Microtechnology and integrated microsystems to investigate neuronal networks across scales

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Author(s): T. Gänswein. S. S. Kumar, A. Buccino, X. Xue, J. Bartram, V. Emmenegger, A. Hierlemann
Published in: 2022
Publisher: NMI

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Author(s): Fiscella, Michele; Leary, Noelle; Acun, Ebru; Ronchi, Silvia; Hierlemann, Andreas
Published in: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays, Issue 9, 2018
Publisher: Frontiers
DOI: 10.3929/ethz-b-000322066

Functional characterization of axons in human iPSC-derived neurons modeling brain diseases by high-density microelectrode arrays

Author(s): Fiscella, Michele; Ronchi, Silvia; Prack, Gustavo; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: ISSCR 2020 Poster Abstract Guide, Issue 3, 2020
Publisher: ISSCR
DOI: 10.3929/ethz-b-000473626

High-throughput ground-truth validation of neuronal spike sorting algorithms

Author(s): X. Xue, A. Buccino, S. Kumar, A. Hierlemann, J. Bartram
Published in: 2022
Publisher: NMI

DeePhys, a machine learning-driven platform for electrophysiological phenotype screening of human stem-cell derived neuronal networks

Author(s): P. Hornauer, G. Prack, N. Anastasi, S. Ronchi, T. Kim, C. Donner, M. Fiscella, K. Borgwardt, V. Taylor, R. Jagasia, D. Roqueiro, A. Hierlemann, M. Schröter
Published in: 2022
Publisher: NMI

Paired spine Ca2+ imaging and large-scale extracellular HD-MEA recordings for the identification of monosynaptic connections

Author(s): X. Xue, A. Buccino, S. Kumar, A. Hierlemann, J. Bartram
Published in: 2022
Publisher: EMBO

Exploring the feasibility of tracking axon initial segment plasticity by means of high-resolution extracellular electrophysiology

Author(s): T. Gänswein. S. S. Kumar, A. Buccino, V. Emmenegger, A. Hierlemann
Published in: 51st Annual Meeting of the Society for Neuroscience, 2022
Publisher: SfN

Electrophysiological characterization of α-synuclein function in human iPSC-derived dopaminergic neurons using high-density microelectrode arrays

Author(s): Hornauer, Philipp; Prack, Gustavo; Fiscella, Michele; Donner, Christian; Roqueiro, Damian Sabas; id_orcid0000-0002-9195-5915; Taylor, Verdon; Borgwardt, Karsten; Hierlemann, Andreas; id_orcid0000-0002-3838-2468; Schröter, Manuel
Published in: ISSCR 2020 Poster Abstract Guide, Issue 8, 2020
Publisher: ISCCR

Integration of Discrete Sensors and Microelectrode Arrays Into Open Microfluidic Hanging-Drop Networks

Author(s): Raziyeh Bounik, Massimiliano Gusmaroli, Patrick M. Misun, Vijay Viswam, Andreas Hierlemann, Mario M. Modena
Published in: 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS), 2019, Page(s) 441-444, ISBN 978-1-7281-1610-5
Publisher: IEEE
DOI: 10.1109/memsys.2019.8870732

A novel multimodal approach for probing synaptic connectivity and properties

Author(s): Xue, Xiaohan Buccino, Alessio Paolo Kumar, Sreedhar Saseendran Hierlemann, Andreas Bartram, Julian
Published in: 2022
Publisher: Federation of European Neuroscience Societies

A modulated template-matching approach to improve spike sorting of bursting neurons

Author(s): Payam S. Shabestari; Alessio P. Buccino; Sreedhar S. Kumar; Alessandra Pedrocchi; Andreas Hierlemann
Published in: IEEE Biomed Circuits Syst Conf, 2021
Publisher: IEEE
DOI: 10.1109/biocas49922.2021.9644995

High-density mapping of brain slices using a large multi-functional high-density CMOS microelectrode array system

Author(s): Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
Published in: 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2017, Page(s) 135-138, ISBN 978-1-5386-2732-7
Publisher: IEEE
DOI: 10.1109/TRANSDUCERS.2017.7994006

Acquisition of bioelectrical signals with small electrodes

Author(s): Vijay Viswam, Marie Obien, Urs Frey, Felix Franke, Andreas Hierlemann
Published in: 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2017, Page(s) 1-4, ISBN 978-1-5090-5803-7
Publisher: IEEE
DOI: 10.1109/BIOCAS.2017.8325216

