Project description DEENESFRITPL Revolutionising diagnostic tests During the processes of analysing and discovering new resistant pathogens and infectious diseases, diagnostic tests are crucial to reach efficient conclusions. Unfortunately, current diagnostic techniques utilise either cultivation or PCR, leading to severe disadvantages, often presenting trouble in characterising new pathogens during the 3-hour limit. The EU-funded MARA project aims to solve this problem by developing and introducing a revolutionary breakthrough based on three novel technologies, which will also demonstrate producing a DNA-based molecular toolkit for characterising pathogens. To achieve that, they will use the Autonomous Detection Nucleic Acids technology that doesn’t require sophisticated equipment, a novel breakthrough in protein mimicry and enzyme creation, and, finally, a molecular robot that can identify and destroy cells. Show the project objective Hide the project objective Objective Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistancenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Call for proposal H2020-FETOPEN-2014-2015 See other projects for this call Sub call H2020-FETOPEN-2014-2015-RIA Funding Scheme RIA - Research and Innovation action Coordinator AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Net EU contribution € 1 649 517,50 Address GIEFINGGASSE 4 1210 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 649 517,50 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany Net EU contribution € 581 250,00 Address FAHNENBERGPLATZ 79098 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 581 250,00 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom Net EU contribution € 647 250,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 647 250,00 APTA BIOSCIENCES LIMITED Participation ended United Kingdom Net EU contribution € 0,00 Address THE ELMS COURTYARD BROMSBERROW HR8 1RZ LEDBURY HEREFORDSHIRE See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Gloucestershire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data AARHUS UNIVERSITET Denmark Net EU contribution € 548 460,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 548 460,00 Pure Biologics Spolka Akcyjna Poland Net EU contribution € 570 000,00 Address UL DUNSKA 11 54-427 WROCLAW See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 570 000,00