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New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products

New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products

Objective

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 306 000

Participants (10)

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TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 450 000

JENABIOS GMBH

Germany

EU Contribution

€ 244 000

FIRMENICH SA

Switzerland

AVA BIOCHEM BSL AG

Switzerland

NOVOZYMES A/S

Denmark

TECHNISCHE UNIVERSITEIT DELFT

Netherlands

EU Contribution

€ 400 000

CHIRACON GMBH

Germany

EU Contribution

€ 250 000

CLEA TECHNOLOGIES BV

Netherlands

AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS

Spain

EU Contribution

€ 150 000

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 200 000

Project information

Grant agreement ID: 720297

Status

Ongoing project

  • Start date

    1 November 2016

  • End date

    31 October 2019

Funded under:

H2020-EU.3.2.6.

  • Overall budget:

    € 5 000 000

  • EU contribution

    € 3 000 000

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain