A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies

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Pubblicazioni

Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production

Autori: Michaela Oeller; Sandra Laner-Plamberger; Linda Krisch; Eva Rohde; Dirk Strunk; Katharina Schallmoser
Pubblicato in: International Journal of Molecular Sciences, Numero 4, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105178

Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics

Autori: Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Pubblicato in: Current Stem Cell Reports, Numero 8, 2022, Pagina/e 72-92, ISSN 2198-7866
Editore: Springer International Publishing AG
DOI: 10.1007/s40778-022-00212-1

Heparin and Derivatives for Advanced Cell Therapies

Autori: Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk.
Pubblicato in: Int. J. Mol. Sci., 2021, Pagina/e 12041, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222112041

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

Autori: Vivian Capilla-González , Vicente Herranz-Pérez , Rachel Sarabia-Estrada, Nadir Kadri and Guido Moll
Pubblicato in: Front. Cell. Neurosci., Numero volume 16, 2022, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.932281

RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe—Why the European Union Should Invest More!

Autori: Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk
Pubblicato in: Frontiers in Medicine, Numero 739987, 2021, ISSN 2296-858x
Editore: Frontiers Media
DOI: 10.3389/fmed.2021.739987

Adherence to minimal experimental requirements for defining extracellular vesicles and their functions

Autori: Rodolphe Poupardin, Martin Wolf, Dirk Strunk
Pubblicato in: Advanced Drug Delivery Reviews, Numero 176, 2021, Pagina/e 113872, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.113872

Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles

Autori: André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk
Pubblicato in: International Journal of Molecular Sciences, Numero 22/8, 2021, Pagina/e 3890, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083890

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Autori: Guido Moll, James A Ankrum, Scott D Olson, Jan A Nolta
Pubblicato in: Stem Cells Translational Medicine, 2022, Pagina/e 1-12, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1093/stcltm/szab005

Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration

Autori: Patricia Ebner-Peking, Linda Krisch, Martin Wolf, Sarah Hochmann, Anna Hoog, Balázs Vári, Katharina Muigg, Rodolphe Poupardin, Cornelia Scharler, Sabine Schmidhuber, Elisabeth Russe, Harald Stachelscheid, Achim Schneeberger, Katharina Schallmoser, Dirk Strunk
Pubblicato in: Theranostics, Numero 11/17, 2021, Pagina/e 8430-8447, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.59661

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy

Autori: Rusan Ali Catar, Maria Bartosova, Edyta Kawka, Lei Chen, Iva Marinovic, Conghui Zhang, Hongfan Zhao, Dashan Wu, Daniel Zickler, Honorata Stadnik, Marek Karczewski, Julian Kamhieh-Milz, Achim Jörres, Guido Moll, Claus Peter Schmitt and Janusz Witowski
Pubblicato in: Frontiers in Immunology, Numero 821681, 2021, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2022.821681

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

Autori: Heide-Marie Binder, Nicole Maeding, Martin Wolf, André Cronemberger Andrade, Balazs Vari, Linda Krisch, Fausto Gueths Gomes, Constantin Blöchl, Katharina Muigg, Rodolphe Pourpadin, Thomas Heuser, Astrid Obermayer, Patricia Peking, Christian G Huber, Katharina Schallmoser, Dirk Strunk
Pubblicato in: Cells, 2021, Pagina/e 3321, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10123321

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling

Autori: Rusan Catar, Guido Moll, Julian Kamhieh-Milz, Christian Luecht, Lei Chen, Hongfan Zhao, Lucas Ernst, Kevin Willy, Matthias Girndt, Roman Fiedler, Janusz Witowski, Henning Morawietz, Olle Ringdén, Duska Dragun, Kai-Uwe Eckardt, Ralf Schindler and Daniel Zickler
Pubblicato in: Frontiers in Immunology, Numero 774052, 2021, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2021.774052

Synergy of human platelet-derived extracellular vesicles with secretome proteins promotes regenerative functions.

Autori: Fausto Gueths Gomes, André Cronemberger Andrade, Martin Wolf, Sarah Hochmann, Linda Krisch, Nicole Maeding, Christof Regl, Rodolphe Poupardin, Patricia Ebner-Peking, Christian G Huber, Nicole Meisner-Kober, Katharina Schallmoser, Dirk Strunk.
Pubblicato in: Biomedicines, 2022, Pagina/e 238, ISSN 2227-9059
Editore: MPDI
DOI: 10.3390/biomedicines10020238

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines.

Autori: Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S, Reinke P
Pubblicato in: Trends in Molecular Medicine, Numero 25, 2019, Pagina/e 149-163, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2018.12.006

PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial

Autori: Lars Norgren, Norbert Weiss, Sigrid Nikol, Robert J. Hinchliffe, John C. Lantis, Manesh R. Patel, Holger Reinecke, Racheli Ofir, Yael Rosen, Dan Peres, Zami Aberman
Pubblicato in: European Journal of Vascular and Endovascular Surgery, Numero 57/4, 2019, Pagina/e 538-545, ISSN 1078-5884
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2018.11.008

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Autori: Chotima Böttcher, Stephan Schlickeiser, Marjolein A. M. Sneeboer, Desiree Kunkel, Anniki Knop, Evdokia Paza, Pawel Fidzinski, Larissa Kraus, Gijsje J. L. Snijders, René S Kahn, Axel R Schulz, Henrik E Mei, Elly M. Hol, Britta Siegmund, Rainer Glauben, Eike J Spruth, Lot D de Witte, Josef Priller
Pubblicato in: Nature Neuroscience, Numero 22/1, 2019, Pagina/e 78-90, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-018-0290-2

Circulating endothelial cells as biomarker for cardiovascular diseases

Autori: Maura Farinacci, Thomas Krahn, Wilfried Dinh, Hans-Dieter Volk, Hans-Dirk Düngen, Josephine Wagner, Timo Konen, Oliver von Ahsen
Pubblicato in: Research and Practice in Thrombosis and Haemostasis, Numero 3/1, 2019, Pagina/e 49-58, ISSN 2475-0379
Editore: Wiley
DOI: 10.1002/rth2.12158

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells

Autori: Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin, Olle Ringdén
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2019.02685

Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Autori: Guido Moll *, Martin J. Hoogduijn and James A. Ankrum
Pubblicato in: Frontiers in Immunology, 2020, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2020.00243

Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product

Autori: Guido Moll, Norman Drzeniek, Julian Kamhieh‐Milz, Sven Geissler, Petra Reinke
Pubblicato in: British Journal of Haematology, 2020, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16389

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Autori: Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2019.02474

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response

Autori: Rusan Catar, Guido Moll, Isa Hosp, Michele Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski
Pubblicato in: Cells, Numero 10/4, 2021, Pagina/e 910, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10040910

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

Autori: Norman M Drzeniek, Andrea Mazzocchi, Stephan Schlickeiser, Steven D Forsythe, Guido Moll, Sven Geißler, Petra Reinke, Manfred Gossen, Vijay S Gorantla, Hans-Dieter Volk, Shay Soker
Pubblicato in: Biofabrication, Numero 13/4, 2021, Pagina/e 045002, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ac0a32

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Autori: Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2020.01091

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel

Autori: Jayeeta Giri & Guido Moll
Pubblicato in: Current Stem Cell Reports, 2022, Pagina/e 1-13, ISSN 2198-7866
Editore: Springer International Publishing
DOI: 10.1007/s40778-022-00207-y

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