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THE ROLE OF MUCINS AND MUCUS IN THE DISEASES CYSTIC FIBROSIS, CELIAC DISEASE, AND ULCERATIVE COLITIS

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Publications

Association between Brachyspira and irritable bowel syndrome with diarrhoea

Author(s): Karolina S Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simren, Gunnar C Hansson
Published in: Gut, 2020, Page(s) gutjnl-2020-321466, ISSN 0017-5749
DOI: 10.1136/gutjnl-2020-321466

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin

Author(s): Dalia Fakih, Ana M. Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M. Evans, Anna Ermund, Gunnar C. Hansson
Published in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Issue 318/6, 2020, Page(s) L1270-L1279, ISSN 1040-0605
DOI: 10.1152/ajplung.00485.2019

Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps

Author(s): Liisa Arike, Gunnar C. Hansson, Christian V. Recktenwald
Published in: Analytical Biochemistry, Issue 597, 2020, Page(s) 113668, ISSN 0003-2697
DOI: 10.1016/j.ab.2020.113668

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Author(s): Bjoern O. Schroeder, George M.H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E.V. Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Published in: Cell Host & Microbe, Issue 23/1, 2018, Page(s) 27-40.e7, ISSN 1931-3128
DOI: 10.1016/j.chom.2017.11.004

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

Author(s): Frida Svensson, Tiange Lang, Malin E. V. Johansson, Gunnar C. Hansson
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-35499-w

Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

Author(s): George Birchenough, Bjoern O. Schroeder, Fredrik Bäckhed, Gunnar C. Hansson
Published in: Gut Microbes, 2018, Page(s) 1-5, ISSN 1949-0976
DOI: 10.1080/19490976.2018.1513765

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

Author(s): Anna Ermund, Lauren N. Meiss, Brendan Dolan, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson
Published in: European Respiratory Journal, Issue 52/2, 2018, Page(s) 1800457, ISSN 0903-1936
DOI: 10.1183/13993003.00457-2018

"Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB"

Author(s): Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,1 Barbara Potempa, Bjorn Rabe, Marit Stirnberg, Ralph Lucius,Jorg W. Bartsch,Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John,Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey,and Christoph Becker-Pauly
Published in: CELL Reports, Issue 21, 2017, Page(s) 2090-2103, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.10.087

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Author(s): Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson
Published in: Gut, 2019, Page(s) gutjnl-2018-317571, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-317571

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Author(s): Joan Antoni Fernández-Blanco, Dalia Fakih, Liisa Arike, Ana M. Rodríguez-Piñeiro, Beatriz Martínez-Abad, Elin Skansebo, Sonya Jackson, James Root, Dave Singh, Christopher McCrae, Christopher M. Evans, Annika Åstrand, Anna Ermund, Gunnar C. Hansson
Published in: JCI Insight, Issue 3/17, 2018, ISSN 2379-3708
DOI: 10.1172/jci.insight.120994

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Author(s): Markus Furter, Mikael E. Sellin, Gunnar C. Hansson, Wolf-Dietrich Hardt
Published in: Cell Reports, Issue 27/9, 2019, Page(s) 2665-2678.e3, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.04.106

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Author(s): Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad
Published in: Nature, Issue 572/7770, 2019, Page(s) 474-480, ISSN 0028-0836
DOI: 10.1038/s41586-019-1443-5

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Author(s): Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
DOI: 10.3389/fphys.2019.00694

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

Author(s): Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez-Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Published in: Biochemical Journal, Issue 476/16, 2019, Page(s) 2281-2295, ISSN 0264-6021
DOI: 10.1042/bcj20190180

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Author(s): Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough
Published in: The Journal of Experimental Medicine, 2019, Page(s) jem.20190679, ISSN 0022-1007
DOI: 10.1084/jem.20190679

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

Author(s): Liisa Arike, Andrus Seiman, Sjoerd van der Post, Ana M. Rodriguez Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E.V. Johansson, Gunnar C. Hansson
Published in: Cell Reports, Issue 30/4, 2020, Page(s) 1077-1087.e3, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.12.068

Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

Author(s): Bjoern O. Schroeder, George M.H. Birchenough, Meenakshi Pradhan, Elisabeth E.L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Published in: Journal of Biological Chemistry, Issue 295/46, 2020, Page(s) 15712-15726, ISSN 0021-9258
DOI: 10.1074/jbc.ra120.015771

Membrane mucins of the intestine at a glance

Author(s): Thaher Pelaseyed, Gunnar C. Hansson
Published in: Journal of Cell Science, Issue 133/5, 2020, Page(s) jcs240929, ISSN 0021-9533
DOI: 10.1242/jcs.240929

Mucus and mucins in diseases of the intestinal and respiratory tracts

Author(s): G. C. Hansson
Published in: Journal of Internal Medicine, Issue 285/5, 2019, Page(s) 479-490, ISSN 0954-6820
DOI: 10.1111/joim.12910