EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Project Information

EDIReX

Grant agreement ID: 731105

DOI 10.3030/731105

Project closed

EC signature date 8 December 2017

Start date 1 February 2018

End date 31 July 2022

Funded under

• EXCELLENT SCIENCE - Research Infrastructures

Total cost € 5 156 198,75

EU contribution € 5 156 198,75

Coordinated by

UNIVERSITA DEGLI STUDI DI TORINO
Italy

Deliverables

Documents, reports (3)

Outline of the information recorded in a “PDX Passport”

This Deliverable relates to Task 2.2.1. All PDX models biobanked for the performance of WP3 and WP4 will be accompanied by a PDX Passport. This information sheet will summarise all relevant information on health status (WP2), as well as ethics (WP5) and minimal information on the model defined under WP1. An outline of the Passport will be drafted at the consensus meeting in M1-M2 and further optimised along the first 6 months of the project. This report will therefore outline the information agreed to be recorded in the PDX Passport.

Summary of the outcome of the two ethics workshops

This deliverable is related to Task 52 and will describe the discussions and outcome of the two ethics workshops organised at M18 and M36 of the project on the side of our GA meetings

Flyer describing the EurOPDX Infrastructure and available resources and services

This deliverable relates to Task 7.1.4. A flyer will be designed to include crucial information about the project, the partners involved, the services provided. Its content will remain general, in order to remain valid during the whole project duration, and provide all useful links to allow users to follow our activities through the website, Data Portal, and our Twitter account and LinkedIn group. The flyer will be available at M20, and its design and content described in this deliverable.

Publications

Peer reviewed articles (13)

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

Author(s): Zdenka Dudová; Nathalie Conte; Jeremy Mason; Dalibor Stuchlík; Radim Peša; Csaba Halmagyi; Zinaida Perova; Abayomi Mosaku; Ross Thorne; Alex Follette; Ľuboslav Pivarč; Radim Šašinka; Muhammad Usman; Steven Neuhauser; Dale A. Begley; Debra M. Krupke; Massimiliano Frassà; Alessandro Fiori; Riccardo Corsi; Luca Vezzadini; Claudio Isella; Andrea Bertotti; Carol Bult; Helen Parkinson; Enzo Medi
Published in: BMC Genomics, Issue 14712164, 2022, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-022-08367-1

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Author(s): Alice C O'Farrell 1 , Monika A Jarzabek 1 , Andreas U Lindner 2 , Steven Carberry 2 , Emer Conroy 3 , Ian S Miller 1 , Kate Connor 1 , Liam Shiels 1 , Eugenia R Zanella 4 5 , Federico Lucantoni 2 , Adam Lafferty 1 , Kieron White 1 , Mariangela Meyer Meyer Villamandos 2 , Patrick Dicker 6 , William M Gallagher 3 , Simon A Keek 7 , Sebastian Sanduleanu 7 , Philippe Lambin 7 8 ,
Published in: Cancers, Issue 2020, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.

Author(s): Ian S. Miller; Sonja Khan; Liam P. Shiels; Sudipto Das; Alice C. O' Farrell; Kate Connor; Adam Lafferty; Bruce Moran; Claudio Isella; Paul Loadman; Emer Conroy; Susan Cohrs; Roger Schibli; Robert S. Kerbel; William M. Gallagher; Elisabetta Marangoni; Kathleen Bennett; Darran P. O' Connor; Róisín M. Dwyer; Annette T. Byrne
Published in: Cancer Medicine, 2022, ISSN 2045-7634
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/cam4.4756

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Author(s): Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline
Published in: Nature Genetics, Issue 53/1, 2021, Page(s) 86-99, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00750-6

EGFR Blockade Reverts Resistance to KRAS G12C Inhibition in Colorectal Cancer

Author(s): Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino,
Published in: Cancer Discovery, Issue 10/8, 2020, Page(s) 1129-1139, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

Author(s): Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti
Published in: Database, Issue 2019, 2019, ISSN 1758-0463
Publisher: Oxford University Press
DOI: 10.1093/database/baz080

A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits.

Author(s): Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu
Published in: Cancer Research, 2019, Page(s) canres.1166.2019, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1166

Patient-derived xenografts (PDXs) as model systems for human cancer

Author(s): Federica Invrea, Roberta Rovito, Erica Torchiaro, Consalvo Petti, Claudio Isella, Enzo Medico
Published in: Current Opinion in Biotechnology, Issue 63, 2020, Page(s) 151-156, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2020.01.003

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

Author(s): Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12807-0

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Author(s): Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Published in: Science Translational Medicine, Issue 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

One tool to find them all: a case of data integration and querying in a distributed LIMS platform

Author(s): Alberto Grand, Emanuele Geda, Andrea Mignone, Andrea Bertotti, Alessandro Fiori
Published in: Database, Issue 2019, 2019, ISSN 1758-0463
Publisher: Oxford University Press
DOI: 10.1093/database/baz004

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Author(s): Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Published in: Breast Cancer Research, Issue 21/1, 2019, ISSN 1465-542X
Publisher: Springer Nature
DOI: 10.1186/s13058-019-1220-2

Melanoma models for the next generation of therapies

Author(s): E. Elizabeth Patton, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Ping Chi, Meenhard Herlyn, Sheri L. Holmen, Florian A. Karreth, Charles K. Kaufman, Shaheen Khan, Sebastian Kobold, Eleonora Leucci, Carmit Levy, David B. Lombard, Amanda W. Lund, Kerrie L. Marie, Jean-Christophe Marine, Richard Marais, Martin McM
Published in: Cancer Cell, 2021, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

Other (2)

EurOPDX IT tools to support cancer research with patient-derived xenograft models

Author(s): Enzo Medico, Emilie Vinolo
Published in: Webinar, 2020
Publisher: EMBL-EBI
DOI: 10.6019/tol.europdxtools-w.2020.00001.1

EurOPDX Data Portal: a repository of patient-derived xenograft models

Author(s): Enzo Medico, Emilie Vinolo
Published in: Webinar, 2019
Publisher: EMBL-EBI
DOI: 10.6019/tol.europdx-w.2019.00001.1

Conference proceedings (3)

The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Author(s): E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo.
Published in: AACR Annual Meeting 2018 Online Proceedings, 2018
Publisher: American Association for Cancer Research

The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models

Author(s): E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre
Published in: European Journal of Cancer, Issue Volume 103S1, November 2018, 2018, Page(s) 118, ISSN 0959-8049
Publisher: Elsevier

Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development

Author(s): Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price
Published in: AACR Annual Meeting 2019 Online Proceedings, 2019
Publisher: American Association for Cancer Research