THE ROLE OF MUCINS AND MUCUS IN THE DISEASES CYSTIC FIBROSIS, CELIAC DISEASE, AND ULCERATIVE COLITIS

Informazioni relative al progetto

MUC2GO

ID dell’accordo di sovvenzione: 694181

DOI

10.3030/694181

Progetto chiuso

Data della firma CE 5 Agosto 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

GOETEBORGS UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (22)

Association between Brachyspira and irritable bowel syndrome with diarrhoea

Autori: Karolina S Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simren, Gunnar C Hansson
Pubblicato in: Gut, 2020, Pagina/e gutjnl-2020-321466, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321466

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin

Autori: Dalia Fakih, Ana M. Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M. Evans, Anna Ermund, Gunnar C. Hansson
Pubblicato in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Numero 318/6, 2020, Pagina/e L1270-L1279, ISSN 1040-0605
Editore: American Physiological Society
DOI: 10.1152/ajplung.00485.2019

Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps

Autori: Liisa Arike, Gunnar C. Hansson, Christian V. Recktenwald
Pubblicato in: Analytical Biochemistry, Numero 597, 2020, Pagina/e 113668, ISSN 0003-2697
Editore: Academic Press
DOI: 10.1016/j.ab.2020.113668

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

Autori: Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V. Recktenwald, Ana M. Rodriguez-Pineiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E.V. Johansson
Pubblicato in: Journal of Biological Chemistry, Numero 297/1, 2021, Pagina/e 100871, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100871

A single sulfatase is required to access colonic mucin by a gut bacterium

Autori: Ana S. Luis, Chunsheng Jin, Gabriel Vasconcelos Pereira, Robert W. P. Glowacki, Sadie R. Gugel, Shaleni Singh, Dominic P. Byrne, Nicholas A. Pudlo, James A. London, Arnaud Baslé, Mark Reihill, Stefan Oscarson, Patrick A. Eyers, Mirjam Czjzek, Gurvan Michel, Tristan Barbeyron, Edwin A. Yates, Gunnar C. Hansson, Niclas G. Karlsson, Alan Cartmell, Eric C. Martens
Pubblicato in: Nature, Numero 598/7880, 2021, Pagina/e 332-337, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03967-5

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Autori: Bjoern O. Schroeder, George M.H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E.V. Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Pubblicato in: Cell Host & Microbe, Numero 23/1, 2018, Pagina/e 27-40.e7, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2017.11.004

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

Autori: Frida Svensson, Tiange Lang, Malin E. V. Johansson, Gunnar C. Hansson
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-35499-w

Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

Autori: George Birchenough, Bjoern O. Schroeder, Fredrik Bäckhed, Gunnar C. Hansson
Pubblicato in: Gut Microbes, 2018, Pagina/e 1-5, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2018.1513765

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

Autori: Anna Ermund, Lauren N. Meiss, Brendan Dolan, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson
Pubblicato in: European Respiratory Journal, Numero 52/2, 2018, Pagina/e 1800457, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.00457-2018

"Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB"

Autori: Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,1 Barbara Potempa, Bjorn Rabe, Marit Stirnberg, Ralph Lucius,Jorg W. Bartsch,Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John,Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey,and Christoph Becker-Pauly
Pubblicato in: CELL Reports, Numero 21, 2017, Pagina/e 2090-2103, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.10.087

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Autori: Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson
Pubblicato in: Gut, 2019, Pagina/e gutjnl-2018-317571, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317571

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Autori: Joan Antoni Fernández-Blanco, Dalia Fakih, Liisa Arike, Ana M. Rodríguez-Piñeiro, Beatriz Martínez-Abad, Elin Skansebo, Sonya Jackson, James Root, Dave Singh, Christopher McCrae, Christopher M. Evans, Annika Åstrand, Anna Ermund, Gunnar C. Hansson
Pubblicato in: JCI Insight, Numero 3/17, 2018, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.120994

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Autori: Markus Furter, Mikael E. Sellin, Gunnar C. Hansson, Wolf-Dietrich Hardt
Pubblicato in: Cell Reports, Numero 27/9, 2019, Pagina/e 2665-2678.e3, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.04.106

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Autori: Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad
Pubblicato in: Nature, Numero 572/7770, 2019, Pagina/e 474-480, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1443-5

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Autori: Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00694

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

Autori: Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez-Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Pubblicato in: Biochemical Journal, Numero 476/16, 2019, Pagina/e 2281-2295, ISSN 0264-6021
Editore: Portland Press, Ltd.
DOI: 10.1042/bcj20190180

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Autori: Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough
Pubblicato in: The Journal of Experimental Medicine, 2019, Pagina/e jem.20190679, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20190679

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

Autori: Liisa Arike, Andrus Seiman, Sjoerd van der Post, Ana M. Rodriguez Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E.V. Johansson, Gunnar C. Hansson
Pubblicato in: Cell Reports, Numero 30/4, 2020, Pagina/e 1077-1087.e3, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.12.068

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Autori: Elisabeth E. L. Nyström, Beatriz Martinez-Abad, Liisa Arike, George M. H. Birchenough, Eric B. Nonnecke, Patricia A. Castillo, Frida Svensson, Charles L. Bevins, Gunnar C. Hansson, Malin E. V. Johansson
Pubblicato in: Science, Numero 372/6539, 2021, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abb1590

Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

Autori: Bjoern O. Schroeder, George M.H. Birchenough, Meenakshi Pradhan, Elisabeth E.L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Pubblicato in: Journal of Biological Chemistry, Numero 295/46, 2020, Pagina/e 15712-15726, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015771

Membrane mucins of the intestine at a glance

Autori: Thaher Pelaseyed, Gunnar C. Hansson
Pubblicato in: Journal of Cell Science, Numero 133/5, 2020, Pagina/e jcs240929, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.240929

Mucus and mucins in diseases of the intestinal and respiratory tracts

Autori: G. C. Hansson
Pubblicato in: Journal of Internal Medicine, Numero 285/5, 2019, Pagina/e 479-490, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.12910

Diritti di proprietà intellettuale

Patent (1)

3. CALCIUM BINDING COMPOUNDS BASED ON GAMMACARBOXY GLUTAMATE

Numero candidatura/pubblicazione: US Patent Office 10,035,821 B2
Data: 2016-10-21
Candidato/i: GOETEBORGS UNIVERSITET