An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes

Informacje na temat projektu

REPO-TRIAL

Identyfikator umowy o grant: 777111

DOI

10.3030/777111

Projekt został zamknięty

Data podpisania przez KE 31 Października 2017

Data rozpoczęcia 1 Lutego 2018

Data zakończenia 31 Stycznia 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 536 775,64

Wkład UE

€ 5 536 772,50

Koordynowany przez

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (4)

Software for detection of pathway co-enrichment for extracting of patient(group)-specific pathways also enriched in target sites of effective drugs
Refined diseasome and drugome 3.5
Drugome 1.0 network

Drugome 10 network

Diseasome 2.0 network

Documents, reports (4)

Publication on study design, study protocol and start: pilot study 2 (TBD)
Publication on study design, study protocol and start: pilot study 1: STROKE
Publication on results of pilot study 2 (TBD)
Publication on results of pilot study 1: STROKE

Websites, patent fillings, videos etc. (3)

Publish an open pre-clinical biobank for pre-clinical animal models related commROCG and other disease phenotypes for both genders

Publish an open preclinical biobank for preclinical animal models related commROCG and other disease phenotypes for both genders

Project brochure and professional templates
Communication and dissemination plan

Publikacje

Peer reviewed articles (21)

Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease

Autorzy: Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Martin Deile, Pavel I. Nedvetsky, Andreas Güldner, César Ibarra-Alvarado, Axel Gödecke, Harald H. H. W. Schmidt
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-66639-w

On the Clinical Pharmacology of Reactive Oxygen Species

Autorzy: Ana I. Casas, Cristian Nogales, Hermann A. M. Mucke, Alexandra Petraina, Antonio Cuadrado, Ana I. Rojo, Pietro Ghezzi, Vincent Jaquet, Fiona Augsburger, Francois Dufrasne, Jalal Soubhye, Soni Deshwal, Moises Di Sante, Nina Kaludercic, Fabio Di Lisa, Harald H. H. W. Schmidt
Opublikowane w: Pharmacological Reviews, Numer 72/4, 2020, Strona(/y) 801-828, ISSN 0031-6997
Wydawca: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/pr.120.019422

De Novo and Supervised Endophenotyping Using Network-Guided Ensemble Learning

Autorzy: Simon J. Larsen, Harald H.H.W. Schmidt, Jan Baumbach
Opublikowane w: Systems Medicine, Numer 3/1, 2020, Strona(/y) 8-21, ISSN 2573-3370
Wydawca: Network and Systems Medicine
DOI: 10.1089/sysm.2019.0008

Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology

Autorzy: Alexandra Petraina, Cristian Nogales, Thomas Krahn, Hermann Mucke, Thomas F Lüscher, Rodolphe Fischmeister, David A Kass, John C Burnett, Jr, Adrian J Hobbs, Harald H H W Schmidt
Opublikowane w: Cardivascular Research, 2021, ISSN 1755-3245
Wydawca: Oxford Academic
DOI: 10.1093/cvr/cvab240

Online bias-aware disease module mining with ROBUST-Web

Autorzy: Suryadipto Sarkar, Marta Lucchetta, Andreas Maier, Mohamed M Abdrabbou, Jan Baumbach, Markus List, Martin H Schaefer, David B Blumenthal
Opublikowane w: Bioinformatics, Numer Volume 39, Numer 6, 2023, ISSN 1367-4811
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btad345

Un-biased housekeeping gene panel selection for high-validity gene expression analysis

Autorzy: Casas, A.I., Hassan, A.A., Manz, Q. et al.
Opublikowane w: Sci Rep 12, 12324, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-15989-8

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes

Autorzy: Pacheco Pachado, Mayra; Casas, Ana I.; Elbatreek, Mahmoud H.; Nogales, Cristian; Guney, Emre; Espay, Alberto J.; Schmidt, Harald H.H.W.
Opublikowane w: Journal of Alzheimer's Disease, Numer vol. 96, no. 1, 2023, Strona(/y) pp. 47-56, 2023, ISSN 1387-2877
Wydawca: IOS Press
DOI: 10.3233/jad-230694

netDx: Software for building interpretable patient classifiers by multi-'omic data integration using patient similarity networks

