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An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes

Deliverables

Software for detection of pathway co-enrichment for extracting of patient(group)-specific pathways also enriched in target sites of effective drugs

Software for detection of pathway co-enrichment for extracting of patient(group)-specific pathways also enriched in target sites of effective drugs

Diseasome 2.0 network

Diseasome 2.0 network

Searching for OpenAIRE data...

Publications

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Author(s): Ana I. Casas, Pamela W.M. Kleikers, Eva Geuss, Friederike Langhauser, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Martin Hrabê de Angelis, Javier Egea, Manuela G. Lopez, Christoph Kleinschnitz, Harald H.H.W. Schmidt
Published in: Journal of Clinical Investigation, Issue 129/4, 2019, Page(s) 1772-1778, ISSN 0021-9738
DOI: 10.1172/jci124283

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage

Author(s): Mahmoud H. Elbatreek, Mayra P. Pachado, Antonio Cuadrado, Karin Jandeleit-Dahm, Harald H.H.W. Schmidt
Published in: Trends in Endocrinology & Metabolism, Issue 30/5, 2019, Page(s) 312-327, ISSN 1043-2760
DOI: 10.1016/j.tem.2019.02.006

E. coli gene regulatory networks are inconsistent with gene expression data

Author(s): Simon J Larsen, Richard Röttger, Harald H H W Schmidt, Jan Baumbach
Published in: Nucleic Acids Research, Issue 47/1, 2018, Page(s) 85-92, ISSN 0305-1048
DOI: 10.1093/nar/gky1176

From single drug targets to synergistic network pharmacology in ischemic stroke

Author(s): Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. López, Jan Baumbach, Harald H. H. W. Schmidt
Published in: Proceedings of the National Academy of Sciences, Issue 116/14, 2019, Page(s) 7129-7136, ISSN 0027-8424
DOI: 10.1073/pnas.1820799116

Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

Author(s): Joaquim Aguirre-Plans, Janet Piñero, Jörg Menche, Ferran Sanz, Laura Furlong, Harald Schmidt, Baldo Oliva, Emre Guney
Published in: Pharmaceuticals, Issue 11/3, 2018, Page(s) 61, ISSN 1424-8247
DOI: 10.3390/ph11030061