Bioinspired Nanostructures by Self-assembly of Amphiphilic Non-peptide Helical Foldamers in Aqueous Environment

Projektinformationen

FOLDASYNBIO

ID Finanzhilfevereinbarung: 661247

DOI 10.3030/661247

Das Projekt endete am 9 Oktober 2018

EK-Unterschriftsdatum 23 März 2015

Startdatum 1 September 2015

Enddatum 31 Oktober 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 185 076,00

EU-Beitrag € 185 076,00

Koordiniert durch

UNIVERSITE DE BORDEAUX
France

Ziel

The design and precise construction of biomimetic self-assembling systems in aqueous solution is a challenging yet potentially highly rewarding endeavor, contributing to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of biological processes. A high level of sophistication with control over morphologies and functions has been achieved by engineering self-assembling peptide-based building units. Although peptides possess a number of specific advantages including synthetic availability, modularity, one difficulty resides in precisely controlling the rules relating primary sequence and secondary structure. Alternatively, opportunities exist to develop bottom-up approaches using non-natural oligomers also referred to as foldamers, with predictable and well-defined folding patterns. Advances in foldamer chemistry bode well for their use as building units for the precise construction of nanometer scale assemblies and for possible applications. This project will move a step forward towards the realization of this mission, by developing protein-like quaternary arrangements under sequence based control using amphiphilic helical foldamers in aqueous conditions. The applicant has been trained in the synthesis of folded oligoamides and more importantly has acquired a high level of expertise in the design and structural characterization of peptide-based assemblies. He will join and bring his expertise to a host laboratory in France that has pioneered the development of urea-based helical foldamers. Secondment in one established European group with prominent expertise in X-ray crystallography techniques and biological structure determination will provide the appropriate combination of knowledge required for this multidisciplinary study. This approach will be a milestone in the design of foldamer-based quaternary architectures and may lead to new functional nanostructures.

Wissenschaftliches Gebiet

• natural sciences › earth and related environmental sciences › geology › mineralogy › crystallography
• natural sciences › mathematics › pure mathematics › topology
• natural sciences › chemical sciences › organic chemistry › hydrocarbons
• natural sciences › chemical sciences › catalysis
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry

Schlüsselbegriffe

• Foldamers
• Nanostructures
• Helical bundles
• peptidomimetics
• self-assembly

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Koordinator

UNIVERSITE DE BORDEAUX

• Netto-EU-Beitrag: € 185 076,00
• Adresse: PLACE PEY BERLAND 35 ; 33000 Bordeaux ; Frankreich
• Region: Nouvelle-Aquitaine › Aquitaine › Gironde
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 185 076,00