TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

Rezultaty

Transcriptomic, immunomic and metabolic correlates of TB infection

Transcriptomic, immunomic and metabolic correlates of TB infection, vaccine induced immunity and protection (M48)

Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART

Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART; and identify potential biomarkers of reduced susceptibility to TB, incl. diagnostic and prognostic protein biomarkers in plasma (M30)

Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles

Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles (cytokine, chemokine and cytotoxic molecule expression, memory, activation and homing markers, chemokine receptors, etc) in M.tbuninfected, M.tb-infected (latent), TB diseased and in vaccinated persons (M48)

List of the autophagic and miRNA markers analyzed and correlatio

List of the autophagic and miRNA markers analyzed and correlation with TB clinical outcome (M48)

Global TB vaccine meeting

Organization of global vaccine meeting (M10)

Bioinformatic signature validation and data integration

Bioinformatic signature validation and data integration. Pathway analysis of long term non-progressor Signatures (M48)

Validate biomarkers that predict the development of active TB in HIV infected persons

Validate biomarkers that predict the development of active TB in HIV infected persons will be validated in a second set of plasma (M42)

Targeted Luminex analysis to define M.tb-specific soluble host bio-signatures

Targeted Luminex analysis to define M.tb-specific soluble host bio-signatures from subjects with different TB/HIV infection phenotypes that can be used for identification of ‘at-risk’ subjects. Samples from minimally 3- sites (Gambia, S. Africa, Malawi) (M36)

Detection of cytotoxic and bactericidal molecules intracellularly a

Detection of cytotoxic and bactericidal molecules intracellularly and in stimulated plasma by ELISA/Luminex in patients before and during therapy (M48)

Discovery Luminex analysis define key antigen-analyte and dcRT-MLPA RNA analysis combinations

Discovery Luminex analysis using Gambian and S. African subjects to define key antigen-analyte and dcRT-MLPA RNA analysis combinations (M18)

head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA

Data on head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA for the measurement of correlates of protection against TB (M48)

Data from measurements of selected immune mediators

Data from measurements of selected immune mediators (including epigenetic modifiers of immune responses and associated infant cellular responses) in UK and Ugandan infants as well as the effect of BCG vaccination on these mediators (M48)

Identification of a repertoire of surface molecules on NK cells and DC subsets and related cytokines associated with latent versus active TB

Identification of a repertoire of surface molecules on NK cells and DC subsets and of related cytokines associated with latency versus active TB (M36)

Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants

Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants (M.tb antigen specific marker production in whole blood, RNA sequencing, metabolomics and miRNA expression) (M48)

3 Annual project meetings

Annual project meetings (TBVI; M14, M26, M38)

Identification of transcriptomic biomarkers predictive of an efficient immune response

Identification of transcriptomic biomarkers predictive of an efficient immune response to MTBVAC vs. BCG (M24)

Identification of potential immune correlates from the human mycobacterial challenge model

report on Identification of potential immune correlates from the human mycobacterial challenge model

Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells

Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells, macrophage subsets and plasma chemokines and cytokines in patients with M.tb or M.tb/HIV co-infection, before, during and after treatment (M48)

Combination of HBHA and adjuvant has been selected

publication on HBHA adjuvant selection

A first version TB Biomarker data base

A first version TB Biomarker data base for tailor made selection of assays for specific trials and studies (M48)

Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infection”

(M48) Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infection”

Collection of samples from S. Korean LTBI cohort

Collection of samples (plasma/serum, QFT supernatants/blood clots, WBA supernatants, RNA and mRNA PAXgene tubes) from S. Korean LTBI cohort. (M24) and Testing of biomarkers using standardized assay protocols on samples from S. Korean LTBI cohort (M42)

RNA expression correlate of functional

RNA expression correlate of functional (whole blood killing) immune responses to M.tb infection, BCG or novel TB vaccines (M36)

Correlates of risk for, and protection from, active TB

Correlates of risk for, and protection from, active TB based on host markers produced in response to M.tb infection stage specific proteins (M40)

correlation of hematopoietic progenitor cell populations

Report on correlation of hematopoietic progenitor cell populations with vaccine immunogenicity and risk of TB disease (M24)

Transcriptome analyses of approx. 700 microarrays of Belarus cohort

Transcriptome analyses of approx. 700 microarrays of Belarus cohort completed; dData analysis and validation with qPCR completed. First cell specific biosignatures identified in Belarus

