Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer

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Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study

Author(s): Evert Jan Van Limbergen, Ann Hoeben, Relinde I.Y. Lieverse, Ruud Houben, Chantal Overhof, Alida Postma, Jaap Zindler, Frans Verhelst, Ludwig J. Dubois, Dirk De Ruysscher, Esther G.C. Troost, Philippe Lambin
Published in: International Journal of Radiation Oncology*Biology*Physics, Issue 109/5, 2021, Page(s) 1421-1430, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.053

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

Author(s): Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Published in: Journal for ImmunoTherapy of Cancer, Issue 9/3, 2021, Page(s) e001764, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2020-001764

A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy

Author(s): Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S. Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
Published in: Acta Oncologica, Issue 57/2, 2017, Page(s) 226-230, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1385842

18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) – A prospective externally validated study

Author(s): Sara Carvalho, Ralph T. H. Leijenaar, Esther G. C. Troost, Janna E. van Timmeren, Cary Oberije, Wouter van Elmpt, Lioe-Fee de Geus-Oei, Johan Bussink, Philippe Lambin
Published in: PLOS ONE, Issue 13/3, 2018, Page(s) e0192859, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0192859

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

Author(s): Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. Wiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Published in: Molecular Oncology, 2020, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12705

Will immunotherapy really change radiotherapy?

Author(s): Lambin, P., Lieverse, R., Baumann, M., Ebert, N.
Published in: The Lancet Oncology, Issue 20/12, 2019, Page(s) 1642-1644, ISSN 1470-2045
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30682-5

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Author(s): Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina,
Published in: BMC Cancer, Issue 20/1, 2020, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-020-07055-1

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Author(s): Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Published in: Seminars in Radiation Oncology, Issue 30/2, 2020, Page(s) 187-193, ISSN 1053-4296
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2019.12.003

Structural and functional radiomics for lung cancer

Author(s): G.Y. Wu, A. Jochems, T. Refaee, A. Ibrahim, C.G. Yan, S. Sanduleanu, H.C. Woodruff, P. Lambin
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2021, Page(s) 3961-3974, ISSN 1619-7089
Publisher: Springer Link
DOI: 10.1007/s00259-021-05242-1

Non-invasive imaging prediction of tumor hypoxia: A novel developed and externally validated CT and FDG-PET-based radiomic signatures

Author(s): Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Mathieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven, Rathan M. Subramiam, Shao Hui Huang, Brian O'Sullivan, Scott V. Bratman, Ludwig J. Dubois, Razvan L. Miclea, Dario Di Perri, Xavier Geets, Mireia Crispin-Ortuzar, Adi
Published in: Radiotherapy and Oncology, Issue 153, 2020, Page(s) 97-105, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2020.10.016

Automated detection and segmentation of non-small cell lung cancer computed tomography images

Author(s): S.P. Primakov, A. Ibrahim, J.E. van Timmeren, G.Y. Wu, S.A. Keek, M. Beuque, R.W.Y. Granzier, E. Lavrova, M. Scrivener, S. Sanduleanu, E. Kayan, I. Halilaj, Anouk Lenaers, J.L. Wu, R. Monshouwer, X. Geets, H.A. Gietema, L.E.L. Hendriks, O. Morin, A. Jochems, H.C. Woodruff, P. Lambin
Published in: Nature Communications, Issue 3423, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30841-3

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