Obiettivo One of the greatest challenges facing society is treating patients afflicted with degenerative and age-related disorders, such as multiple sclerosis, Parkinson’s disease and diabetes. For all of these, stem cell therapy represents a novel treatment approach and a great hope for the millions of patients worldwide. In my ERC-funded research project, we successfully managed to generate Extracellular-signal-Regulated Kinases (ERK) signalling independent human naïve Pluripotent Stem Cells (PSCs), a new category of human stem cells that retrain features that are characteristic of earlier developmental stages, i.e. they are more “primitive” than typical/conventional human PSCs. We managed to do so by employing a novel medium that allows the acquisition of many apparent naïve features that were previously observed only in rodent pluripotent stem cells. Importantly, this new pluripotent configuration, not only comes in different molecular flavours, but also has different functional properties. In turn, the first goal of our PoC project is to establish the technical feasibility of our novel medium by carrying out a series of molecular and functional tests. Such tests would enable us to further improve the existing medium conditions and create a commercial-like platform for enhanced expansion and derivation of human naïve induced PSCs. The second goal of FORMAT project is to establish the commercialization potential of our novel medium as a means to maintain standardized cells that can in turn be used to replenish, regenerate and repair damaged human tissues. Campo scientifico scienze mediche e della salutemedicina clinicaendocrinologiadiabetescienze mediche e della salutemedicina di baseneurologiasclerosi multiplascienze mediche e della salutebiotecnologia medicatecnologie cellularicellule staminaliscienze mediche e della salutemedicina di baseneurologiaparkinson Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-PoC-2015 - ERC Proof of Concept Grant Invito a presentare proposte ERC-2015-PoC Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-POC - Proof of Concept Grant Coordinatore WEIZMANN INSTITUTE OF SCIENCE Contribution nette de l'UE € 150 000,00 Indirizzo Herzl street 234 7610001 Rehovot Israele Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto WEIZMANN INSTITUTE OF SCIENCE Israele Contribution nette de l'UE € 150 000,00 Indirizzo Herzl street 234 7610001 Rehovot Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00