Systems biology analysis to define biosignatures of protection to latent TB

Systems biology analysis to define biosignatures of protection to latent TB using TB exposed but persistently TST negative subjects (combined metabolomics, RNA-seq) (M36)

Cohort data base and related specimen bank collection

Cohort data base and related specimen bank collection. Four hundred HIV-infected and uninfected subjects either with LTBI, active TB followed during treatment and controls no M.tb-infected will be enrolled (M30)

Fully optimized protocols for isolation and ICS characterization of Suction Blister

Fully optimized protocols for isolation and ICS characterization of Suction Blister Mononuclear Cells and SBMC based MGIA (M2412)

Identification of a signature that distinguishes long term non- progressors from recently infected individuals

Identification of a signature that distinguishes long term non- progressors from recently infected individuals, and validation in second cohort(M48)

Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and human

Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and humans immunized with live- and lipid-based vaccines with the outcome of vaccination (M48)

Establish Portfolio management committee

Establish PMC and processes and implementation of portfolio management approach (M8)

Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial

Report with data of Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial in samples from subsequent clinical trials with optimised immunisation regimes

Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bank

Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bank containing mRNA and supernatants from bronchoalveolar lavage cells and blood from the German study cohort “TB-or-not-TB”. (M36)

Project website established

Publikacje

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung

Autorzy: J S Woodworth, S B Cohen, A O Moguche, C R Plumlee, E M Agger, K B Urdahl, P Andersen
Opublikowane w: Mucosal Immunology, Numer 10/2, 2016, Strona(/y) 555-564, ISSN 1933-0219
Wydawca: Nature Publishing Group
DOI: 10.1038/mi.2016.70

What Have We Learnt about BCG Vaccination in the Last 20 Years?

Autorzy: Hazel M. Dockrell, Steven G. Smith
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.01134

Rapid Quantification and Validation of Lipid Concentrations within Liposomes

Autorzy: Carla Roces, Elisabeth Kastner, Peter Stone, Deborah Lowry, Yvonne Perrie
Opublikowane w: Pharmaceutics, Numer 8/4, 2016, Strona(/y) 29, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics8030029

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

Autorzy: Steven G. Smith, Kaatje Smits, Simone A. Joosten, Krista E. van Meijgaarden, Iman Satti, Helen A. Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M. Dockrell, Tom H. M. Ottenhoff
Opublikowane w: PLOS ONE, Numer 10/9, 2015, Strona(/y) e0138042, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0138042

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Autorzy: Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I. Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J. Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
Opublikowane w: PLOS Pathogens, Numer 12/7, 2016, Strona(/y) e1005770, ISSN 1553-7374
Wydawca: PLos Pathogans
DOI: 10.1371/journal.ppat.1005770

The SysteMHC Atlas project

Autorzy: Wenguang Shao, Patrick G A Pedrioli, Witold Wolski, Cristian Scurtescu, Emanuel Schmid, Juan A Vizcaíno, Mathieu Courcelles, Heiko Schuster, Daniel Kowalewski, Fabio Marino, Cecilia S L Arlehamn, Kerrie Vaughan, Bjoern Peters, Alessandro Sette, Tom H M Ottenhoff, Krista E Meijgaarden, Natalie Nieuwenhuizen, Stefan H E Kaufmann, Ralph Schlapbach, John C Castle, Alexey I Nesvizhskii, Morten Niel
Opublikowane w: Nucleic Acids Research, Numer 46/D1, 2017, Strona(/y) D1237-D1247, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkx664

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis

Autorzy: Hermann Giresse Tima, Juma''a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
Opublikowane w: Journal of Innate Immunity, Numer 9/2, 2017, Strona(/y) 162-180, ISSN 1662-811X
Wydawca: Karger AG
DOI: 10.1159/000450955

A method permissive to fixation and permeabilization for the multiparametric analysis of apoptotic and necrotic cell phenotype by flow cytometry

Autorzy: Sabrina Mariotti, Manuela Pardini, Raffaela Teloni, Maria Cristina Gagliardi, Maurizio Fraziano, Roberto Nisini
Opublikowane w: Cytometry Part A, Numer 91/11, 2017, Strona(/y) 1115-1124, ISSN 1552-4922
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23268

Breaking Transmission with Vaccines: The Case of Tuberculosis

Autorzy: Jesus Gonzalo-Asensio, Nacho Aguilo, Dessislava Marinova, Carlos Martin
Opublikowane w: Microbiology Spectrum, Numer 5/4, 2017, ISSN 2165-0497
Wydawca: American Society for Microbiology
DOI: 10.1128/microbiolspec.MTBP-0001-2016

Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

Autorzy: Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-02116-1

Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

Autorzy: Ans De Beuckelaer, Johan Grooten, Stefaan De Koker
Opublikowane w: Trends in Molecular Medicine, Numer 23/3, 2017, Strona(/y) 216-226, ISSN 1471-4914
Wydawca: Elsevier BV
DOI: 10.1016/j.molmed.2017.01.006

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

Autorzy: Andrea Zelmer, Rachel Tanner, Elena Stylianou, Timon Damelang, Sheldon Morris, Angelo Izzo, Ann Williams, Sally Sharpe, Ilaria Pepponi, Barry Walker, David A. Hokey, Helen McShane, Michael Brennan, Helen Fletcher
Opublikowane w: BMC Infectious Diseases, Numer 16/1, 2016, ISSN 1471-2334
Wydawca: BioMed Central
DOI: 10.1186/s12879-016-1751-4

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

Autorzy: Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Opublikowane w: PLOS ONE, Numer 12/2, 2017, Strona(/y) e0171358, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0171358

Application of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System

Autorzy: Raj Badhan, Swapnil Khadke, Yvonne Perrie
Opublikowane w: Pharmaceutics, Numer 9/4, 2017, Strona(/y) 57, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics9040057

The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010–2014

Autorzy: Michael J. Brennan, Rachel Tanner, Sheldon Morris, Thomas J. Scriba, Jacqueline M. Achkar, Andrea Zelmer, David A. Hokey, Angelo Izzo, Sally Sharpe, Ann Williams, Adam Penn-Nicholson, Mzwandile Erasmus, Elena Stylianou, Daniel F. Hoft, Helen McShane, Helen A. Fletcher
Opublikowane w: Clinical and Vaccine Immunology, Numer 24/9, 2017, Strona(/y) e00142-17, ISSN 1556-6811
Wydawca: American Society for Microbiology
DOI: 10.1128/CVI.00142-17

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

Autorzy: Jesus Gonzalo-Asensio, Dessislava Marinova, Carlos Martin, Nacho Aguilo
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.01803

T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties

Autorzy: Thomas Lindenstrøm, Albanus Moguche, Mie Damborg, Else Marie Agger, Kevin Urdahl, Peter Andersen
Opublikowane w: EBioMedicine, Numer 27, 2018, Strona(/y) 27-39, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2017.12.004

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

Autorzy: Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin
Opublikowane w: Nature Communications, Numer 8, 2017, Strona(/y) 16085, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms16085

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

Autorzy: Sameer Joshi, Maryam T. Hussain, Carla B. Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J. Kirby, Yvonne Perrie
Opublikowane w: International Journal of Pharmaceutics, Numer 514/1, 2016, Strona(/y) 160-168, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.09.027

Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study

Autorzy: Helen A. Fletcher, Ali Filali-Mouhim, Elisa Nemes, Anthony Hawkridge, Alana Keyser, Samuel Njikan, Mark Hatherill, Thomas J. Scriba, Brian Abel, Benjamin M. Kagina, Ashley Veldsman, Nancy Marín Agudelo, Gilla Kaplan, Gregory D. Hussey, Rafick-Pierre Sekaly, Willem A. Hanekom
Opublikowane w: BMC Medicine, Numer 14/1, 2016, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-016-0617-3

Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance

Autorzy: Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 45120, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep45120

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

Autorzy: Steven G. Smith, Andrea Zelmer, Rose Blitz, Helen A. Fletcher, Hazel M. Dockrell
Opublikowane w: Vaccine, Numer 34/44, 2016, Strona(/y) 5298-5305, ISSN 0264-410X
Wydawca: Elsevier BV
DOI: 10.1016/j.vaccine.2016.09.002

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

Autorzy: Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Brij, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.01203

Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation

Autorzy: Steven G. Smith, Johanneke Kleinnijenhuis, Mihai G. Netea, Hazel M. Dockrell
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.00644

Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis

Autorzy: Alexandra Dreesman, Véronique Corbière, Violette Dirix, Kaat Smits, Sara Debulpaep, Iris De Schutter, Myriam Libin, Mahavir Singh, Anne Malfroot, Camille Locht, Françoise Mascart
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.01059

T-cell activation is an immune correlate of risk in BCG vaccinated infants

Autorzy: Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson, Elisa Nemes, Mark Hatheril,
Opublikowane w: Nature Communications, Numer 7, 2016, Strona(/y) 11290, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms11290

Mycobacterium tuberculosis -associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

