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Computational Design of Novel Functional Proteins for Immunoengineering

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Publications

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Author(s): Fabian Sesterhenn, Marie Galloux, Sabrina S. Vollers, Lucia Csepregi, Che Yang, Delphyne Descamps, Jaume Bonet, Simon Friedensohn, Pablo Gainza, Patricia Corthésy, Man Chen, Stéphane Rosset, Marie-Anne Rameix-Welti, Jean-François Éléouët, Sai T. Reddy, Barney S. Graham, Sabine Riffault, Bruno E. Correia
Published in: PLOS Biology, Issue 17/2, 2019, Page(s) e3000164, ISSN 1545-7885
DOI: 10.1371/journal.pbio.3000164

Rosetta FunFolDes – A general framework for the computational design of functional proteins

Author(s): Jaume Bonet, Sarah Wehrle, Karen Schriever, Che Yang, Anne Billet, Fabian Sesterhenn, Andreas Scheck, Freyr Sverrisson, Barbora Veselkova, Sabrina Vollers, Roxanne Lourman, Mélanie Villard, Stéphane Rosset, Thomas Krey, Bruno E. Correia
Published in: PLOS Computational Biology, Issue 14/11, 2018, Page(s) e1006623, ISSN 1553-7358
DOI: 10.1371/journal.pcbi.1006623

rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics

Author(s): Jaume Bonet, Zander Harteveld, Fabian Sesterhenn, Andreas Scheck, Bruno E. Correia
Published in: BMC Bioinformatics, Issue 20/1, 2019, ISSN 1471-2105
DOI: 10.1186/s12859-019-2796-3

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

Author(s): P. Gainza, F. Sverrisson, F. Monti, E. Rodolà, D. Boscaini, M. M. Bronstein, B. E. Correia
Published in: Nature Methods, Issue 2019, 2019, ISSN 1548-7091
DOI: 10.1038/s41592-019-0666-6

Trivalent cocktail of de novo designed immunogens enables the robust induction and focusing of functional antibodies in vivo

Author(s): F Sesterhenn, C Yang, JT Cramer, J Bonet, X Wen, LA Abriata, I Kucharska, CI Chiang, Y Wang, G Castoro, SS Vollers, M Galloux, CA Richard, S Rosset, P Corthésy, S Georgeon, M Villard, D Descamps, T Delgado, MA Rameix-Welti, V Más, S Ervin, JF Eléouët, S Riffault, JT Bates, JP Julien, Y Li, T Jardetzky, T Krey, BE Correia
Published in: Bioarxiv, Issue 2019, 2019
DOI: 10.1101/685867