Mechanism and function of gasdermin-induced inflammatory cell death

Publicaciones

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

Autores: Morris Degen, José Carlos Santos, Kristyna Pluhackova, Gonzalo Cebrero, Saray Ramos, Gytis Jankevicius, Ella Hartenian, Undina Guillerm, Stefania A. Mari, Bastian Kohl, Daniel J. Müller, Paul Schanda, Timm Maier, Camilo Perez, Christian Sieben, Petr Broz & Sebastian Hiller
Publicado en: Nature, Edición 618,, 2023, Página(s) pages 1065–1071, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-05991-z

Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores

Autores: Sebastian Rühl 1 , Petr Broz 2
Publicado en: JMB, Edición 00222836, 2022, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2021.167246

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Autores: Kaiwen W Chen, Benjamin Demarco, Petr Broz
Publicado en: The EMBO Journal, Edición 39/2, 2020, Página(s) -, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2019103397

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

Autores: Chen K.W., Demarco B., Ramos S., Heilig R., Goris M., Grayczyk J.P., Assenmacher C.A., Radaelli E., Joannas L.D., Henao-Mejia J., Tacchini-Cottier F., Brodsky I.E., Broz P.
Publicado en: PNAS, Edición 10916490, 2021, ISSN 1091-6490
Editor: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2101189118

Unconventional protein secretion by gasdermin pores

Autores: P Broz
Publicado en: Seminars in Immunology, Edición 69, 2023, Página(s) 101811, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/j.smim.2023.101811

NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis

Autores: Ramos S., Hartenian E., Santos J.C., Walch P., Broz P.
Publicado en: The EMBO journal, Edición 43, 2024, Página(s) 7, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.1038/s44318-024-00055-y

Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice

Autores: Fattinger S.A., Maurer L., Geiser P., Bernard E.M., Enz U., Ganguillet S., Gül E., Kroon S., Demarco B., Mack V., Furter M., Barthel M., Pelczar P., Shao F., Broz P., Sellin M.E., Hardt W.D.
Publicado en: PNAS, Edición 120, 2023, Página(s) 48, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2315503120

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Autores: Santos, José Carlos; Boucher, Dave; Schneider, Larisa Kapinos; Demarco, Benjamin; Dilucca, Marisa; Shkarina, Kateryna; Heilig, Rosalie; Chen, Kaiwen W.; Lim, Roderick Y. H.; Broz, Petr
Publicado en: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020), Edición 11, 2020, Página(s) 1, ISSN 2041-1723
Editor: Nature Publishing Group

Selective induction of programmed cell death using synthetic biology tools

Autores: Shkarina K., Broz P.
Publicado en: Seminars in cell & developmental biology, Edición 156, 2024, Página(s) 74-92, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2023.07.012

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Autores: Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
Publicado en: Science, Edición 362/6417, 2018, Página(s) 956-960, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aar7607

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Autores: Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Publicado en: Molecular & Cellular Oncology, Edición 6/4, 2019, Página(s) 1610324, ISSN 2372-3556
Editor: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1610324

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Autores: Kaiwen W. Chen, Benjamin Demarco, Petr Broz
Publicado en: European Journal of Immunology, 2019, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201948254

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly

Autores: Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz
Publicado en: The EMBO Journal, Edición 38/10, 2019, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2019101638

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Autores: Elisabet Bjanes 1 2 , Reyna Garcia Sillas 2 , Rina Matsuda 1 2 , Benjamin Demarco 3 , Timothée Fettrelet 3 , Alexandra A DeLaney 1 2 , Opher S Kornfeld 4 , Bettina L Lee 4 , Eric M Rodríguez López 2 5 , Daniel Grubaugh 2 , Meghan A Wynosky-Dolfi 2 , Naomi H Philip 2 5 , Elise Krespan 2 6 , Dorothy Tovar 2 , Leonel Joannas 2 7 , Daniel P Beiting 2 6 8 , Jorge He
Publicado en: Plos Pathogens, Edición 15537366, 2021, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1009967

The gasdermins, a protein family executing cell death and inflammation

Autores: Petr Broz, Pablo Pelegrín, Feng Shao
Publicado en: Nature Reviews Immunology, Edición 20/3, 2020, Página(s) 143-157, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-019-0228-2

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Autores: Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder
Publicado en: Science Immunology, Edición 3/26, 2018, Página(s) eaar6676, ISSN 2470-9468
Editor: Science Immunology
DOI: 10.1126/sciimmunol.aar6676

Cross talk between intracellular pathogens and cell death

Autores: Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Publicado en: Immunological Reviews, Edición 297/1, 2020, Página(s) 174-193, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.12892

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Autores: Benjamin Demarco, James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz
Publicado en: Science Advances, Edición 6/47, 2020, Página(s) eabc3465, ISSN 2375-2548
Editor: Science
DOI: 10.1126/sciadv.abc3465

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Autores: Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz
Publicado en: Life Science Alliance, Edición 3/6, 2020, Página(s) e202000735, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202000735

Optogenetic activators of apoptosis, necroptosis, and pyroptosis

Autores: Shkarina K., Hasel de Carvalho E., Santos J.C., Ramos S., Leptin M., Broz P.
Publicado en: JCB, Edición 00219525, 2022, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202109038

The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death.

Autores: Hasel de Carvalho E., Dharmadhikari S.S., Shkarina K., Xiong J.R., Reversade B., Broz P., Leptin M.
Publicado en: eLife, Edición 2023, 2023, Página(s) e86373, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.86373

Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines.

Autores: Shkarina K., Broz P.
Publicado en: Bio-protocol, Edición n.a., 2023, Página(s) n.a., ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4762

Active membrane rupture spurs a range of cell deaths

Autores: S. Hiller, P. Broz,
Publicado en: Nature, Edición 00280836, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/d41586-021-00297-4

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Autores: Kaiwen W. Chen, Dave Boucher, Petr Broz
Publicado en: Cell Research, Edición 29/3, 2019, Página(s) 181-182, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-018-0138-z

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