Skip to main content

Directed Protein Evolution for Synthetic Biology and Biocatalysis

Objective

ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein
sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how
enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical
analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.

Field of science

  • /natural sciences/biological sciences/synthetic biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /social sciences/economics and business/economics/health economics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 273 287,88

Participants (9)

UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 498 432,96
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
EU contribution
€ 232 422,48
Address
Pekarska 53
656 91 Brno
Activity type
Higher or Secondary Education Establishments
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 498 432,96
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
ENANTIS SRO
Czechia
EU contribution
€ 232 422,48
Address
Kamenice 771/34
625 00 Brno
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 510 748,56
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 260 300,52
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
MEDIMMUNE LIMITED
United Kingdom
EU contribution
€ 546 575,76
Address
Milstein Building Granta Park
CB21 6GH Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JOHNSON MATTHEY PLC
United Kingdom
EU contribution
€ 273 287,88
Address
Farringdon Street 25 5Th Floor
EC4A 4AB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 501 120
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments

Partners (9)

DROP-TECH LTD
United Kingdom
Address
Canterbury Street, Canterbury Court 91
CB4 3QU Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENZYMICALS AG
Germany
Address
Walther-rathenau-strasse 49A
17489 Greifswald
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kamada
Israel
Address
7 Sapir St., Kiryat Weizmann Science Park, P.o 4081, 7414002
Ness-ziona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DSM FOOD SPECIALTIES BV
Netherlands
Address
Alexander Fleminglaan 1
2613 AX Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAMBRIDGE ENTREPRISE LIMITED
United Kingdom
Address
Charles Babbage Road Hauser Forum 3
CB3 0GT Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Alzheimer's Research UK
United Kingdom
Address
43-44 Crutched Friars
EC3N 2AE London
Activity type
Other
NOVOZYMES A/S
Denmark
Address
Krogshoejvej 36
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Brain AG
Germany
Address
Darmstädter Straße 34-36
64673 Zwingenberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)