Objective
Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.
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Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
10124 Torino
Italy
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Participants (18)
3000 Leuven
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CB2 1TN Cambridge
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75231 Paris
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08035 Barcelona
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1066 CX Amsterdam
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601 77 Brno
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69117 Heidelberg
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8010 Graz
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2 Dublin
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08908 Hospitalet de Llobregat
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M13 9PL Manchester
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9713 GZ Groningen
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0450 Oslo
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20121 Milano
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28942 Fuenlabrada
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10134 Torino
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2333 CH LEIDEN
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75020 Paris
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.