Objective
Optoacoustic imaging is a highly scalable and versatile method that can be used for optical resolution microscopy (OR-OAM) at superficial depth yet can be adapted for tomographic imaging with ultrasonic resolution at centimeter penetration scale. However, the imaging speed of OR-OAM is slow as far as concerned with acquisition of volumetric data, which greatly restricts its usage in applications involving dynamic biological processes.
In this MSCA project, we propose to develop a new approach using multifocal structured illumination in conjunction with a spherical ultrasonic array detection to achieve real-time volumetric optoacoustic imaging in both optical and acoustic resolution modes. Several challenges are to be addressed to reach these objectives. Firstly, a multifocal structured illumination system with two identical beamsplitting gratings will be designed and fabricated. Secondly, optoacoustic signal unmixing method for the spherical ultrasonic array detection geometry will be developed and image reconstruction algorithms based on the unmixed signals devised. Thirdly, calibration methods for the proposed system will be investigated. Finally, real-time volumetric optoacoustic imaging will be demonstrated in living animals
With the proposed method, real-time volumetric imaging at multiple penetration scales can be accomplished, making it possible to study dynamic functional, kinetic and metabolism parameters at the cellular, organ and whole organism level. By opening new possibilities for visualization of multi-scale dynamics not attainable with existing imaging modalities, the new method will broadly affect both pre-clinical and clinical imaging in the fields of in vivo cell tracking, targeted molecular imaging, studies of tumor dynamics and neovascularization, functional brain imaging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- natural sciences mathematics pure mathematics geometry
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8006 Zurich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.