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Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes

Project information

Grant agreement ID: 643774

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2019

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 3 614 083,75

  • EU contribution

    € 3 614 083,75

Coordinated by:

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

Objective

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden.
We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated.
Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Address

South Kensington Campus Exhibition Road
Sw7 2az London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 386 972,50

Participants (11)

DEVKI DEVI FOUNDATION SOCIETY

India

EU Contribution

€ 247 050

UNIVERSITY OF COLOMBO

Sri Lanka

EU Contribution

€ 155 550

UNIVERSITY OF KELANIYA

Sri Lanka

EU Contribution

€ 121 237,50

UNIVERSITY OF SURREY

United Kingdom

EU Contribution

€ 244 233,75

EALING HOSPITAL NHS TRUST

United Kingdom

LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST

United Kingdom

EU Contribution

€ 749 537,50

INSTITUTE FOR HEALTH POLICY

Sri Lanka

EU Contribution

€ 105 750

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 146 250

OULUN YLIOPISTO

Finland

EU Contribution

€ 166 990

PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE

Pakistan

EU Contribution

€ 113 612,50

SERVICES INSTITUTE OF MEDICAL SCIENCES

Pakistan

EU Contribution

€ 176 900

Project information

Grant agreement ID: 643774

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2019

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 3 614 083,75

  • EU contribution

    € 3 614 083,75

Coordinated by:

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom