Obiettivo CHROMAVISION aims to develop a pioneering chromosome imaging and manipulation platform that will fuel the next decades of structural chromosome research. Chromosomal abnormalities are characteristic of many disorders such as cancer, impaired fertility due to maternal aging, and neurological disorders such as fragile X syndrome. If humanity is to fully understand the wide range of diseases that are associated to errors in cell division, we must be able to further 'zoom in' on healthy and diseased chromosomes in all their complexity. The CHROMAVISION platform will allow molecular biologists to automatically isolate individual chromosomes from small tissue or cell samples and have these delivered to a super-resolution microscope. Chromosome isolation and delivery is achieved by an opto-fluidic chip that is able to trap, visualise and lyse individual cells and separate metaphase chromosomes from cell lysate. Single chromosomes can be “hand-selected” and brought into focus of the Super-Resolution Correlative Tweezers Fluorescence Microscope (CTFM-SR3D) that is developed in CHROMAVISION. This instrument will for the first time enable 3D, super-resolution, real-time metaphase chromosome observation and manipulation studies under near-physiological conditions. The technique will push the boundaries of what is currently possible in microfluidics and super-resolution microscopy and combine these into a single powerful approach for chromosome studies. Furthermore, the platform will be applied in CHROMAVISION to address key challenges in clinical and fundamental chromosome research, potentially resulting in breakthrough discoveries. Better imaging and understanding of the chromosomal mechanisms will contribute to our knowledge of the etiology of human diseases and aid drug discovery. The platform will also have large clinical value, allowing identification and monitoring of e.g. cancer heterogeneity. Campo scientifico natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural sciencesphysical sciencesopticsmicroscopysuper resolution microscopynatural sciencescomputer and information sciencessoftwaresoftware developmentnatural sciencesbiological sciencesgeneticschromosomes Parole chiave Super-resolution microscopy chromosomes imaging microfluidics lab-on-a-chip Programma(i) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Argomento(i) FETOPEN-RIA-2014-2015 - FET-Open research projects Invito a presentare proposte H2020-FETOPEN-2014-2015 Vedi altri progetti per questo bando Bando secondario H2020-FETOPEN-2014-2015-RIA Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore STICHTING VU Contribution nette de l'UE € 1 054 003,75 Indirizzo DE BOELELAAN 1105 1081 HV Amsterdam Paesi Bassi Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 054 003,75 Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto DANMARKS TEKNISKE UNIVERSITET Danimarca Contribution nette de l'UE € 716 468,75 Indirizzo ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby Mostra sulla mappa Regione Danmark Hovedstaden Københavns omegn Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 716 468,75 KOBENHAVNS UNIVERSITET Danimarca Contribution nette de l'UE € 747 320,00 Indirizzo NORREGADE 10 1165 Kobenhavn Mostra sulla mappa Regione Danmark Hovedstaden Byen København Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 747 320,00 UNIVERSITY COLLEGE LONDON Regno Unito Contribution nette de l'UE € 111 732,50 Indirizzo GOWER STREET WC1E 6BT London Mostra sulla mappa Regione London Inner London — West Camden and City of London Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 111 732,50 LUMICKS BV Paesi Bassi Contribution nette de l'UE € 937 500,00 Indirizzo PAALBERGWEG 3 1105 AG Amsterdam Mostra sulla mappa PMI L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione. Sì Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 937 500,00
