CORDIS
EU research results

CORDIS

English EN
EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Objective

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITA DEGLI STUDI DI TORINO

Address

Via Giuseppe Verdi 8
10124 Torino

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 596 143,85

Participants (18)

Sort alphabetically

Sort by EU Contribution

Expand all

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 390 887,50

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 381 343,75

INSTITUT CURIE

France

EU Contribution

€ 408 885

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON

Spain

EU Contribution

€ 453 457,50

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

EU Contribution

€ 429 325

Masarykova univerzita

Czechia

EU Contribution

€ 473 250

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 433 497,50

BIOBANKS AND BIOMOLECULAR RESOURCESRESEARCH INFRASTRUCTURE CONSORTIUM(BBMRI-ERIC)

Austria

EU Contribution

€ 70 558,75

ROYAL COLLEGE OF SURGEONS IN IRELAND

Ireland

EU Contribution

€ 170 607,50

INSTITUT CATALA D'ONCOLOGIA

Spain

EU Contribution

€ 121 146,25

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 38 995

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 214 256,25

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 96 971,25

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italy

EU Contribution

€ 23 125

HOSPITAL UNIVERSITARIO DE FUENLABRADA

Spain

EU Contribution

€ 27 287,50

KAIROS3D SRL

Italy

EU Contribution

€ 213 375

OCELLO BV

Netherlands

EU Contribution

€ 231 152,50

SEEDING SCIENCE

France

EU Contribution

€ 381 933,65

Project information

Grant agreement ID: 731105

Status

Ongoing project

  • Start date

    1 February 2018

  • End date

    31 January 2022

Funded under:

H2020-EU.1.4.1.2.

  • Overall budget:

    € 5 156 198,75

  • EU contribution

    € 5 156 198,75

Coordinated by:

UNIVERSITA DEGLI STUDI DI TORINO

Italy