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An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes

Deliverables

Software for detection of pathway co-enrichment for extracting of patient(group)-specific pathways also enriched in target sites of effective drugs

Software for detection of pathway co-enrichment for extracting of patient(group)-specific pathways also enriched in target sites of effective drugs

Diseasome 2.0 network

Diseasome 2.0 network

Searching for OpenAIRE data...

Publications

Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease

Author(s): Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Martin Deile, Pavel I. Nedvetsky, Andreas Güldner, César Ibarra-Alvarado, Axel Gödecke, Harald H. H. W. Schmidt
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-66639-w

On the Clinical Pharmacology of Reactive Oxygen Species

Author(s): Ana I. Casas, Cristian Nogales, Hermann A. M. Mucke, Alexandra Petraina, Antonio Cuadrado, Ana I. Rojo, Pietro Ghezzi, Vincent Jaquet, Fiona Augsburger, Francois Dufrasne, Jalal Soubhye, Soni Deshwal, Moises Di Sante, Nina Kaludercic, Fabio Di Lisa, Harald H. H. W. Schmidt
Published in: Pharmacological Reviews, Issue 72/4, 2020, Page(s) 801-828, ISSN 0031-6997
DOI: 10.1124/pr.120.019422

De Novo and Supervised Endophenotyping Using Network-Guided Ensemble Learning

Author(s): Simon J. Larsen, Harald H.H.W. Schmidt, Jan Baumbach
Published in: Systems Medicine, Issue 3/1, 2020, Page(s) 8-21, ISSN 2573-3370
DOI: 10.1089/sysm.2019.0008

netDx: Software for building interpretable patient classifiers by multi-'omic data integration using patient similarity networks

Author(s): Shraddha Pai, Philipp Weber, Ruth Isserlin, Hussam Kaka, Shirley Hui, Muhammad Ahmad Shah, Luca Giudice, Rosalba Giugno, Anne Krogh Nøhr, Jan Baumbach, Gary D. Bader
Published in: F1000Research, Issue 9, 2020, Page(s) 1239, ISSN 2046-1402
DOI: 10.12688/f1000research.26429.2

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

Author(s): Mahmoud H. Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A. Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M. H. Schiffers, Ger M. Janssen, Pamela W. M. Kleikers, Anil Wipat, Jan Baumbach, Jo G. R. De Mey, Harald H. H. W. Schmidt
Published in: PLOS Biology, Issue 18/11, 2020, Page(s) e3000885, ISSN 1545-7885
DOI: 10.1371/journal.pbio.3000885

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Author(s): Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling, Jan Baumbach
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-17189-2

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Author(s): Blandine Comte, Jan Baumbach, Arriel Benis, José Basílio, Nataša Debeljak, Åsmund Flobak, Christian Franken, Nissim Harel, Feng He, Martin Kuiper, Juan Albino Méndez Pérez, Estelle Pujos-Guillot, Tadeja Režen, Damjana Rozman, Johannes A. Schmid, Jeanesse Scerri, Paolo Tieri, Kristel Van Steen, Sona Vasudevan, Steven Watterson, Harald H.H.W. Schmidt
Published in: Network and Systems Medicine, Issue 3/1, 2020, Page(s) 67-90, ISSN 2690-5949
DOI: 10.1089/nsm.2020.0004

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Author(s): Ana I. Casas, Pamela W.M. Kleikers, Eva Geuss, Friederike Langhauser, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Martin Hrabê de Angelis, Javier Egea, Manuela G. Lopez, Christoph Kleinschnitz, Harald H.H.W. Schmidt
Published in: Journal of Clinical Investigation, Issue 129/4, 2019, Page(s) 1772-1778, ISSN 0021-9738
DOI: 10.1172/jci124283

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage

Author(s): Mahmoud H. Elbatreek, Mayra P. Pachado, Antonio Cuadrado, Karin Jandeleit-Dahm, Harald H.H.W. Schmidt
Published in: Trends in Endocrinology & Metabolism, Issue 30/5, 2019, Page(s) 312-327, ISSN 1043-2760
DOI: 10.1016/j.tem.2019.02.006

E. coli gene regulatory networks are inconsistent with gene expression data

Author(s): Simon J Larsen, Richard Röttger, Harald H H W Schmidt, Jan Baumbach
Published in: Nucleic Acids Research, Issue 47/1, 2018, Page(s) 85-92, ISSN 0305-1048
DOI: 10.1093/nar/gky1176

From single drug targets to synergistic network pharmacology in ischemic stroke

Author(s): Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. López, Jan Baumbach, Harald H. H. W. Schmidt
Published in: Proceedings of the National Academy of Sciences, Issue 116/14, 2019, Page(s) 7129-7136, ISSN 0027-8424
DOI: 10.1073/pnas.1820799116

Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

Author(s): Joaquim Aguirre-Plans, Janet Piñero, Jörg Menche, Ferran Sanz, Laura Furlong, Harald Schmidt, Baldo Oliva, Emre Guney
Published in: Pharmaceuticals, Issue 11/3, 2018, Page(s) 61, ISSN 1424-8247
DOI: 10.3390/ph11030061

Molecular networks in Network Medicine: Development and applications

Author(s): Edwin K. Silverman, Harald H. H. W. Schmidt, Eleni Anastasiadou, Lucia Altucci, Marco Angelini, Lina Badimon, Jean-Luc Balligand, Giuditta Benincasa, Giovambattista Capasso, Federica Conte, Antonella Di Costanzo, Lorenzo Farina, Giulia Fiscon, Laurent Gatto, Michele Gentili, Joseph Loscalzo, Cinzia Marchese, Claudio Napoli, Paola Paci, Manuela Petti, John Quackenbush, Paolo Tieri, Davide Viggiano,
Published in: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020, Page(s) e1489, ISSN 1939-5094
DOI: 10.1002/wsbm.1489

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

Author(s): Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Sebastian Altenhöfer, Ana I. Casas, Mayra P. Pachado, Christopher T. Neullens, Ulla G. Knaus, Harald H.H.W. Schmidt
Published in: Free Radical Biology and Medicine, Issue 148, 2020, Page(s) 60-69, ISSN 0891-5849
DOI: 10.1016/j.freeradbiomed.2019.12.038

Nitric Oxide Synthase Inhibitors into the Clinic at Last

Author(s): Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Thomas Fuchß, Ulrich Grädler, Harald H. H. W. Schmidt, Ajay M. Shah, Alan Wallace, Richard Knowles
Published in: Reactive Oxygen Species - Network Pharmacology and Therapeutic Applications, Issue 264, 2021, Page(s) 169-204
DOI: 10.1007/164_2020_382

NOX Inhibitors: From Bench to Naxibs to Bedside

Author(s): Mahmoud H. Elbatreek, Hermann Mucke, Harald H. H. W. Schmidt
Published in: Reactive Oxygen Species - Network Pharmacology and Therapeutic Applications, Issue 264, 2021, Page(s) 145-168
DOI: 10.1007/164_2020_387