Autorzy: Muriel Smet, Charlotte Pollard, Ans De Beuckelaer, Lien Van Hoecke, Seppe Vander Beken, Stefaan De Koker, Juma'a R. Al Dulayymi, Kris Huygen, Jan Verschoor, Mark S. Baird, Johan Grooten
Opublikowane w: European Journal of Immunology, Numer 46/9, 2016, Strona(/y) 2149-2154, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646357

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Autorzy: Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy, Stefaan De Koker
Opublikowane w: Advanced Healthcare Materials, Numer 6/13, 2017, Strona(/y) 1601412, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201601412

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries

Autorzy: Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin
Opublikowane w: Expert Review of Vaccines, Numer 16/6, 2017, Strona(/y) 565-576, ISSN 1476-0584
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14760584.2017.1324303

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells

Autorzy: Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Opublikowane w: European Journal of Immunology, Numer 48/2, 2018, Strona(/y) 293-305, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747184

Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity

Autorzy: Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E. Kirwan, Hannah Steinberg, Robert H. Gilman, Emanuel F. Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
Opublikowane w: Science Translational Medicine, Numer 9/420, 2017, Strona(/y) eaal2807, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aal2807

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Autorzy: Rachel Tanner, Matthew K. O’Shea, Andrew D. White, Julius Müller, Rachel Harrington-Kandt, Magali Matsumiya, Mike J. Dennis, Eneida A. Parizotto, Stephanie Harris, Elena Stylianou, Vivek Naranbhai, Paulo Bettencourt, Hal Drakesmith, Sally Sharpe, Helen A. Fletcher, Helen McShane
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 43478, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep43478

A Case for a Human Immuno-Peptidome Project Consortium

Autorzy: Etienne Caron, Ruedi Aebersold, Amir Banaei-Esfahani, Chloe Chong, Michal Bassani-Sternberg
Opublikowane w: Immunity, Numer 47/2, 2017, Strona(/y) 203-208, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2017.07.010

Novel approaches to tuberculosis vaccine development

Autorzy: Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn
Opublikowane w: International Journal of Infectious Diseases, Numer 56, 2017, Strona(/y) 263-267, ISSN 1201-9712
Wydawca: Elsevier BV
DOI: 10.1016/j.ijid.2016.10.018

Functionally diverse human T cells recognize non-microbial antigens presented by MR1

Autorzy: Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero
Opublikowane w: eLife, Numer 6, 2017, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/eLife.24476

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

Autorzy: Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, Andre Kubler, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Bruno B. Andrade
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.00542

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Autorzy: Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Opublikowane w: Cell Reports, Numer 18/11, 2017, Strona(/y) 2752-2765, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2017.02.057

Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals

Autorzy: Catherine Riou, Natacha Berkowitz, Rene Goliath, Wendy A. Burgers, Robert J. Wilkinson
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.00968

The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing

Autorzy: Natalie E. Nieuwenhuizen, Prasad S. Kulkarni, Umesh Shaligram, Mark F. Cotton, Cyrill A. Rentsch, Bernd Eisele, Leander Grode, Stefan H. E. Kaufmann
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2017.01147

Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection

Autorzy: Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Warwick J. Britton, Nikolai Petrovsky, James A. Triccas
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-09119-y

Novel vaccination approaches to prevent tuberculosis in children

Autorzy: James A. Triccas, Claudio Counoupas
Opublikowane w: Pneumonia, Numer 8/1, 2016, ISSN 2200-6133
Wydawca: Biomed Central
DOI: 10.1186/s41479-016-0020-z

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

Autorzy: Ekta Lachmandas, Macarena Beigier-Bompadre, Shih-Chin Cheng, Vinod Kumar, Arjan van Laarhoven, Xinhui Wang, Anne Ammerdorffer, Lily Boutens, Dirk de Jong, Thirumala-Devi Kanneganti, Mark S. Gresnigt, Tom H.M. Ottenhoff, Leo A.B. Joosten, Rinke Stienstra, Cisca Wijmenga, Stefan H.E. Kaufmann, Reinout van Crevel, Mihai G. Netea
Opublikowane w: European Journal of Immunology, Numer 46/11, 2016, Strona(/y) 2574-2586, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546259

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers

Autorzy: January Weiner, Stefan H.E. Kaufmann
Opublikowane w: International Journal of Infectious Diseases, Numer 56, 2017, Strona(/y) 258-262, ISSN 1201-9712
Wydawca: Elsevier BV
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From Immunologically Archaic to Neoteric Glycovaccines

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