

Author(s): Anca Dorhoi, Stefan H.E. Kaufmann
Published in: Seminars in Immunopathology, Issue 38/2, 2016, Page(s) 153-166, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-015-0531-3

Post-exposure vaccination with the vaccine candidate Bacillus Calmette–Guérin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis

Author(s): Martin Gengenbacher, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Stefan H.E. Kaufmann
Published in: Microbes and Infection, Issue 18/5, 2016, Page(s) 364-368, ISSN 1286-4579
Publisher: Elsevier BV
DOI: 10.1016/j.micinf.2016.03.005

Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance

Author(s): Nadia Caccamo, Francesco Dieli
Published in: European Journal of Immunology, Issue 46/2, 2016, Page(s) 303-306, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546225

Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems

Author(s): Emilie Dumas, Eva Christina Boritsch, Mathias Vandenbogaert, Ricardo C. Rodríguez de la Vega, Jean-Michel Thiberge, Valerie Caro, Jean-Louis Gaillard, Beate Heym, Fabienne Girard-Misguich, Roland Brosch, Guillaume Sapriel
Published in: Genome Biology and Evolution, Issue 8/2, 2016, Page(s) 387-402, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evw001

On the impact of masking and blocking hypotheses for measuring the efficacy of new tuberculosis vaccines

Author(s): Sergio Arregui, Joaquín Sanz, Dessislava Marinova, Carlos Martín, Yamir Moreno
Published in: PeerJ, Issue 4, 2016, Page(s) e1513, ISSN 2167-8359
Publisher: PeerJ
DOI: 10.7717/peerj.1513

An open-source computational and data resource to analyze digital maps of immunopeptidomes

Author(s): Etienne Caron, Lucia Espona, Daniel J Kowalewski, Heiko Schuster, Nicola Ternette, Adán Alpízar, Ralf B Schittenhelm, Sri H Ramarathinam, Cecilia S Lindestam Arlehamn, Ching Chiek Koh, Ludovic C Gillet, Armin Rabsteyn, Pedro Navarro, Sangtae Kim, Henry Lam, Theo Sturm, Miguel Marcilla, Alessandro Sette, David S Campbell, Eric W Deutsch, Robert L Moritz, Anthony W Purcell, Hans-Georg Rammensee, S
Published in: eLife, Issue 4, 2015, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.07661

MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

Author(s): Nacho Aguilo, Santiago Uranga, Dessislava Marinova, Marta Monzon, Juan Badiola, Carlos Martin
Published in: Tuberculosis, Issue 96, 2016, Page(s) 71-74, ISSN 1472-9792
Publisher: Churchill Livingstone
DOI: 10.1016/j.tube.2015.10.010

Manufacturing Methods for Liposome Adjuvants

Author(s): Yvonne Perrie, Elisabeth Kastner, Swapnil Khadke, Carla B. Roces, Peter Stone
Published in: 2017, Page(s) 127-144
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6445-1_9

A data-driven model for the assessment of age-dependent patterns of Tuberculosis burden and impact evaluation of novel vaccines.

Author(s): Arregui, Sergio; Marinova, Dessislava; Iglesias, Maria; Samper, Sofia; Martin, Carlos; Sanz, Joaquin; Moreno, Yamir
Published in: BioRxiv, Issue November 2017, 2017
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/112409

Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

Author(s): Esther Broset, Carlos Martín, Jesús Gonzalo-Asensio
Published in: mBio, Issue 6/5, 2015, Page(s) e01289-15, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mBio.01289-15

Immunological Signatures Identifying Different Stages of Latent Mycobacterium tuberculosis Infection and Discriminating Latent from Active Tuberculosis in Humans

Author(s): Kaatje Smits Veronique
Published in: Journal of Clinical & Cellular Immunology, Issue 06/04, 2015, ISSN 2155-9899
Publisher: Journal of Clinical & Cellular Immunology
DOI: 10.4172/2155-9899.1000341

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers

Author(s): Maria M. Esterhuyse, January Weiner, Etienne Caron, Andre G. Loxton, Marco Iannaccone, Chandre Wagman, Philippe Saikali, Kim Stanley, Witold E. Wolski, Hans-Joachim Mollenkopf, Matthias Schick, Ruedi Aebersold, Heinz Linhart, Gerhard Walzl, Stefan H. E. Kaufmann
Published in: mBio, Issue 6/5, 2015, Page(s) e01187-15, ISSN 2150-7511
Publisher: American publisher for Microbiology
DOI: 10.1128/mBio.01187-15

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