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Directed Protein Evolution for Synthetic Biology and Biocatalysis

Objective

ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein
sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how
enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical
analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 273 287,88
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (9)

UNIVERSITAET GREIFSWALD
Germany
Net EU contribution
€ 498 432,96
Address
Domstrasse 11
17489 Greifswald

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
Net EU contribution
€ 232 422,48
Address
Pekarska 53
656 91 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
Net EU contribution
€ 498 432,96
Address
Schlossplatz 2
48149 Muenster

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Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ENANTIS SRO
Czechia
Net EU contribution
€ 232 422,48
Address
Kamenice 771/34
625 00 Brno

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Jihovýchod Jihomoravský kraj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
Net EU contribution
€ 510 748,56
Address
Broerstraat 5
9712CP Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
Net EU contribution
€ 260 300,52
Non-EU contribution
€ 0,00
MEDIMMUNE LIMITED
United Kingdom
Net EU contribution
€ 546 575,76
Address
Milstein Building Granta Park
CB21 6GH Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
JOHNSON MATTHEY PLC
United Kingdom
Net EU contribution
€ 273 287,88
Address
Farringdon Street 25 5th Floor
EC4A 4AB London

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Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Net EU contribution
€ 501 120,00
Address
Place De L Universite 1
1348 Louvain La Neuve

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Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (9)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

DROP-TECH LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Canterbury Street, Canterbury Court 91
CB4 3QU Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ENZYMICALS AG
Germany
Net EU contribution
€ 0,00
Address
Walther-rathenau-strasse 49a
17489 Greifswald

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Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Net EU contribution
€ 0,00
Address
Great West Road 980
TW89GS Brentford

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Region
London Outer London — West and North West Hounslow and Richmond upon Thames
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Kamada LTD
Israel
Net EU contribution
€ 0,00
Address
7 Sapir St., Kiryat Weizmann Science Park, P.o 4081, 7414002
Ness-ziona

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

DSM FOOD SPECIALTIES BV
Netherlands
Net EU contribution
€ 0,00
Address
Alexander Fleminglaan 1
2613 AX Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CAMBRIDGE ENTREPRISE LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Charles Babbage Road Hauser Forum 3
CB3 0GT Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ALZHEIMER'S SOCIETY
United Kingdom
Net EU contribution
€ 0,00
Address
43-44 Crutched Friars
EC3N 2AE London

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Region
London Inner London — West Camden and City of London
Activity type
Other
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NOVOZYMES A/S
Denmark
Net EU contribution
€ 0,00
Address
Krogshoejvej 36
2880 Bagsvaerd

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG
Germany
Net EU contribution
€ 0,00
Address
Darmstädter Straße 34-36
64673 Zwingenberg

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Region
Darmstadt Bergstraße
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00