Autorzy: Shraddha Pai, Philipp Weber, Ruth Isserlin, Hussam Kaka, Shirley Hui, Muhammad Ahmad Shah, Luca Giudice, Rosalba Giugno, Anne Krogh Nøhr, Jan Baumbach, Gary D. Bader
Opublikowane w: F1000Research, Numer 9, 2020, Strona(/y) 1239, ISSN 2046-1402
Wydawca: F1000 Research Ltd.
DOI: 10.12688/f1000research.26429.2

Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis

Autorzy: Florence Ho; Anna M. D. Watson; Mahmoud H. Elbatreek; Pamela W. M. Kleikers; Waheed Khan; Karly C. Sourris; Aozhi Dai; Jay Jha; Harald H. H. W. Schmidt; Karin A. M. Jandeleit-Dahm
Opublikowane w: Sci Rep 12, 11570, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-15706-5

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

Autorzy: Mahmoud H. Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A. Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M. H. Schiffers, Ger M. Janssen, Pamela W. M. Kleikers, Anil Wipat, Jan Baumbach, Jo G. R. De Mey, Harald H. H. W. Schmidt
Opublikowane w: PLOS Biology, Numer 18/11, 2020, Strona(/y) e3000885, ISSN 1545-7885
Wydawca: PLOS Biology
DOI: 10.1371/journal.pbio.3000885

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Autorzy: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling, Jan Baumbach
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17189-2

Robust disease module mining via enumeration of diverse prize-collecting Steiner trees

Autorzy: Judith Bernett, Dominik Krupke, Sepideh Sadegh, Jan Baumbach, Sándor P Fekete, Tim Kacprowski, Markus List, David B Blumenthal
Opublikowane w: Bioinformatics, 2022, ISSN 1460-2059
Wydawca: Oxford Academics

Online in silico validation of disease and gene sets, clusterings, or subnetworks with DIGEST

Autorzy: Klaudia Adamowicz; Andreas Maier; Jan Baumbach; David Blumenthal
Opublikowane w: Briefings in Bioinformatics, Numer Volume 23, Numer 4, 2022, ISSN 1477-4054
Wydawca: Oxford University Press
DOI: 10.14293/s2199-1006.1.sor-.ppp32eqz.v1

Lacking mechanistic disease definitions and corresponding association data hamper progress in network medicine and beyond

Autorzy: Sepideh Sadegh; James Skelton; Elisa Anastasi; Andreas Maier; Klaudia Adamowicz; Anna Möller; Nils M. Kriege; Jaanika Kronberg; Toomas Haller; Tim Kacprowski; Anil Wipat; Jan Baumbach; David B. Blumenthal
Opublikowane w: Nat Commun, Numer 14, 1662, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-37349-4

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Autorzy: Blandine Comte, Jan Baumbach, Arriel Benis, José Basílio, Nataša Debeljak, Åsmund Flobak, Christian Franken, Nissim Harel, Feng He, Martin Kuiper, Juan Albino Méndez Pérez, Estelle Pujos-Guillot, Tadeja Režen, Damjana Rozman, Johannes A. Schmid, Jeanesse Scerri, Paolo Tieri, Kristel Van Steen, Sona Vasudevan, Steven Watterson, Harald H.H.W. Schmidt
Opublikowane w: Network and Systems Medicine, Numer 3/1, 2020, Strona(/y) 67-90, ISSN 2690-5949
Wydawca: Mary Ann Liebert, Inc.
DOI: 10.1089/nsm.2020.0004

Network medicine for disease module identification and drug repurposing with the NeDRex platform

Autorzy: Sepideh Sadegh, James Skelton, Elisa Anastasi, Judith Bernett, David B. Blumenthal, Gihanna Galindez, Marisol Salgado-Albarrán, Olga Lazareva, Keith Flanagan, Simon Cockell, Cristian Nogales, Ana I. Casas, Harald H. H. W. Schmidt, Jan Baumbach, Anil Wipat & Tim Kacprowski
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-27138-2

Molecular networks in Network Medicine: Development and applications

Autorzy: Edwin K. Silverman, Harald H. H. W. Schmidt, Eleni Anastasiadou, Lucia Altucci, Marco Angelini, Lina Badimon, Jean-Luc Balligand, Giuditta Benincasa, Giovambattista Capasso, Federica Conte, Antonella Di Costanzo, Lorenzo Farina, Giulia Fiscon, Laurent Gatto, Michele Gentili, Joseph Loscalzo, Cinzia Marchese, Claudio Napoli, Paola Paci, Manuela Petti, John Quackenbush, Paolo Tieri, Davide Viggiano,
Opublikowane w: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020, Strona(/y) e1489, ISSN 1939-5094
Wydawca: John Wiley and Sons Inc.
DOI: 10.1002/wsbm.1489

