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Mechanism and function of gasdermin-induced inflammatory cell death

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Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Author(s): Kaiwen W Chen, Benjamin Demarco, Petr Broz
Published in: The EMBO Journal, 39/2, 2020, Page(s) -, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019103397

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Author(s): Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
Published in: Science, 362/6417, 2018, Page(s) 956-960, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar7607

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Author(s): Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Published in: Molecular & Cellular Oncology, 6/4, 2019, Page(s) 1610324, ISSN 2372-3556
Publisher: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1610324

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Author(s): Kaiwen W. Chen, Benjamin Demarco, Petr Broz
Published in: European Journal of Immunology, 2019, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201948254

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly

Author(s): Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz
Published in: The EMBO Journal, 38/10, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019101638

The gasdermins, a protein family executing cell death and inflammation

Author(s): Petr Broz, Pablo Pelegrín, Feng Shao
Published in: Nature Reviews Immunology, 20/3, 2020, Page(s) 143-157, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-019-0228-2

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Author(s): Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder
Published in: Science Immunology, 3/26, 2018, Page(s) eaar6676, ISSN 2470-9468
Publisher: Science Immunology
DOI: 10.1126/sciimmunol.aar6676

Cross talk between intracellular pathogens and cell death

Author(s): Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Published in: Immunological Reviews, 297/1, 2020, Page(s) 174-193, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12892

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Author(s): Benjamin Demarco, James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz
Published in: Science Advances, 6/47, 2020, Page(s) eabc3465, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.abc3465

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Author(s): Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz
Published in: Life Science Alliance, 3/6, 2020, Page(s) e202000735, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202000735

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Author(s): Kaiwen W. Chen, Dave Boucher, Petr Broz
Published in: Cell Research, 29/3, 2019, Page(s) 181-182, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-018-0138-z