FORMAT: a novel medium FOr Revolutionizing stem cell MAnufacturing Technologies

Projektinformationen

FORMAT

ID Finanzhilfevereinbarung: 692945

DOI 10.3030/692945

Projekt abgeschlossen

EK-Unterschriftsdatum 13 Dezember 2016

Startdatum 1 Januar 2017

Enddatum 30 Juni 2018

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 150 000,00

EU-Beitrag € 150 000,00

Koordiniert durch

WEIZMANN INSTITUTE OF SCIENCE
Israel

Ziel

One of the greatest challenges facing society is treating patients afflicted with degenerative and age-related disorders, such as multiple sclerosis, Parkinson’s disease and diabetes. For all of these, stem cell therapy represents a novel treatment approach and a great hope for the millions of patients worldwide. In my ERC-funded research project, we successfully managed to generate Extracellular-signal-Regulated Kinases (ERK) signalling independent human naïve Pluripotent Stem Cells (PSCs), a new category of human stem cells that retrain features that are characteristic of earlier developmental stages, i.e. they are more “primitive” than typical/conventional human PSCs. We managed to do so by employing a novel medium that allows the acquisition of many apparent naïve features that were previously observed only in rodent pluripotent stem cells. Importantly, this new pluripotent configuration, not only comes in different molecular flavours, but also has different functional properties. In turn, the first goal of our PoC project is to establish the technical feasibility of our novel medium by carrying out a series of molecular and functional tests. Such tests would enable us to further improve the existing medium conditions and create a commercial-like platform for enhanced expansion and derivation of human naïve induced PSCs. The second goal of FORMAT project is to establish the commercialization potential of our novel medium as a means to maintain standardized cells that can in turn be used to replenish, regenerate and repair damaged human tissues.

Wissenschaftliches Gebiet

• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › neurology › multiple sclerosis
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › basic medicine › neurology › parkinson

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-PoC-2015 - ERC Proof of Concept Grant

Aufforderung zur Vorschlagseinreichung

ERC-2015-PoC

Finanzierungsplan

ERC-POC - Proof of Concept Grant

Gastgebende Einrichtung

WEIZMANN INSTITUTE OF SCIENCE

• Netto-EU-Beitrag: € 150 000,00
• Adresse: HERZL STREET 234 ; 7610001 Rehovot ; Israel
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 150 000,00

Begünstigte (1)

WEIZMANN INSTITUTE OF SCIENCE

Israel

• Netto-EU-Beitrag: € 150 000,00
• Adresse: HERZL STREET 234 ; 7610001 Rehovot
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 150 000,00