CORDIS
EU research results

CORDIS

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Understanding pathogen, livestock, environment interactions involving bluetongue virus

Project information

Grant agreement ID: 727393

Status

Ongoing project

  • Start date

    1 June 2017

  • End date

    30 November 2020

Funded under:

H2020-EU.3.2.1.1.

  • Overall budget:

    € 6 039 301,50

  • EU contribution

    € 6 039 301,50

Coordinated by:

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

Objective

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe.
Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies.
PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

Coordinator

THE UNIVERSITY OF NOTTINGHAM

Address

University Park
Ng7 2rd Nottingham

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 301 601,50

Participants (18)

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL

France

EU Contribution

€ 396 250

CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC

France

EU Contribution

€ 333 365

ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE G CAPORALE

Italy

EU Contribution

€ 393 875

FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT

Germany

EU Contribution

€ 290 000

ENVIRONMENTAL RESEARCH GROUP OXFORD LIMITED

United Kingdom

EU Contribution

€ 143 281,25

UNIVERSITE LIBRE DE BRUXELLES

Belgium

EU Contribution

€ 188 705

INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP

Spain

EU Contribution

€ 203 625

STICHTING WAGENINGEN RESEARCH

Netherlands

EU Contribution

€ 418 000

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 640 438,75

KIMRON VETERINARY INSTITUTE

Israel

EU Contribution

€ 87 500

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 172 625

STATENS VETERINAERMEDICINSKA ANSTALT

Sweden

EU Contribution

€ 230 000

KAFKAS UNIVERSITESI

Turkey

EU Contribution

€ 110 000

INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II

Morocco

EU Contribution

€ 137 500

THE PIRBRIGHT INSTITUTE LBG

United Kingdom

EU Contribution

€ 434 822,50

International Livestock Research Institute

Kenya

EU Contribution

€ 287 851,25

INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES

Senegal

EU Contribution

€ 129 861,25

INSTITUT PASTEUR DE TUNIS

Tunisia

EU Contribution

€ 140 000

Project information

Grant agreement ID: 727393

Status

Ongoing project

  • Start date

    1 June 2017

  • End date

    30 November 2020

Funded under:

H2020-EU.3.2.1.1.

  • Overall budget:

    € 6 039 301,50

  • EU contribution

    € 6 039 301,50

Coordinated by:

THE UNIVERSITY OF NOTTINGHAM

United Kingdom