Direct interfacing of neurons to highly integrated microsystems

Author(s): Andreas Hierlemann
Published in: 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS), 2017, Page(s) 199-204, ISBN 978-1-5090-5078-9
Publisher: IEEE
DOI: 10.1109/MEMSYS.2017.7863375

High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons

Author(s): Fiscella, Michele; Müller, Jan; Hierlemann, Andreas
Published in: Poster Abstract Book ISSCR 2017, Issue 1, 2017
Publisher: ISSCR

Single-Cell Electrical Stimulation with CMOS-based High-Density Microelectrode Arrays

Author(s): Silvia Ronchi, Michele Fiscella, Jan Müller, Vijay Viswam, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00086

Mapping neuronal network dynamics in developing cerebral organoids

Author(s): Manuel Schröter, Monika Girr, Julia Boos, Magdalena Renner, Mahshid Gazorpak, Wei Gong, Julian Bartram, Jan Müller, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00066

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation

Author(s): Xinyue Yuan, Andreas Hierlemann, Urs Frey
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00088

Mechanisms of homeostatic synaptic plasticity

Author(s): Bartram, Julian; Schröter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Müller, Jan; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 7, 2018
Publisher: Society for Neuroscience

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array

Author(s): Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 7, 2018
Publisher: Society for Neuroscience

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays

Author(s): Ronchi, Silvia; Fiscella, Michele; Marchetti, C.; Viswam, Vijay; Müller, Jan; Frey, Urs; id_orcid0000-0003-4026-1259; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 1, 2018
Publisher: Society for Neuroscience

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Author(s): Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Poster Abstract Book of the ISSCR 2018 Annual Meeting, Issue 6, 2018
Publisher: International Society for Stem Cell Research

ELECTROPHYSIOLOGICAL PHENOTYPE CHARACTERIZATION OF HUMAN IPSC-DERIVED DOPAMINERGIC NEURONAL LINES BY MEANS OF HIGH-RESOLUTION MICROELECTRODE ARRAYS

Author(s): Michele Fiscella, Noelle Leary, Ebru Acun, Silvia Ronchi, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00014

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Author(s): Marie Engelene Obien, Giulio Zorzi, Michele Fiscella, Noelle Leary, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00095

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons

Author(s): Giulio Zorzi, Marie Engelene Obien, Michele Fiscella, Noelle Leary, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00049

Effective benchmarking of high-density MEA spike-sorters

Author(s): Roland Diggelmann, Andreas Hierlemann, Felix Franke
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00092

Investigating the analog modulation of action-potential waveforms in axonal arbors of cortical neurons using whole-cell patch-clamp recordings and high-density microelectrode arrays

Author(s): V. Emmenegger, J. Bartram, S. Sitnikov, A. Hierlemann
Published in: Neuroscience 2018 Abstracts, 2018
Publisher: Society for Neuroscience

Dual-mode Microelectrode Array Featuring 20k Electrodes and High SNR for Extracellular Recording of Neural Networks

Author(s): Xinyue Yuan, Vishalini Emmenegger, Marie Engelene J. Obien, Andreas Hierlemann, Urs Frey
Published in: 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2018, Page(s) 1-4, ISBN 978-1-5386-3603-9
Publisher: IEEE
DOI: 10.1109/biocas.2018.8584735

Spontaneous neuronal activity in developing mouse cerebral organoids

Author(s): M. Girr, J. Boos, P. Misun, J. Bartram, M. Renner, M. Gazorpak, A. Hierlemann, M. Schröter
Published in: Neuroscience 2018 Abstracts, 2018
Publisher: Society for Neuroscience

Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings

Author(s): Julian Bartram, Manuel Schröter, Silvia Ronchi, Vishalini Emmenegger, Jan Müller, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/conf.fncel.2018.38.00085

Pre-whitening as a means to improve dimensionality reduction and simplify clustering in spike-sorters for multi-electrode recordings

Author(s): R. Diggelmann, M. Fiscella, A. Hierlemann, F. Franke
Published in: 26th Annual Computational Neuroscience Meeting (CNS2017), July 15-20, 2017, Antwerp, Belgium, 2017, ISSN 1471-2202
Publisher: BMC Neuroscience, Springer Nature

How the coupling strength of horizontal cells effects the retinal processing of spatio-temporal light stimuli - Model and experiments

Author(s): Bucci, Annalisa Diggelmann, Roland Znidaric, Matej Roska, Botond da Silveira, Rava Hierlemann, Andreas Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019
Publisher: Society for Neuroscience (SfN)