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

Autorzy: Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Sebastian Altenhöfer, Ana I. Casas, Mayra P. Pachado, Christopher T. Neullens, Ulla G. Knaus, Harald H.H.W. Schmidt
Opublikowane w: Free Radical Biology and Medicine, Numer 148, 2020, Strona(/y) 60-69, ISSN 0891-5849
Wydawca: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2019.12.038

Cancer driver drug interaction explorer

Autorzy: Michael Hartung; Elisa Anastasi; Zeinab M Mamdouh; Cristian Nogales; Harald H H W Schmidt; Jan Baumbach; Olga Zolotareva; Markus List
Opublikowane w: Nucleic Acids Research, Numer Volume 50, Numer W1, 5 July 2022,, 2022, Strona(/y) Pages W138–W144, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkac384

Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives

Autorzy: Simon F. De Meyer, PhD, Friederike Langhauser, PhD, Steffen Haupeltshofer, PhD, Christoph Kleinschnitz, MD, PhD, Ana I. Casas, PhD
Opublikowane w: Stroke, Numer 53(5), 2022, Strona(/y) 1487-1499, ISSN 1524-4628
Wydawca: AHA/ASA Journals
DOI: 10.1161/strokeaha.122.038733

Network pharmacology: curing causal mechanisms instead of treating symptoms.

Autorzy: Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, and Schmidt HHHW.
Opublikowane w: Trends in Pharmacological Sciences, Numer Vol. 43, No. 2, 2021, ISSN 1873-3735
Wydawca: Cell Press - Elsevier Inc.
DOI: 10.1016/j.tips.2021.11.004

Conference proceedings (4)

NeDRex - an integrative and interactive network medicine platform for drug repurposing

Autorzy: Sadegh S et al.
Opublikowane w: Drgu Repurposing Central - Science Open, Numer Conference name: RExPO22 Conference date: 2-3 September, 2022, 2022
Wydawca: Drgu Repurposing Central - Science Open
DOI: 10.14293/s2199-1006.1.sor-.pppy90r8.v1

A plug-and-play solution to bring network exploration and drug repurposing to biomedical web platforms

Autorzy: Maier A et al.
Opublikowane w: Drug Repurposing Central - Science Open, Numer Conference name: RExPO22 Conference date: 2-3 September, 2022, 2022
Wydawca: Drug Repurposing Central - Science Open
DOI: 10.14293/s2199-1006.1.sor-.pppvbd8w.v1

Network pharmacology and drug repurposing pave the way for precision oncology

Autorzy: Mamdouh Z et al.
Opublikowane w: Drug Repurposing Central - Science Open, Numer Conference name: RExPO22 Conference date: 2-3 September, 2022, 2022
Wydawca: Drug Repurposing Central - Science Open
DOI: 10.14293/s2199-1006.1.sor-.pppdgtlb.v1

Repurposing soluble guanylate cyclase stimulators from one to another isoform within the ROCG signalling module

Autorzy: Alexandra Petraina, Mahmoud H Elbatreek and Christin Elgert et al.
Opublikowane w: Drug Repurposing Central - ScienceOpen, Numer Conference name: RExPO22 Conference date: 2-3 September, 2022, 2022
Wydawca: Drug Repurposing Central - ScienceOpen
DOI: 10.14293/s2199-1006.1.sor-.pppux7cj.v1

Book chapters (2)

Nitric Oxide Synthase Inhibitors into the Clinic at Last

Autorzy: Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Thomas Fuchß, Ulrich Grädler, Harald H. H. W. Schmidt, Ajay M. Shah, Alan Wallace, Richard Knowles
Opublikowane w: Reactive Oxygen Species - Network Pharmacology and Therapeutic Applications, Numer 264, 2021, Strona(/y) 169-204, ISBN 978-3-030-68509-6
Wydawca: Springer International Publishing
DOI: 10.1007/164_2020_382

NOX Inhibitors: From Bench to Naxibs to Bedside

Autorzy: Mahmoud H. Elbatreek, Hermann Mucke, Harald H. H. W. Schmidt
Opublikowane w: Reactive Oxygen Species - Network Pharmacology and Therapeutic Applications, Numer 264, 2021, Strona(/y) 145-168, ISBN 978-3-030-68509-6
Wydawca: Springer International Publishing
DOI: 10.1007/164_2020_387