Obiettivo The human microbiome plays essential roles in modulating human health and disease. Based on preliminary data as well as previously published work, I hypothesise that 1) the oral cavity acts as a reservoir of microbes which continuously seed the gut and that 2) specific aberrations of the microbiota along the gastrointestinal tract (GIT) are linked to the development of colorectal cancer (CRC) and oral cancer (OC). My aim is to test these hypotheses through an integratation of metagenomic and metatranscriptomic data generated from microbial consortia in the colons/recta as well as oral cavities of patients with CRC or OC, and compare these to healthy individuals. Successful completion of the project objectives would address the questions: which microbial strains survive passage from the oral cavity in to the gut? Does the mouth act as a reservoir for strains driving CRC development? And can a panel of multi-factorial biomarkers outperform current CRC and OC diagnostic standards? Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmicrobiology Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore EUROPEAN MOLECULAR BIOLOGY LABORATORY Contribution nette de l'UE € 171 460,80 Indirizzo Meyerhofstrasse 1 69117 Heidelberg Germania Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 171 460,80
