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Armoring multifunctional T cells for cancer therapy

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High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

Author(s): Felicitas Rataj, Severin J. Jacobi, Stefan Stoiber, Florian Asang, Justyna Ogonek, Nicholas Tokarew, Bruno L. Cadilha, Erwin van Puijenbroek, Constanze Heise, Peter Duewell, Stefan Endres, Christian Klein, Sebastian Kobold
Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 79-87, ISSN 0007-0920
DOI: 10.1038/s41416-018-0341-1

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Author(s): Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-16838-w

Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives—a meeting report

Author(s): Catarina Pinto, Michael Bergmann, Daria Briukhovetska, Volkmar Nuessler, Mario Sznol, Michael von Bergwelt-Baildon, Sebastian Kobold
Published in: Journal for ImmunoTherapy of Cancer, Issue 8/1, 2019, Page(s) e000268, ISSN 2051-1426
DOI: 10.1136/jitc-2019-000268

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Author(s): Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426
DOI: 10.1186/s40425-019-0778-7

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Author(s): Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02632

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

Author(s): Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold
Published in: Translational Oncology, Issue 12/2, 2019, Page(s) 350-360, ISSN 1936-5233
DOI: 10.1016/j.tranon.2018.10.014

Innate and adaptive immunity combined for cancer treatment

Author(s): Sebastian Kobold
Published in: Proceedings of the National Academy of Sciences, Issue 116/4, 2019, Page(s) 1087-1088, ISSN 0027-8424
DOI: 10.1073/pnas.1820166116

Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth

Author(s): Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold
Published in: Proceedings of the National Academy of Sciences, Issue 114/49, 2017, Page(s) 12994-12999, ISSN 0027-8424
DOI: 10.1073/pnas.1705165114

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Author(s): Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Published in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1283, ISSN 1422-0067
DOI: 10.3390/ijms20061283

Targeting interleukin-22 for cancer therapy

Author(s): Anamarija Markota, Stefan Endres, Sebastian Kobold
Published in: Human Vaccines & Immunotherapeutics, Issue 14/8, 2018, Page(s) 2012-2015, ISSN 2164-5515
DOI: 10.1080/21645515.2018.1461300

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Author(s): Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01955

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

Author(s): Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Published in: Cells, Issue 8/5, 2019, Page(s) 472, ISSN 2073-4409
DOI: 10.3390/cells8050472

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Author(s): Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Published in: Clinical Cancer Research, Issue 25/19, 2019, Page(s) 5890-5900, ISSN 1078-0432
DOI: 10.1158/1078-0432.ccr-18-3927

Advances in cancer immunotherapy 2019 – latest trends

Author(s): Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner, Michael von Bergwelt-Baildon
Published in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966
DOI: 10.1186/s13046-019-1266-0

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Author(s): Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong
Published in: Science Advances, Issue 5/6, 2019, Page(s) eaav4275, ISSN 2375-2548
DOI: 10.1126/sciadv.aav4275

Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells

Author(s): Diana Darowski, Sebastian Kobold, Christian Jost, Christian Klein
Published in: mAbs, Issue 11/4, 2019, Page(s) 621-631, ISSN 1942-0870
DOI: 10.1080/19420862.2019.1596511

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

Author(s): Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
DOI: 10.3389/fonc.2018.00285

Teaching an old dog new tricks: next-generation CAR T cells

Author(s): Nicholas Tokarew, Justyna Ogonek, Stefan Endres, Michael von Bergwelt-Baildon, Sebastian Kobold
Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 26-37, ISSN 0007-0920
DOI: 10.1038/s41416-018-0325-1

Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy

Author(s): Stephan F. Kruger, Bruno L. Cadilha, Michael Bergwelt‐Baildon, Stefan Endres, Sebastian Kobold
Published in: Clinical Pharmacology & Therapeutics, Issue 107/1, 2019, Page(s) 47-49, ISSN 0009-9236
DOI: 10.1002/cpt.1659