The physics of antibiotic resistance evolution in spatially-structured multicellular assemblies

Informazioni relative al progetto

EvoStruc

ID dell’accordo di sovvenzione: 682237

DOI 10.3030/682237

Progetto chiuso

Data della firma CE 15 Aprile 2016

Data di avvio 1 Giugno 2016

Data di completamento 31 Maggio 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 826 984,00

Contributo UE € 1 826 984,00

Coordinato da

THE UNIVERSITY OF EDINBURGH
United Kingdom

Pubblicazioni

Peer reviewed articles (14)

A roadblock-and-kill model explains the action of the DNA-targeting antibiotic ciprofloxacin

Autori: Angela Dawson; Susana O. L. Direito; Nikola Ojkic; Nikola Ojkic; Rosalind J. Allen; Elin E. Lilja; Bartlomiej Waclaw
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 2, 2019, ISSN 1098-6596
Editore: American Society of Microbiology
DOI: 10.1101/791145

Computational design of probes to detect bacterial genomes by multivalent binding

Autori: Tine Curk, Chris A. Brackley, James D. Farrell, Zhongyang Xing, Darshana Joshi, Susana Direito, Urban Bren, Stefano Angioletti-Uberti, Jure Dobnikar, Erika Eiser, Daan Frenkel, Rosalind J. Allen
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/16, 2020, Pagina/e 8719-8726, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1918274117

Predictable properties of fitness landscapes induced by adaptational tradeoffs

Autori: Suman G Das, Susana OL Direito, Bartlomiej Waclaw, Rosalind J Allen, Joachim Krug
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55155

Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

Autori: Martín Carballo-Pacheco, Michael D. Nicholson, Elin E. Lilja, Rosalind J. Allen, Bartlomiej Waclaw
Pubblicato in: PLOS Computational Biology, Numero 16/5, 2020, Pagina/e e1007930, ISSN 1553-7358
Editore: public library of science
DOI: 10.1371/journal.pcbi.1007930

Stability of β-lactam antibiotics in bacterial growth media

Autori: Rebecca Brouwers, Hugh Vass, Angela Dawson, Tracey Squires, Sharareh Tavaddod, Rosalind J. Allen
Pubblicato in: PLOS ONE, Numero 15/7, 2020, Pagina/e e0236198, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0236198

Antibiotic resistance: a physicist’s view

Autori: Rosalind Allen, Bartłomiej Waclaw
Pubblicato in: Physical Biology, Numero 13/4, 2016, Pagina/e 045001, ISSN 1478-3975
Editore: Institute of Physics
DOI: 10.1088/1478-3975/13/4/045001

Predicting the dynamics of bacterial growth inhibition by ribosome-targeting antibiotics

Autori: Philip Greulich, Jakub Doležal, Matthew Scott, Martin R Evans, Rosalind J Allen
Pubblicato in: Physical Biology, Numero 14/6, 2017, Pagina/e 065005, ISSN 1478-3975
Editore: Institute of Physics
DOI: 10.1088/1478-3975/aa8001

Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies (a)

Autori: Craig Watson, Paul Hush, Joshua Williams, Angela Dawson, Nikola Ojkic, Simon Titmuss, Bartlomiej Waclaw
Pubblicato in: EPL (Europhysics Letters), Numero 123/6, 2018, Pagina/e 68001, ISSN 1286-4854
Editore: Institute of Physics
DOI: 10.1209/0295-5075/123/68001

Bacterial growth: a statistical physicist’s guide

Autori: Rosalind J Allen, Bartlomiej Waclaw
Pubblicato in: Reports on Progress in Physics, Numero 82/1, 2019, Pagina/e 016601, ISSN 0034-4885
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6633/aae546

Growth-dependent drug susceptibility can prevent or enhance spatial expansion of a bacterial population

Autori: Patrick Sinclair, Martín Carballo-Pacheco, Rosalind J Allen
Pubblicato in: Physical Biology, Numero 16/4, 2019, Pagina/e 046001, ISSN 1478-3975
Editore: Institute of Physics
DOI: 10.1088/1478-3975/ab131e

Lineage dynamics in growing biofilms: spatial patterns of standing versus de novo diversity

Autori: Ellen Young, Rosalind J Allen
Pubblicato in: Frontiers in Microbiology, 2022, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2022.915095

A simulation study of aggregation mediated by production of cohesive molecules

Autori: Gavin Melaugh, Davide Marenduzzo, Alexander Morozov, Rosalind J. Allen
Pubblicato in: Soft Matter, Numero 15/44, 2019, Pagina/e 9120-9132, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sm01462d

Staff and patient perceptions of a community urinary catheter service.

Autori: Ellen Young; Freya C. Oswald; Fiona C. Denison; Rosalind J. Allen; Meghan Perry; Meghan Perry
Pubblicato in: Int J Urol Nurs, Numero 1, 2020, Pagina/e 83-91, ISSN 1749-771X
Editore: Wiley
DOI: 10.1111/ijun.12230

Tracking the stochastic growth of bacterial populations in microfluidic droplets

Autori: Daniel Taylor, Nia Verdon, Peter Lomax, Rosalind J Allen, Simon Titmuss
Pubblicato in: Physical Biology, 2022, ISSN 1478-3975
Editore: Institute of Physics
DOI: 10.1088/1478-3975/ac4c9b