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EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Objective

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.

Call for proposal

H2020-INFRAIA-2017-1-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITA DEGLI STUDI DI TORINO
Address
Via Giuseppe Verdi 8
10124 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 596 143,85

Participants (18)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 403 387,50
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 251 133,63
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
INSTITUT CURIE
France
EU contribution
€ 421 385
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
EU contribution
€ 517 595
Address
Calle Nazaret 115-117
08035 Barcelona
Activity type
Research Organisations
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 429 325
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Masarykova univerzita
Czechia
EU contribution
€ 448 250
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 380 225,85
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)
Austria
EU contribution
€ 70 558,75
Address
Neue Stiftingtalstrasse 2/B/6
8010 Graz
Activity type
Research Organisations
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 200 374,70
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
INSTITUT CATALA D'ONCOLOGIA
Spain
EU contribution
€ 48 565,73
Address
Av Gran Via De L'hospitalet 199-203
08908 L'hospitalet Del Llobregat
Activity type
Research Organisations
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 51 250
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 214 256,25
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 96 971,25
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 211 693,13
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOSPITAL UNIVERSITARIO DE FUENLABRADA
Spain
EU contribution
€ 16 037,50
Address
Calle Del Molino 2
28942 Fuenlabrada
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
KAIROS3D SRL
Italy
EU contribution
€ 249 675
Address
Via Agostino Da Montefeltro 2
10134 Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OCELLO BV
Netherlands
EU contribution
€ 254 936,98
Address
J.h Oortweg 21
2333 CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SEEDING SCIENCE
France
EU contribution
€ 294 433,63
Address
19 Rue De La Mare
75020 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)