Objectif Heart failure (HF) is a progressing disease currently affecting 2% of the population in the developed world with a mortality rate of 50% within the first five years. While HF with reduced ejection fraction, primarily associated with myocardial infarction, can be detected with sufficient accuracy, HF with preserved ejection fraction is far more difficult to diagnose. Accordingly, there is an urgent need to better diagnose these patients to ultimately guide and improve treatment. Among the clinical imaging modalities, Cardiovascular Magnetic Resonance (CMR) is the gold standard for assessing cardiac mass and ejection fraction, and is capable to assess local cardiac mechanics and tissue properties. Beyond these established methods, cardiac diffusion tensor imaging has emerged as a new tool to enable insights into the microscopic morphology of the beating heart. Unfortunately, due to scan time limitations during clinical routine, compromises in spatial resolution and coverage have to be made. To overcome practical limitations of clinical in vivo CMR imaging and to enable prediction of disease progression for individual patients, additional tools are required. To this end, biomechanical models have attracted considerable attention. Once adapted sufficiently to in-vivo imaging, these models promise patient-specific insights into causes and progression of disease and, help guiding treatment. It is the objective of the present fellowship proposal to significantly advance patient-specific, image-guided modelling of HF by incorporating the most recent developments in both CMR imaging and biophysical modelling. The proposed framework will address limitations of current approaches, which impose generic assumptions about cardiac tissue properties and structure. With recent innovations in CMR imaging, as developed by the applicant, data on local changes of myocardial microstructure will be obtained to achieve the next level of diagnostic and predictive cardiac modelling of HF. Champ scientifique social sciencessociologydemographymortalitymedical and health sciencesclinical medicinecardiology Mots‑clés Heart failure with preserved ejection fraction Patient specific biomechanical models Model based heart failure prediction Advanced cardiovascular magnetic resonance Personalized treatment planning Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2016 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2016 Voir d’autres projets de cet appel Régime de financement MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinateur EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Contribution nette de l'UE € 247 840,20 Adresse Raemistrasse 101 8092 Zuerich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 247 840,20 Partenaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire Partenaire Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA États-Unis Contribution nette de l'UE € 0,00 Adresse FRANKLIN STREET 1111 12 FLOOR 94607 OAKLAND CA Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 160 130,40
