The physics of antibiotic resistance evolution in spatially-structured multicellular assemblies

Project Information

EvoStruc

Grant agreement ID: 682237

DOI 10.3030/682237

Project closed

EC signature date 15 April 2016

Start date 1 June 2016

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 826 984,00

EU contribution € 1 826 984,00

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

Publications

Peer reviewed articles (14)

A roadblock-and-kill model explains the action of the DNA-targeting antibiotic ciprofloxacin

Author(s): Angela Dawson; Susana O. L. Direito; Nikola Ojkic; Nikola Ojkic; Rosalind J. Allen; Elin E. Lilja; Bartlomiej Waclaw
Published in: Antimicrobial Agents and Chemotherapy, Issue 2, 2019, ISSN 1098-6596
Publisher: American Society of Microbiology
DOI: 10.1101/791145

Computational design of probes to detect bacterial genomes by multivalent binding

Author(s): Tine Curk, Chris A. Brackley, James D. Farrell, Zhongyang Xing, Darshana Joshi, Susana Direito, Urban Bren, Stefano Angioletti-Uberti, Jure Dobnikar, Erika Eiser, Daan Frenkel, Rosalind J. Allen
Published in: Proceedings of the National Academy of Sciences, Issue 117/16, 2020, Page(s) 8719-8726, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1918274117

Predictable properties of fitness landscapes induced by adaptational tradeoffs

Author(s): Suman G Das, Susana OL Direito, Bartlomiej Waclaw, Rosalind J Allen, Joachim Krug
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55155

Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

Author(s): Martín Carballo-Pacheco, Michael D. Nicholson, Elin E. Lilja, Rosalind J. Allen, Bartlomiej Waclaw
Published in: PLOS Computational Biology, Issue 16/5, 2020, Page(s) e1007930, ISSN 1553-7358
Publisher: public library of science
DOI: 10.1371/journal.pcbi.1007930

Stability of β-lactam antibiotics in bacterial growth media

Author(s): Rebecca Brouwers, Hugh Vass, Angela Dawson, Tracey Squires, Sharareh Tavaddod, Rosalind J. Allen
Published in: PLOS ONE, Issue 15/7, 2020, Page(s) e0236198, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0236198

Antibiotic resistance: a physicist’s view

Author(s): Rosalind Allen, Bartłomiej Waclaw
Published in: Physical Biology, Issue 13/4, 2016, Page(s) 045001, ISSN 1478-3975
Publisher: Institute of Physics
DOI: 10.1088/1478-3975/13/4/045001

Predicting the dynamics of bacterial growth inhibition by ribosome-targeting antibiotics

Author(s): Philip Greulich, Jakub Doležal, Matthew Scott, Martin R Evans, Rosalind J Allen
Published in: Physical Biology, Issue 14/6, 2017, Page(s) 065005, ISSN 1478-3975
Publisher: Institute of Physics
DOI: 10.1088/1478-3975/aa8001

Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies (a)

Author(s): Craig Watson, Paul Hush, Joshua Williams, Angela Dawson, Nikola Ojkic, Simon Titmuss, Bartlomiej Waclaw
Published in: EPL (Europhysics Letters), Issue 123/6, 2018, Page(s) 68001, ISSN 1286-4854
Publisher: Institute of Physics
DOI: 10.1209/0295-5075/123/68001

Bacterial growth: a statistical physicist’s guide

Author(s): Rosalind J Allen, Bartlomiej Waclaw
Published in: Reports on Progress in Physics, Issue 82/1, 2019, Page(s) 016601, ISSN 0034-4885
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6633/aae546

Growth-dependent drug susceptibility can prevent or enhance spatial expansion of a bacterial population

Author(s): Patrick Sinclair, Martín Carballo-Pacheco, Rosalind J Allen
Published in: Physical Biology, Issue 16/4, 2019, Page(s) 046001, ISSN 1478-3975
Publisher: Institute of Physics
DOI: 10.1088/1478-3975/ab131e

Lineage dynamics in growing biofilms: spatial patterns of standing versus de novo diversity

Author(s): Ellen Young, Rosalind J Allen
Published in: Frontiers in Microbiology, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.915095

A simulation study of aggregation mediated by production of cohesive molecules

Author(s): Gavin Melaugh, Davide Marenduzzo, Alexander Morozov, Rosalind J. Allen
Published in: Soft Matter, Issue 15/44, 2019, Page(s) 9120-9132, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sm01462d

Staff and patient perceptions of a community urinary catheter service.

Author(s): Ellen Young; Freya C. Oswald; Fiona C. Denison; Rosalind J. Allen; Meghan Perry; Meghan Perry
Published in: Int J Urol Nurs, Issue 1, 2020, Page(s) 83-91, ISSN 1749-771X
Publisher: Wiley
DOI: 10.1111/ijun.12230

Tracking the stochastic growth of bacterial populations in microfluidic droplets

Author(s): Daniel Taylor, Nia Verdon, Peter Lomax, Rosalind J Allen, Simon Titmuss
Published in: Physical Biology, 2022, ISSN 1478-3975
Publisher: Institute of Physics
DOI: 10.1088/1478-3975/ac4c9b