Machine learning for deep electrophysiological phenotyping of human dopaminergic neurons

Author(s): Schröter, Manuel Roqueiro, Damian Sabas Prack, Gustavo Fiscella, Michele Borgwardt, Karsten Hierlemann, Andreas
Published in: International Society for Stem Cell Research Annual Meeting (ISSCR 2019), Los Angeles, CA, USA, June 26-29, 2019, 2019
Publisher: International Society of Stem Cell Research

Ex vivo mouse retinal recordings using HD-MEA systems: From characterizing single cells to analyzing populations

Author(s): Znidaric, Matejcc Diggelmann, Roland Bucci, Annalisa Hierlemann, Andreascc Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019
Publisher: Society for Neuroscience (SfN)

Investigating dendritic signals evoked by natural patterns of presynaptic activity

Author(s): Xue, Xiaohan Lummen, Tom T.A. Hierlemann, Andreas Bartram, Julian
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019
Publisher: Society for Neuroscience (SfN)

Electrophysiological Phenotype Characterization of Human iPSC-derived Neuronal-Cell Lines by Means of High-Resolution Microelectrode Arrays

Author(s): Fiscella, Michele Zorzi, Giulio Ronchi, Silvia Prack, Gustavo Schröter, Manuel Hierlemann, Andreas
Published in: International Society for Stem Cell Research Annual Meeting (ISSCR 2019), Los Angeles, CA, USA, June 26-29, 2019, 2019
Publisher: International Society of Stem Cell Research

Connectivity profiling and single-cell RNA sequencing to study homeostatic plasticity in hippocampal neuronal networks in vitro

Author(s): Kim, Taehoon Bartram, Julian Hierlemann, Andreas Schröter, Manuel
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019
Publisher: Society for Neuroscience (SfN)

Improved receptive-field characterization of retinal ganglion cells using a large field-of-view light stimuli

Author(s): Diggelmann, Roland Znidaric, Matej Bucci, Annalisa Hierlemann, Andreas Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting, Chicago, IL, USA, October 19-23, 2019, 2019
Publisher: Society for Neuroscience (SfN)

A new CMOS-electrode-array-based impedance sensor integrated into an open microfluidic platform

Author(s): R. Bounik, F. Cardes, V. Viswam, M. M. Modena, A. Hierlemann
Published in: 2022
Publisher: NMI

A CMOS Microelectrode Array Integrated into an Open, Continuously Perfused Microfluidic System

Author(s): R. Bounik, J. Lee, V. Viswam , F. Cardes, M. M. Modena, A. Hierlemann
Published in: 2022
Publisher: IEEE

Impedance Measurements and Electrophysiological Recordings of Mouse Retinae on a Multifunctional HD-MEA Platform

Author(s): H. Ulusan, R. Diggelmann, C. Magnan, M. Znidaric, V. Viswam, F. Franke, and A. Hierlemann
Published in: 2022
Publisher: NMI

Propagation speeds of action potentials in the human retina compensate for traveling distances

Author(s): "A. Bucci, R. Diggelmann, M. Znidaric, M. De Gennaro, C. Cowan, B. Roska, A. Hierlemann, F. Franke, """", Vision Sciences Annual meeting, May 13-18, 2022, St. Pete Beach, Florida, USA. Online"
Published in: 2022
Publisher: Vision Science Society

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation

Author(s): P. Hornauer, G. Prack, N. Anastasi, S. Ronchi, T. Kim, C. Donner, M. Fiscella, K. Borgwardt, V. Taylor, R. Jagasia, D. Roqueiro, A. Hierlemann, M. Schröter
Published in: 51st Annual Meeting of the Society for Neuroscience, 2022
Publisher: SfN

Functional characterization of human iPSC-derived neuronal networks using high-density microelectrode arrays

Author(s): Ronchi, Silvia; Prack, Gustavo; Fiscella, Michele; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: ISSCR 2020 Poster Abstract Guide, Issue 1, 2020
Publisher: ISSCR
DOI: 10.3929/ethz-b-000466353

Electrochemical Measurement Platform within Multi-functional High-density Microelectrode Array

Author(s): Magnan, Chloé Ulusan, Hasan Diggelmann, Roland Hierlemann, Andreas
Published in: 2022
Publisher: NMI

Comparison of connectivity inference algorithms for classification of neuronal cultures using graph kernels

