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EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Objective

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.

Call for proposal

H2020-INFRAIA-2016-2017

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Sub call

H2020-INFRAIA-2017-1-two-stage

Coordinator

UNIVERSITA DEGLI STUDI DI TORINO
Net EU contribution
€ 596 143,85
Address
Via Giuseppe Verdi 8
10124 Torino
Italy

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (18)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 403 387,50
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 251 133,63
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 421 385,00
Address
Rue D'ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
Net EU contribution
€ 517 595,00
Address
Calle Nazaret 115-117
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
Net EU contribution
€ 429 325,00
Address
Plesmanlaan 121
1066 CX Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Masarykova univerzita
Czechia
Net EU contribution
€ 448 250,00
Address
Zerotinovo Namesti 9
601 77 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Net EU contribution
€ 380 225,85
Address
Meyerhofstrasse 1
69117 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)
Austria
Net EU contribution
€ 70 558,75
Address
Neue Stiftingtalstrasse 2/b/6
8010 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
Net EU contribution
€ 200 374,70
Address
St Stephen's Green 123
2 Dublin

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT CATALA D'ONCOLOGIA
Spain
Net EU contribution
€ 48 565,73
Address
Av Gran Via De L'hospitalet 199-203
08908 L'hospitalet Del Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 51 250,00
Address
Oxford Road
M13 9PL Manchester

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 214 256,25
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 96 971,25
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
Net EU contribution
€ 211 693,13
Address
Via Filodrammatici 10
20121 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
HOSPITAL UNIVERSITARIO DE FUENLABRADA
Spain
Net EU contribution
€ 16 037,50
Address
Calle Del Molino 2
28942 Fuenlabrada

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
KAIROS3D SRL
Italy
Net EU contribution
€ 249 675,00
Address
Via Agostino Da Montefeltro 2
10134 Torino

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Piemonte Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CROWN BIOSCIENCE NETHERLANDS BV
Netherlands
Net EU contribution
€ 254 936,98
Address
Yalelaan 42
3512 KC Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SEEDING SCIENCE
France
Net EU contribution
€ 294 433,63
Address
19 Rue De La Mare
75020 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00