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A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies

Deliverables

Publications

Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production

Author(s): Michaela Oeller; Sandra Laner-Plamberger; Linda Krisch; Eva Rohde; Dirk Strunk; Katharina Schallmoser
Published in: International Journal of Molecular Sciences, 4, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105178

Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics

Author(s): Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Published in: Current Stem Cell Reports, 8, 2022, Page(s) 72-92, ISSN 2198-7866
Publisher: Springer International Publishing AG
DOI: 10.1007/s40778-022-00212-1

Heparin and Derivatives for Advanced Cell Therapies

Author(s): Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk.
Published in: Int. J. Mol. Sci., 2021, Page(s) 12041, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222112041

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

Author(s): Vivian Capilla-González , Vicente Herranz-Pérez , Rachel Sarabia-Estrada, Nadir Kadri and Guido Moll
Published in: Front. Cell. Neurosci., volume 16, 2022, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.932281

RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe—Why the European Union Should Invest More!

Author(s): Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk
Published in: Frontiers in Medicine, 739987, 2021, ISSN 2296-858x
Publisher: Frontiers Media
DOI: 10.3389/fmed.2021.739987

Adherence to minimal experimental requirements for defining extracellular vesicles and their functions

Author(s): Rodolphe Poupardin, Martin Wolf, Dirk Strunk
Published in: Advanced Drug Delivery Reviews, 176, 2021, Page(s) 113872, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.113872

Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles

Author(s): André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk
Published in: International Journal of Molecular Sciences, 22/8, 2021, Page(s) 3890, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083890

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Author(s): Guido Moll, James A Ankrum, Scott D Olson, Jan A Nolta
Published in: Stem Cells Translational Medicine, 2022, Page(s) 1-12, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/stcltm/szab005

Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration

Author(s): Patricia Ebner-Peking, Linda Krisch, Martin Wolf, Sarah Hochmann, Anna Hoog, Balázs Vári, Katharina Muigg, Rodolphe Poupardin, Cornelia Scharler, Sabine Schmidhuber, Elisabeth Russe, Harald Stachelscheid, Achim Schneeberger, Katharina Schallmoser, Dirk Strunk
Published in: Theranostics, 11/17, 2021, Page(s) 8430-8447, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.59661

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy

Author(s): Rusan Ali Catar, Maria Bartosova, Edyta Kawka, Lei Chen, Iva Marinovic, Conghui Zhang, Hongfan Zhao, Dashan Wu, Daniel Zickler, Honorata Stadnik, Marek Karczewski, Julian Kamhieh-Milz, Achim Jörres, Guido Moll, Claus Peter Schmitt and Janusz Witowski
Published in: Frontiers in Immunology, 821681, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.821681

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

Author(s): Heide-Marie Binder, Nicole Maeding, Martin Wolf, André Cronemberger Andrade, Balazs Vari, Linda Krisch, Fausto Gueths Gomes, Constantin Blöchl, Katharina Muigg, Rodolphe Pourpadin, Thomas Heuser, Astrid Obermayer, Patricia Peking, Christian G Huber, Katharina Schallmoser, Dirk Strunk
Published in: Cells, 2021, Page(s) 3321, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10123321

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling

Author(s): Rusan Catar, Guido Moll, Julian Kamhieh-Milz, Christian Luecht, Lei Chen, Hongfan Zhao, Lucas Ernst, Kevin Willy, Matthias Girndt, Roman Fiedler, Janusz Witowski, Henning Morawietz, Olle Ringdén, Duska Dragun, Kai-Uwe Eckardt, Ralf Schindler and Daniel Zickler
Published in: Frontiers in Immunology, 774052, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2021.774052

Synergy of human platelet-derived extracellular vesicles with secretome proteins promotes regenerative functions.

Author(s): Fausto Gueths Gomes, André Cronemberger Andrade, Martin Wolf, Sarah Hochmann, Linda Krisch, Nicole Maeding, Christof Regl, Rodolphe Poupardin, Patricia Ebner-Peking, Christian G Huber, Nicole Meisner-Kober, Katharina Schallmoser, Dirk Strunk.
Published in: Biomedicines, 2022, Page(s) 238, ISSN 2227-9059
Publisher: MPDI
DOI: 10.3390/biomedicines10020238

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines.

Author(s): Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S, Reinke P
Published in: Trends in Molecular Medicine, 25, 2019, Page(s) 149-163, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2018.12.006

Validation of novel multiplex technologies

Author(s): Levent Akyüz*, Andreas Wilhelm, Florian Butke, Park Su-Jin, Anja Kuckuck, Hans-Dieter Volk, Gerald Grütz
Published in: Advances in precision medicine, bi-annual, 2017, ISSN 2424-9106
Publisher: WHIOCE

PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial

Author(s): Lars Norgren, Norbert Weiss, Sigrid Nikol, Robert J. Hinchliffe, John C. Lantis, Manesh R. Patel, Holger Reinecke, Racheli Ofir, Yael Rosen, Dan Peres, Zami Aberman
Published in: European Journal of Vascular and Endovascular Surgery, 57/4, 2019, Page(s) 538-545, ISSN 1078-5884
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2018.11.008

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Author(s): Chotima Böttcher, Stephan Schlickeiser, Marjolein A. M. Sneeboer, Desiree Kunkel, Anniki Knop, Evdokia Paza, Pawel Fidzinski, Larissa Kraus, Gijsje J. L. Snijders, René S Kahn, Axel R Schulz, Henrik E Mei, Elly M. Hol, Britta Siegmund, Rainer Glauben, Eike J Spruth, Lot D de Witte, Josef Priller
Published in: Nature Neuroscience, 22/1, 2019, Page(s) 78-90, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0290-2

Circulating endothelial cells as biomarker for cardiovascular diseases

Author(s): Maura Farinacci, Thomas Krahn, Wilfried Dinh, Hans-Dieter Volk, Hans-Dirk Düngen, Josephine Wagner, Timo Konen, Oliver von Ahsen
Published in: Research and Practice in Thrombosis and Haemostasis, 3/1, 2019, Page(s) 49-58, ISSN 2475-0379
Publisher: Wiley
DOI: 10.1002/rth2.12158

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells

Author(s): Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin, Olle Ringdén
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.02685

Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Author(s): Guido Moll *, Martin J. Hoogduijn and James A. Ankrum
Published in: Frontiers in Immunology, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.00243

Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product

Author(s): Guido Moll, Norman Drzeniek, Julian Kamhieh‐Milz, Sven Geissler, Petra Reinke
Published in: British Journal of Haematology, 2020, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16389

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Author(s): Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.02474

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response

Author(s): Rusan Catar, Guido Moll, Isa Hosp, Michele Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski
Published in: Cells, 10/4, 2021, Page(s) 910, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10040910

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

Author(s): Norman M Drzeniek, Andrea Mazzocchi, Stephan Schlickeiser, Steven D Forsythe, Guido Moll, Sven Geißler, Petra Reinke, Manfred Gossen, Vijay S Gorantla, Hans-Dieter Volk, Shay Soker
Published in: Biofabrication, 13/4, 2021, Page(s) 045002, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ac0a32

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Author(s): Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.01091

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel

Author(s): Jayeeta Giri & Guido Moll
Published in: Current Stem Cell Reports, 2022, Page(s) 1-13, ISSN 2198-7866
Publisher: Springer International Publishing
DOI: 10.1007/s40778-022-00207-y