Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

H2020

CHROMAVISION

Project ID: 665233
Financiado con arreglo a

Super-resolution visualisation and manipulation of metaphase chromosomes

Desde 2015-06-01 hasta 2019-05-31, proyecto en curso | CHROMAVISION Sitio web

Detalles del proyecto

Coste total:

EUR 3 567 025

Aportación de la UE:

EUR 3 567 025

Coordinado en:

Netherlands

Convocatoria de propuestas:

H2020-FETOPEN-2014-2015-RIASee other projects for this call

Régimen de financiación:

RIA - Research and Innovation action

Objetivo

Deliverables

  • Ethics documentation and Policies

    The core of the research in the later phases of the project will be conducted on biobank materials and cell lines. We will submit the ethics approval and required documents for working with this material within this milestone. The consortium will decide before month 6 if TRACERX clinical trail samples are used or not. If they are used we will gather all the required documentation such as the informed consent and information sheets. Moreover, we will explicitly confirm to REA that appropriate consent has been given by the participants of TRACERX to allow their samples and data to be used in the present research. The confirmation and the required materials in this case will be submitted before month 24. Next, if TRACERX material will be used we will have it anonymized so there will not be personal sensitive data. The same applies for a policy for the handling of any incidental findings that might arise when studying samples from participants. By anonymizing the data incidental findings will not be tracable to a person.

  • Detailed communication and dissemination plan

    Detailed communication and dissemination plan and annual updates. CHROMAVISION will developed a stakeholder engagement analysis (see also table in section 2.2. of the proposal). This concept plan provides the starting point for the dissemination and exploitation strategy. Understanding stakeholder motivations will enable the consortium to effectively engage, communicate with and promote future dialogue between different stakeholders and will help with more effective and targeted communication strategies for the different groups. All results of CHROMAVISION selected for publication will preferentially be made available through Open Access (OA) publication for broad dissemination. Either Green or Gold OA publishing models will be used. Annual updates take place at month 12,24,36,48

  • Bead-handles

    Bead-handles that can be easily connected to chromosome ends or centromers This task aims to develop a protocol that allows the attachment of optically trapped microspheres to a metaphase chromosome. First, the VU will explore the use of microspheres coated with antibodies. To this end we will use antibodies derived by UCPH against telomere-binding proteins or antibodies against centromere factors. A completely different approach we will pursue involve PNA or RNA linkers. These linkers hybridise more strongly with a complementary DNA strand than DNA itself. Another approach involves aptamers, nucleic acids that specifically bind to ligands. The expectation is that within 6 months chromosomes can be handled by specific attachment of optically trapped microspheres to chromosomes.

  • Collaborative and public website

    Public website Set up an website to provide information to the wide public

  • Dissemination material & updates

    Dissemination material & updates By M9 we have the infrastructure ready for: • Website: the CHROMAVISION website serves to feed all relevant stakeholders, including the general public, with information on project progress. The PIs will be asked to post regular new items about their work. The PIs will also introduce the WPs in a two-minute introduction video that is posted online. The website will integrate social media. • Animations: CHROMAVISION is a complex project. In WP4 an animation video will be developed that is comprehensible for all relevant stakeholders. The animation video will be used in external presentations. • Newsletter: All stakeholders will be informed with a quarterly newsletter (open for subscription) in which the project progress and relevant updates from outside the consortium are presented to all stakeholders. • Social-media platforms will be used to create a general awareness of CHROMAVISION.

Publications

Coordinador

STICHTING VU
Netherlands

Aportación de la UE: EUR 1 054 003,75


DE BOELELAAN 1105
1081 HV AMSTERDAM
Netherlands
Activity type: Higher or Secondary Education Establishments

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Participantes

DANMARKS TEKNISKE UNIVERSITET
Denmark

Aportación de la UE: EUR 716 468,75


ANKER ENGELUNDSVEJ 1 BYGNING 101 A
2800 KGS LYNGBY
Denmark
Activity type: Higher or Secondary Education Establishments

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KOBENHAVNS UNIVERSITET
Denmark

Aportación de la UE: EUR 747 320


NORREGADE 10
1165 KOBENHAVN
Denmark
Activity type: Higher or Secondary Education Establishments

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UNIVERSITY COLLEGE LONDON
United Kingdom

Aportación de la UE: EUR 111 732,50


GOWER STREET
WC1E 6BT LONDON
United Kingdom
Activity type: Higher or Secondary Education Establishments

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LUMICKS B.V.
Netherlands

Aportación de la UE: EUR 937 500


DE BOELELAAN 1081
1081HV AMSTERDAM
Netherlands
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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