A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies

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Publicaciones

Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production

Autores: Michaela Oeller; Sandra Laner-Plamberger; Linda Krisch; Eva Rohde; Dirk Strunk; Katharina Schallmoser
Publicado en: International Journal of Molecular Sciences, Edición 4, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105178

Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics

Autores: Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Publicado en: Current Stem Cell Reports, Edición 8, 2022, Página(s) 72-92, ISSN 2198-7866
Editor: Springer International Publishing AG
DOI: 10.1007/s40778-022-00212-1

Heparin and Derivatives for Advanced Cell Therapies

Autores: Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk.
Publicado en: Int. J. Mol. Sci., 2021, Página(s) 12041, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222112041

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

Autores: Vivian Capilla-González , Vicente Herranz-Pérez , Rachel Sarabia-Estrada, Nadir Kadri and Guido Moll
Publicado en: Front. Cell. Neurosci., Edición volume 16, 2022, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.932281

RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe—Why the European Union Should Invest More!

Autores: Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk
Publicado en: Frontiers in Medicine, Edición 739987, 2021, ISSN 2296-858x
Editor: Frontiers Media
DOI: 10.3389/fmed.2021.739987

Adherence to minimal experimental requirements for defining extracellular vesicles and their functions

Autores: Rodolphe Poupardin, Martin Wolf, Dirk Strunk
Publicado en: Advanced Drug Delivery Reviews, Edición 176, 2021, Página(s) 113872, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2021.113872

Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles

Autores: André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk
Publicado en: International Journal of Molecular Sciences, Edición 22/8, 2021, Página(s) 3890, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083890

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Autores: Guido Moll, James A Ankrum, Scott D Olson, Jan A Nolta
Publicado en: Stem Cells Translational Medicine, 2022, Página(s) 1-12, ISSN 2157-6564
Editor: AlphaMed Press
DOI: 10.1093/stcltm/szab005

Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration

Autores: Patricia Ebner-Peking, Linda Krisch, Martin Wolf, Sarah Hochmann, Anna Hoog, Balázs Vári, Katharina Muigg, Rodolphe Poupardin, Cornelia Scharler, Sabine Schmidhuber, Elisabeth Russe, Harald Stachelscheid, Achim Schneeberger, Katharina Schallmoser, Dirk Strunk
Publicado en: Theranostics, Edición 11/17, 2021, Página(s) 8430-8447, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.59661

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy

Autores: Rusan Ali Catar, Maria Bartosova, Edyta Kawka, Lei Chen, Iva Marinovic, Conghui Zhang, Hongfan Zhao, Dashan Wu, Daniel Zickler, Honorata Stadnik, Marek Karczewski, Julian Kamhieh-Milz, Achim Jörres, Guido Moll, Claus Peter Schmitt and Janusz Witowski
Publicado en: Frontiers in Immunology, Edición 821681, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.821681

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

Autores: Heide-Marie Binder, Nicole Maeding, Martin Wolf, André Cronemberger Andrade, Balazs Vari, Linda Krisch, Fausto Gueths Gomes, Constantin Blöchl, Katharina Muigg, Rodolphe Pourpadin, Thomas Heuser, Astrid Obermayer, Patricia Peking, Christian G Huber, Katharina Schallmoser, Dirk Strunk
Publicado en: Cells, 2021, Página(s) 3321, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10123321

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling

Autores: Rusan Catar, Guido Moll, Julian Kamhieh-Milz, Christian Luecht, Lei Chen, Hongfan Zhao, Lucas Ernst, Kevin Willy, Matthias Girndt, Roman Fiedler, Janusz Witowski, Henning Morawietz, Olle Ringdén, Duska Dragun, Kai-Uwe Eckardt, Ralf Schindler and Daniel Zickler
Publicado en: Frontiers in Immunology, Edición 774052, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.774052

Synergy of human platelet-derived extracellular vesicles with secretome proteins promotes regenerative functions.

Autores: Fausto Gueths Gomes, André Cronemberger Andrade, Martin Wolf, Sarah Hochmann, Linda Krisch, Nicole Maeding, Christof Regl, Rodolphe Poupardin, Patricia Ebner-Peking, Christian G Huber, Nicole Meisner-Kober, Katharina Schallmoser, Dirk Strunk.
Publicado en: Biomedicines, 2022, Página(s) 238, ISSN 2227-9059
Editor: MPDI
DOI: 10.3390/biomedicines10020238

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines.

Autores: Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S, Reinke P
Publicado en: Trends in Molecular Medicine, Edición 25, 2019, Página(s) 149-163, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2018.12.006

PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial

Autores: Lars Norgren, Norbert Weiss, Sigrid Nikol, Robert J. Hinchliffe, John C. Lantis, Manesh R. Patel, Holger Reinecke, Racheli Ofir, Yael Rosen, Dan Peres, Zami Aberman
Publicado en: European Journal of Vascular and Endovascular Surgery, Edición 57/4, 2019, Página(s) 538-545, ISSN 1078-5884
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2018.11.008

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Autores: Chotima Böttcher, Stephan Schlickeiser, Marjolein A. M. Sneeboer, Desiree Kunkel, Anniki Knop, Evdokia Paza, Pawel Fidzinski, Larissa Kraus, Gijsje J. L. Snijders, René S Kahn, Axel R Schulz, Henrik E Mei, Elly M. Hol, Britta Siegmund, Rainer Glauben, Eike J Spruth, Lot D de Witte, Josef Priller
Publicado en: Nature Neuroscience, Edición 22/1, 2019, Página(s) 78-90, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-018-0290-2

Circulating endothelial cells as biomarker for cardiovascular diseases

Autores: Maura Farinacci, Thomas Krahn, Wilfried Dinh, Hans-Dieter Volk, Hans-Dirk Düngen, Josephine Wagner, Timo Konen, Oliver von Ahsen
Publicado en: Research and Practice in Thrombosis and Haemostasis, Edición 3/1, 2019, Página(s) 49-58, ISSN 2475-0379
Editor: Wiley
DOI: 10.1002/rth2.12158

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells

Autores: Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin, Olle Ringdén
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2019.02685

Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Autores: Guido Moll *, Martin J. Hoogduijn and James A. Ankrum
Publicado en: Frontiers in Immunology, 2020, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2020.00243

Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product

Autores: Guido Moll, Norman Drzeniek, Julian Kamhieh‐Milz, Sven Geissler, Petra Reinke
Publicado en: British Journal of Haematology, 2020, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16389

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Autores: Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2019.02474

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response

Autores: Rusan Catar, Guido Moll, Isa Hosp, Michele Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski
Publicado en: Cells, Edición 10/4, 2021, Página(s) 910, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10040910

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

Autores: Norman M Drzeniek, Andrea Mazzocchi, Stephan Schlickeiser, Steven D Forsythe, Guido Moll, Sven Geißler, Petra Reinke, Manfred Gossen, Vijay S Gorantla, Hans-Dieter Volk, Shay Soker
Publicado en: Biofabrication, Edición 13/4, 2021, Página(s) 045002, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/ac0a32

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Autores: Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2020.01091

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel

Autores: Jayeeta Giri & Guido Moll
Publicado en: Current Stem Cell Reports, 2022, Página(s) 1-13, ISSN 2198-7866
Editor: Springer International Publishing
DOI: 10.1007/s40778-022-00207-y

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