Author(s): Kim, Taehoon; Hornauer, Philipp; Donner, Christian; Hierlemann, Andreas; id_orcid0000-0002-3838-2468; Borgwardt, Karsten; Schröter, Manuel; Roqueiro, Damian Sabas; id_orcid0000-0002-9195-5915
Published in: ECML PKDD Workshop on Machine Learning for Pharma and Healthcare Applications, Issue 5, 2020
Publisher: PharmML
DOI: 10.3929/ethz-b-000466325

Extracellular Recording of Entire Neural Networks Using a Dual-Mode Microelectrode Array With 19,584 Electrodes and High SNR

Author(s): Xinyue Yuan, Andreas Hierlemann, Urs Frey
Published in: IEEE Journal of Solid-State Circuits, 2021, Page(s) 1-1, ISSN 0018-9200
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jssc.2021.3066043

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Author(s): S. Kumar, T. Gänswein, A. Buccino, X. Xue, J. Bartram, V. Emmenegger, A. Hierlemann
Published in: Frontiers in Neuroinformatics, Issue 16624548, 2022, Page(s) Article 957255, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fninf.2022.957255

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Author(s): Tal Sharf; Tjitse van der Molen; Stella M. K. Glasauer; Elmer Guzman; Alessio P. Buccino; Gabriel Luna; Zhuowei Cheng; Morgane Audouard; Kamalini G. Ranasinghe; Kiwamu Kudo; Srikantan S. Nagarajan; Kenneth R. Tovar; Linda R. Petzold; Andreas Hierlemann; Paul K. Hansma; Kenneth S. Kosik
Published in: Nature Communications, 13 (1), Issue 20411723, 2022, Page(s) Article 4403, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32115-4

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Author(s): Xue, Xiaohan; id_orcid0000-0001-5398-2368; Buccino, Alessio Paolo; id_orcid0000-0003-3661-527X; Kumar, Sreedhar Saseendran; Hierlemann, Andreas; id_orcid0000-0002-3838-2468; Bartram, Julian
Published in: Journal of Neural Engineering, 19 (4), Issue 17412560, 2022, Page(s) Article 046044, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.3929/ethz-b-000567411

A low‐power opamp‐less second‐order delta‐sigma modulator for bioelectrical signals in 0.18 μm cmos

Author(s): Cardes Garcia, Fernando; id_orcid0000-0003-1880-6734; Baladari, Nikhita; Lee, Jihyun; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Sensors, 21 (19), Issue 14248220, 2021, Page(s) 6456, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000507990

Impedance Imaging of Cells and Tissues: Design and Applications

Author(s): R. Bounik, F. Cardes, H. Ulusan, M. Modena, A. Hierlemann,
Published in: BME Frontiers, Issue 27658031, 2022, Page(s) Article ID 9857485, ISSN 2765-8031
Publisher: CAS
DOI: 10.34133/2022/9857485

An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays

Author(s): Alessio Paolo Buccino; Xinyue Yuan; Vishalini Emmenegger; Xiaohan Xue; Tobias Gänswein; Andreas Hierlemann
Published in: Journal of Neural Engineering, 19 (2), Issue 17412560, 2022, Page(s) 026026, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac59a2

Functional imaging of brain organoids using high-density microelectrode arrays

Author(s): M. Schröter, C. Wang, M. Terrigno, P. Hornauer, Z. Huang, R. Jagasia, A. Hierlemann
Published in: MRS Bulletin, Issue 08837694, 2022, ISSN 0883-7694
Publisher: Materials Research Society
DOI: 10.1557/s43577-022-00282-w

Massively parallel microwire arrays integrated with CMOS chips for neural recording

Author(s): Abdulmalik Obaid, Mina-Elraheb Hanna, Yu-Wei Wu, Mihaly Kollo, Romeo Racz, Matthew R. Angle, Jan Müller, Nora Brackbill, William Wray, Felix Franke, E. J. Chichilnisky, Andreas Hierlemann, Jun B. Ding, Andreas T. Schaefer, Nicholas A. Melosh
Published in: Science Advances, Issue 6/12, 2020, Page(s) eaay2789, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aay2789

Electrophysiological Phenotype Characterization of Human iPSC‐Derived Neuronal Cell Lines by Means of High‐Density Microelectrode Arrays

Author(s): Silvia Ronchi, Alessio Paolo Buccino, Gustavo Prack, Sreedhar Saseendran Kumar, Manuel Schröter, Michele Fiscella, Andreas Hierlemann
Published in: Advanced Biology, Issue 5/3, 2021, Page(s) 2000223, ISSN 2701-0198
Publisher: Wiley VCH
DOI: 10.1002/adbi.202000223

