THE ROLE OF MUCINS AND MUCUS IN THE DISEASES CYSTIC FIBROSIS, CELIAC DISEASE, AND ULCERATIVE COLITIS

Publications

Association between Brachyspira and irritable bowel syndrome with diarrhoea

Auteurs: Karolina S Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simren, Gunnar C Hansson
Publié dans: Gut, 2020, Page(s) gutjnl-2020-321466, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321466

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin

Auteurs: Dalia Fakih, Ana M. Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M. Evans, Anna Ermund, Gunnar C. Hansson
Publié dans: American Journal of Physiology-Lung Cellular and Molecular Physiology, Numéro 318/6, 2020, Page(s) L1270-L1279, ISSN 1040-0605
Éditeur: American Physiological Society
DOI: 10.1152/ajplung.00485.2019

Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps

Auteurs: Liisa Arike, Gunnar C. Hansson, Christian V. Recktenwald
Publié dans: Analytical Biochemistry, Numéro 597, 2020, Page(s) 113668, ISSN 0003-2697
Éditeur: Academic Press
DOI: 10.1016/j.ab.2020.113668

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

Auteurs: Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V. Recktenwald, Ana M. Rodriguez-Pineiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E.V. Johansson
Publié dans: Journal of Biological Chemistry, Numéro 297/1, 2021, Page(s) 100871, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100871

A single sulfatase is required to access colonic mucin by a gut bacterium

Auteurs: Ana S. Luis, Chunsheng Jin, Gabriel Vasconcelos Pereira, Robert W. P. Glowacki, Sadie R. Gugel, Shaleni Singh, Dominic P. Byrne, Nicholas A. Pudlo, James A. London, Arnaud Baslé, Mark Reihill, Stefan Oscarson, Patrick A. Eyers, Mirjam Czjzek, Gurvan Michel, Tristan Barbeyron, Edwin A. Yates, Gunnar C. Hansson, Niclas G. Karlsson, Alan Cartmell, Eric C. Martens
Publié dans: Nature, Numéro 598/7880, 2021, Page(s) 332-337, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-021-03967-5

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Auteurs: Bjoern O. Schroeder, George M.H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E.V. Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Publié dans: Cell Host & Microbe, Numéro 23/1, 2018, Page(s) 27-40.e7, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2017.11.004

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

Auteurs: Frida Svensson, Tiange Lang, Malin E. V. Johansson, Gunnar C. Hansson
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-35499-w

Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

Auteurs: George Birchenough, Bjoern O. Schroeder, Fredrik Bäckhed, Gunnar C. Hansson
Publié dans: Gut Microbes, 2018, Page(s) 1-5, ISSN 1949-0976
Éditeur: Landes Bioscience
DOI: 10.1080/19490976.2018.1513765

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

Auteurs: Anna Ermund, Lauren N. Meiss, Brendan Dolan, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson
Publié dans: European Respiratory Journal, Numéro 52/2, 2018, Page(s) 1800457, ISSN 0903-1936
Éditeur: European Respiratory Society
DOI: 10.1183/13993003.00457-2018

"Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB"

Auteurs: Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,1 Barbara Potempa, Bjorn Rabe, Marit Stirnberg, Ralph Lucius,Jorg W. Bartsch,Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John,Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey,and Christoph Becker-Pauly
Publié dans: CELL Reports, Numéro 21, 2017, Page(s) 2090-2103, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.10.087

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Auteurs: Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson
Publié dans: Gut, 2019, Page(s) gutjnl-2018-317571, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317571

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Auteurs: Joan Antoni Fernández-Blanco, Dalia Fakih, Liisa Arike, Ana M. Rodríguez-Piñeiro, Beatriz Martínez-Abad, Elin Skansebo, Sonya Jackson, James Root, Dave Singh, Christopher McCrae, Christopher M. Evans, Annika Åstrand, Anna Ermund, Gunnar C. Hansson
Publié dans: JCI Insight, Numéro 3/17, 2018, ISSN 2379-3708
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.120994

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Auteurs: Markus Furter, Mikael E. Sellin, Gunnar C. Hansson, Wolf-Dietrich Hardt
Publié dans: Cell Reports, Numéro 27/9, 2019, Page(s) 2665-2678.e3, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.04.106

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Auteurs: Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad
Publié dans: Nature, Numéro 572/7770, 2019, Page(s) 474-480, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-019-1443-5

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Auteurs: Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00694

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

Auteurs: Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez-Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Publié dans: Biochemical Journal, Numéro 476/16, 2019, Page(s) 2281-2295, ISSN 0264-6021
Éditeur: Portland Press, Ltd.
DOI: 10.1042/bcj20190180

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Auteurs: Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough
Publié dans: The Journal of Experimental Medicine, 2019, Page(s) jem.20190679, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20190679

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

Auteurs: Liisa Arike, Andrus Seiman, Sjoerd van der Post, Ana M. Rodriguez Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E.V. Johansson, Gunnar C. Hansson
Publié dans: Cell Reports, Numéro 30/4, 2020, Page(s) 1077-1087.e3, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.12.068

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Auteurs: Elisabeth E. L. Nyström, Beatriz Martinez-Abad, Liisa Arike, George M. H. Birchenough, Eric B. Nonnecke, Patricia A. Castillo, Frida Svensson, Charles L. Bevins, Gunnar C. Hansson, Malin E. V. Johansson
Publié dans: Science, Numéro 372/6539, 2021, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.abb1590

Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

Auteurs: Bjoern O. Schroeder, George M.H. Birchenough, Meenakshi Pradhan, Elisabeth E.L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Publié dans: Journal of Biological Chemistry, Numéro 295/46, 2020, Page(s) 15712-15726, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015771

Membrane mucins of the intestine at a glance

Auteurs: Thaher Pelaseyed, Gunnar C. Hansson
Publié dans: Journal of Cell Science, Numéro 133/5, 2020, Page(s) jcs240929, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.240929

Mucus and mucins in diseases of the intestinal and respiratory tracts

Auteurs: G. C. Hansson
Publié dans: Journal of Internal Medicine, Numéro 285/5, 2019, Page(s) 479-490, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.12910

Droits de propriété intellectuelle

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Numéro de demande/publication: US Patent Office 10,035,821 B2
Date: 2016-10-21

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Numéro de demande/publication: US Patent Office 10,035,821 B2
Date: 2016-10-21

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Numéro de demande/publication: US Patent Office 10,035,821 B2
Date: 2016-10-21

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