Targeting iNKT cell and adipocyte crosstalk for control of metabolism and body weight

Project Information

FAT NKT

Grant agreement ID: 679173

DOI 10.3030/679173

Project closed

EC signature date 24 August 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 804 052,00

EU contribution € 1 804 052,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Publications

Peer reviewed articles (10)

Immune and non-immune functions of adipose tissue leukocytes

Author(s): William Trim, Lydia Lynch
Published in: Nature Reviews in Immunology, 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-021-00635-7

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

Author(s): Nelson M. LaMarche, Harry Kane, Ayano C. Kohlgruber, Han Dong, Lydia Lynch, Michael B. Brenner
Published in: Cell Metabolism, Issue 32/2, 2020, Page(s) 243-258.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.017

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

Author(s): Lydia Lynch, Andrew E. Hogan, Danielle Duquette, Chantel Lester, Alexander Banks, Katherine LeClair, David E. Cohen, Abhisek Ghosh, Bing Lu, Michelle Corrigan, Darko Stevanovic, Eleftheria Maratos-Flier, Daniel J. Drucker, Donal O’Shea, Michael Brenner
Published in: Cell Metabolism, Issue 24/3, 2016, Page(s) 510-519, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2016.08.003

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

Author(s): Selma Boulenouar, Xavier Michelet, Danielle Duquette, David Alvarez, Andrew E. Hogan, Christina Dold, Donal O’Connor, Suzanne Stutte, Ali Tavakkoli, Desmond Winters, Mark A. Exley, Donal O’Shea, Michael B. Brenner, Ulrich von Andrian, Lydia Lynch
Published in: Immunity, Issue 46/2, 2017, Page(s) 273-286, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2017.01.008

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Author(s): Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette, Hung N. Nguyen, Amir I. Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Alexander S. Banks, Tal Shay, Michael B. Brenner, Lydia Lynch
Published in: Nature Immunology, Issue 19/5, 2018, Page(s) 464-474, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0094-2

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Author(s): Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay, Lydia Lynch
Published in: Nature Immunology, Issue 19/12, 2018, Page(s) 1330-1340, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0251-7

Innate Immune Control of Adipose Tissue Homeostasis

Author(s): Harry Kane, Lydia Lynch
Published in: Trends in Immunology, Issue 40/9, 2019, Page(s) 857-872, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2019.07.006

Adipose Dendritic Cells Come Out of Hiding

Author(s): Nelson M. LaMarche, Lydia Lynch
Published in: Cell Metabolism, Issue 27/3, 2018, Page(s) 485-486, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.02.014

New Job for NK Cells: Architects of the Tumor Microenvironment

Author(s): Lydia Dyck, Lydia Lynch
Published in: Immunity, Issue 48/1, 2018, Page(s) 9-11, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.01.001

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Author(s): Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau, Nital Sumaria, Ayano C. Kohlgruber, Gina J. Fiala, Leandro Z. Agudelo, Lydia Dyck, Harry Kane, Aaron Douglas, Stephen Cunningham, Hannah Prendeville, Roisin Loftus, Colleen Carmody, Philippe Pierre, Manolis Kellis, Michael Brenner, Rafael J. Argüello, Bruno Silva-Santos, Daniel J. Pennington, Lydia Lynch
Published in: Nature Immunology, Issue 22/2, 2021, Page(s) 179-192, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-00848-3