Multiple Single-Unit Long-Term Tracking on Organotypic Hippocampal Slices Using High-Density Microelectrode Arrays

Author(s): Wei Gong, Jure Senčar, Douglas J. Bakkum, David Jäckel, Marie Engelene J. Obien, Milos Radivojevic, Andreas R. Hierlemann
Published in: Frontiers in Neuroscience, Issue 10, 2016, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2016.00537

Tracking individual action potentials throughout mammalian axonal arbors

Author(s): Milos Radivojevic, Felix Franke, Michael Altermatt, Jan Müller, Andreas Hierlemann, Douglas J Bakkum
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.30198

<italic>In Vitro</italic> Multi-Functional Microelectrode Array Featuring 59 760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement, and Neurotransmitter Detection Channels

Author(s): Jelena Dragas, Vijay Viswam, Amir Shadmani, Yihui Chen, Raziyeh Bounik, Alexander Stettler, Milos Radivojevic, Sydney Geissler, Marie Engelene J. Obien, Jan Muller, Andreas Hierlemann
Published in: IEEE Journal of Solid-State Circuits, Issue 52/6, 2017, Page(s) 1576-1590, ISSN 0018-9200
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/JSSC.2017.2686580

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials

Author(s): Milos Radivojevic, David Jäckel, Michael Altermatt, Jan Müller, Vijay Viswam, Andreas Hierlemann, Douglas J. Bakkum
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep31332

Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration

Author(s): David Jäckel, Douglas J. Bakkum, Thomas L. Russell, Jan Müller, Milos Radivojevic, Urs Frey, Felix Franke, Andreas Hierlemann
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-00981-4

Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems

Author(s): Mario M. Modena, Ketki Chawla, Patrick M. Misun, Andreas Hierlemann
Published in: ACS Chemical Biology, 2018, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.7b01029

Automatic spike sorting for high-density microelectrode arrays

Author(s): Roland Diggelmann, Michele Fiscella, Andreas Hierlemann, Felix Franke
Published in: Journal of Neurophysiology, Issue 120/6, 2018, Page(s) 3155-3171, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00803.2017

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays

Author(s): Marie Engelene J. Obien, Andreas Hierlemann, Urs Frey
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-36895-y

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry

Author(s): Alexandra Dudina, Florent Seichepine, Yihui Chen, Alexander Stettler, Andreas Hierlemann, Urs Frey
Published in: Sensors and Actuators B: Chemical, Issue 279, 2019, Page(s) 255-266, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2018.10.004

Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System

Author(s): Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Cedar Urwyler, Julia Alicia Boos, Marie Engelene J. Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
Published in: IEEE Transactions on Biomedical Circuits and Systems, Issue 12/6, 2018, Page(s) 1356-1368, ISSN 1932-4545
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbcas.2018.2881044

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Author(s): Silvia Ronchi, Michele Fiscella, Camilla Marchetti, Vijay Viswam, Jan Müller, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Neuroscience, Issue 13, 2019, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2019.00208

Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation

Author(s): T. Russell, J. Zhang, M. Okoniewski, F. Franke, S. Bichet, A. Hierlemann
Published in: Frontiers in Neuroscience, 2019, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2019.00376

Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies

Author(s): Vijay Viswam, Marie Engelene J. Obien, Felix Franke, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Neuroscience, Issue 13, 2019, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2019.00385

Stimulation and Artifact-suppression Techniques for in-vitro High-density Microelectrode Array Systems

Author(s): Amir Shadmani, Vijay Viswam, Yihui Chen, Raziyeh Bounik, Jelena Dragas, Milos Radivojevic, Sydney Geissler, Sergey Sitnikov, Jan Muller, Andreas Hierlemann
Published in: IEEE Transactions on Biomedical Engineering, 2018, Page(s) 1-1, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2018.2890530

How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse

Author(s): Antonia Drinnenberg, Felix Franke, Rei K. Morikawa, Josephine Jüttner, Daniel Hillier, Peter Hantz, Andreas Hierlemann, Rava Azeredo da Silveira, Botond Roska
Published in: Neuron, Issue 99/1, 2018, Page(s) 117-134.e11, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.06.001

The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape

Author(s): Douglas J. Bakkum, Marie Engelene J. Obien, Milos Radivojevic, David Jäckel, Urs Frey, Hirokazu Takahashi, Andreas Hierlemann
Published in: Advanced Biosystems, Issue 3/2, 2019, Page(s) 1800308, ISSN 2366-7478
Publisher: Wiley
DOI: 10.1002/adbi.201800308

