Objective
Most of phenotypic variation comes from variation in DNA sequence. However, a number of studies have clearly shown that phenotype variation and diversity can also be the result of epigenetic changes. The major goal of this proposal is to develop a novel methodology for robust production of epigenetically stable plant variants, in order to increase epigenetic and phenotypic diversity. A key element in the project will be a recent breakthrough in the generation of clonal individuals from different tissue types using inducible overexpression of the embryonic regulatory protein RKD4. Preliminary work shows that plants regenerated from roots inherit many aspects of root specific methylation and gene expression patterns, even in the leaf tissue. Importantly, these features are stably transmitted across generations. For this project, I propose to: (1) evaluate physiological consequences of altered epigenomes in RKD4 regenerated plants; (2) compare (epi)genomic and phenotypic variation between plants regenerated using hormones and RKD4 overexpression; (3) compare epigenomic and phenotypic consequences in regenerants of different Arabidopsis thaliana accessions and close A. thaliana relatives Arabidopsis lyrata and Capsella rubella. The program, which will be carried out under supervision of Detlef Weigel, a world leader in plant genetics and genomics, will substantially contribute to increasing the toolkit for plant breeders to generate meaningful phenotypic diversity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics epigenetics epigenomes
- natural sciences biological sciences microbiology bacteriology bacteriomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.