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EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Deliverables

Outline of the information recorded in a “PDX Passport”

This Deliverable relates to Task 2.2.1. All PDX models biobanked for the performance of WP3 and WP4 will be accompanied by a PDX Passport. This information sheet will summarise all relevant information on health status (WP2), as well as ethics (WP5) and minimal information on the model defined under WP1. An outline of the Passport will be drafted at the consensus meeting in M1-M2 and further optimised along the first 6 months of the project. This report will therefore outline the information agreed to be recorded in the PDX Passport.

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Publications

The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Author(s): E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo.
Published in: AACR Annual Meeting 2018 Online Proceedings, 2018

The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models

Author(s): E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre
Published in: European Journal of Cancer, Issue Volume 103S1, November 2018, 2018, Page(s) 118, ISSN 0959-8049

Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development

Author(s): Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price
Published in: AACR Annual Meeting 2019 Online Proceedings, 2019

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

Author(s): Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti
Published in: Database, Issue 2019, 2019, ISSN 1758-0463
DOI: 10.1093/database/baz080

A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits.

Author(s): Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu
Published in: Cancer Research, 2019, Page(s) canres.1166.2019, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-19-1166

Patient-derived xenografts (PDXs) as model systems for human cancer

Author(s): Federica Invrea, Roberta Rovito, Erica Torchiaro, Consalvo Petti, Claudio Isella, Enzo Medico
Published in: Current Opinion in Biotechnology, Issue 63, 2020, Page(s) 151-156, ISSN 0958-1669
DOI: 10.1016/j.copbio.2020.01.003

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

Author(s): Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-12807-0

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Author(s): Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Published in: Science Translational Medicine, Issue 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aax8313

EurOPDX Data Portal: a repository of patient-derived xenograft models

Author(s): Enzo Medico, Emilie Vinolo
Published in: Webinar, 2019
DOI: 10.6019/tol.europdx-w.2019.00001.1