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs

Author(s): Vishalini Emmenegger, Marie Engelene J. Obien, Felix Franke, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 13, 2019, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00159

Carbon-Nanotube-Based Monolithic CMOS Platform for Electrochemical Detection of Neurotransmitter Glutamate

Author(s): Alexandra Dudina, Urs Frey, Andreas Hierlemann
Published in: Sensors, Issue 19/14, 2019, Page(s) 3080, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s19143080

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

Author(s): Torsten Bullmann, Milos Radivojevic, Stefan T. Huber, Kosmas Deligkaris, Andreas Hierlemann, Urs Frey
Published in: Frontiers in Cellular Neuroscience, Issue 13, 2019, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00404

Multisite Dopamine Sensing With Femtomolar Resolution Using a CMOS Enabled Aptasensor Chip

Author(s): V. Sessi, B. Ibarlucea, F. Seichepine, S. Klinghammer, I. Ibrahim, A. Heinzig, N. Szabo, T. Mikolajick, A. Hierlemann, U. Frey, W. Weber, L. Baraban, G. Cuniberti
Published in: Frontiers in Neuroscience, Issue 16624548, 2022, Page(s) Article 875656, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2022.875656

A 15-Channel 30-V Neural Stimulator for Spinal Cord Repair

Author(s): Yonghong Tao, Andreas Hierlemann
Published in: IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Issue 26/10, 2018, Page(s) 2185-2189, ISSN 1063-8210
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvlsi.2018.2832051

CHIME: CMOS-Hosted in vivo Microelectrodes for Massively Scalable Neuronal Recordings

Author(s): Mihaly Kollo, Romeo Racz, Mina-Elraheb Hanna, Abdulmalik Obaid, Matthew R. Angle, William Wray, Yifan Kong, Jan Müller, Andreas Hierlemann, Nicholas A. Melosh, Andreas T. Schaefer
Published in: Frontiers in Neuroscience, Issue 14, 2020, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2020.00834

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

Author(s): Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, Michele Fiscella, Wei Gong, Tetsuhiro Kikuchi, Aoi Odawara, Shuhei Noji, Ikuro Suzuki, Jun Takahashi, Andreas Hierlemann, Urs Frey
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18620-4

A CMOS-based highly scalable flexible neural electrode interface

Author(s): Eric T. Zhao, Jacob Hull, Nofar Mintz Hemed, Hasan Uluşan, Julian Bartram, Anqi Zhang, Pingyu Wang, Albert Pham, Silvia Ronchi, John R. Huguenard, Andreas Hierlemann, Nicholas A. Melosh
Published in: 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.03.514455

Homophilic wiring principles underpin neuronal network topology in vitro

Author(s): Danyal Akarca, Alexander WE Dunn, Philipp J Hornauer, Silvia Ronchi, Michele Fiscella, Congwei Wang, Marco Terrigno, Ravi Jagasia, Petra E Vértes, Susanna B Mierau, Ole Paulsen, Stephen J Eglen, Andreas Hierlemann, Duncan E Astle, Manuel Schröter
Published in: 2022
Publisher: BioRxiv
DOI: 10.1101/2022.03.09.483605

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation

Author(s): Philipp Hornauer, Gustavo Prack, Nadia Anastasia, Silvia Ronchi, Taehoon Kim, Christian Donner, Michele Fiscella, Karsten Borgwardt, Verdon Taylor, Ravi Jagasia, Damian Roqueiro, Andreas Hierlemann, Manuel Schroeter
Published in: 2022
Publisher: BioRxiv
DOI: 10.1101/2022.03.31.486582

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Author(s): Alessio Paolo Buccino, Tanguy Damart, Julian Bartram, Darshan Mandge, Xiaohan Xue, Mickael Zbili, Tobias Gänswein, Aurelién Jaquier, Vishalini Emmenegger, Henry Markram, Andreas Hierlemann, Werner Van Geit
Published in: 2022
Publisher: BioRxiv
DOI: 10.1101/2022.08.03.502468

Electrical Stimulation and Functional Characterization of Neurons Using High-Density Microelectrode Arrays

Author(s): S. Ronchi
Published in: 2021
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000503238

From selective stimulation to single-spike detection: interfacing neocortical neurons with thousands of microelectrodes at subcellular spatial resolution

Author(s): Radivojevic, Milos
Published in: Issue 3, 2017
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000172841

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