THE ROLE OF MUCINS AND MUCUS IN THE DISEASES CYSTIC FIBROSIS, CELIAC DISEASE, AND ULCERATIVE COLITIS

Project Information

MUC2GO

Grant agreement ID: 694181

DOI 10.3030/694181

Project closed

EC signature date 5 August 2016

Start date 1 September 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

GOETEBORGS UNIVERSITET
Sweden

Publications

Peer reviewed articles (22)

Association between Brachyspira and irritable bowel syndrome with diarrhoea

Author(s): Karolina S Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simren, Gunnar C Hansson
Published in: Gut, 2020, Page(s) gutjnl-2020-321466, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321466

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin

Author(s): Dalia Fakih, Ana M. Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M. Evans, Anna Ermund, Gunnar C. Hansson
Published in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Issue 318/6, 2020, Page(s) L1270-L1279, ISSN 1040-0605
Publisher: American Physiological Society
DOI: 10.1152/ajplung.00485.2019

Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps

Author(s): Liisa Arike, Gunnar C. Hansson, Christian V. Recktenwald
Published in: Analytical Biochemistry, Issue 597, 2020, Page(s) 113668, ISSN 0003-2697
Publisher: Academic Press
DOI: 10.1016/j.ab.2020.113668

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

Author(s): Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V. Recktenwald, Ana M. Rodriguez-Pineiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E.V. Johansson
Published in: Journal of Biological Chemistry, Issue 297/1, 2021, Page(s) 100871, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100871

A single sulfatase is required to access colonic mucin by a gut bacterium

Author(s): Ana S. Luis, Chunsheng Jin, Gabriel Vasconcelos Pereira, Robert W. P. Glowacki, Sadie R. Gugel, Shaleni Singh, Dominic P. Byrne, Nicholas A. Pudlo, James A. London, Arnaud Baslé, Mark Reihill, Stefan Oscarson, Patrick A. Eyers, Mirjam Czjzek, Gurvan Michel, Tristan Barbeyron, Edwin A. Yates, Gunnar C. Hansson, Niclas G. Karlsson, Alan Cartmell, Eric C. Martens
Published in: Nature, Issue 598/7880, 2021, Page(s) 332-337, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03967-5

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Author(s): Bjoern O. Schroeder, George M.H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E.V. Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Published in: Cell Host & Microbe, Issue 23/1, 2018, Page(s) 27-40.e7, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2017.11.004

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

Author(s): Frida Svensson, Tiange Lang, Malin E. V. Johansson, Gunnar C. Hansson
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-35499-w

Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

Author(s): George Birchenough, Bjoern O. Schroeder, Fredrik Bäckhed, Gunnar C. Hansson
Published in: Gut Microbes, 2018, Page(s) 1-5, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2018.1513765

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

Author(s): Anna Ermund, Lauren N. Meiss, Brendan Dolan, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson
Published in: European Respiratory Journal, Issue 52/2, 2018, Page(s) 1800457, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.00457-2018

"Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB"

Author(s): Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,1 Barbara Potempa, Bjorn Rabe, Marit Stirnberg, Ralph Lucius,Jorg W. Bartsch,Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John,Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey,and Christoph Becker-Pauly
Published in: CELL Reports, Issue 21, 2017, Page(s) 2090-2103, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.10.087

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Author(s): Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson
Published in: Gut, 2019, Page(s) gutjnl-2018-317571, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317571

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Author(s): Joan Antoni Fernández-Blanco, Dalia Fakih, Liisa Arike, Ana M. Rodríguez-Piñeiro, Beatriz Martínez-Abad, Elin Skansebo, Sonya Jackson, James Root, Dave Singh, Christopher McCrae, Christopher M. Evans, Annika Åstrand, Anna Ermund, Gunnar C. Hansson
Published in: JCI Insight, Issue 3/17, 2018, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.120994

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Author(s): Markus Furter, Mikael E. Sellin, Gunnar C. Hansson, Wolf-Dietrich Hardt
Published in: Cell Reports, Issue 27/9, 2019, Page(s) 2665-2678.e3, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.04.106

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Author(s): Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad
Published in: Nature, Issue 572/7770, 2019, Page(s) 474-480, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1443-5

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Author(s): Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00694

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

Author(s): Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez-Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Published in: Biochemical Journal, Issue 476/16, 2019, Page(s) 2281-2295, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190180

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Author(s): Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough
Published in: The Journal of Experimental Medicine, 2019, Page(s) jem.20190679, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20190679

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

Author(s): Liisa Arike, Andrus Seiman, Sjoerd van der Post, Ana M. Rodriguez Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E.V. Johansson, Gunnar C. Hansson
Published in: Cell Reports, Issue 30/4, 2020, Page(s) 1077-1087.e3, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.068

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Author(s): Elisabeth E. L. Nyström, Beatriz Martinez-Abad, Liisa Arike, George M. H. Birchenough, Eric B. Nonnecke, Patricia A. Castillo, Frida Svensson, Charles L. Bevins, Gunnar C. Hansson, Malin E. V. Johansson
Published in: Science, Issue 372/6539, 2021, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb1590

Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

Author(s): Bjoern O. Schroeder, George M.H. Birchenough, Meenakshi Pradhan, Elisabeth E.L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Published in: Journal of Biological Chemistry, Issue 295/46, 2020, Page(s) 15712-15726, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015771

Membrane mucins of the intestine at a glance

Author(s): Thaher Pelaseyed, Gunnar C. Hansson
Published in: Journal of Cell Science, Issue 133/5, 2020, Page(s) jcs240929, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.240929

Mucus and mucins in diseases of the intestinal and respiratory tracts

Author(s): G. C. Hansson
Published in: Journal of Internal Medicine, Issue 285/5, 2019, Page(s) 479-490, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12910

Intellectual Property Rights

Patent (3)

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Application/Publication number: US Patent Office 10,035,821 B2
Date: 2016-10-21

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Application/Publication number: US Patent Office 10,035,821 B2
Date: 2016-10-21

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Application/Publication number: US Patent Office 10,035,821 B2
Date: 2016-10-21