Mechanism and function of gasdermin-induced inflammatory cell death

Publikacje

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

Autorzy: Morris Degen, José Carlos Santos, Kristyna Pluhackova, Gonzalo Cebrero, Saray Ramos, Gytis Jankevicius, Ella Hartenian, Undina Guillerm, Stefania A. Mari, Bastian Kohl, Daniel J. Müller, Paul Schanda, Timm Maier, Camilo Perez, Christian Sieben, Petr Broz & Sebastian Hiller
Opublikowane w: Nature, Numer 618,, 2023, Strona(/y) pages 1065–1071, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-023-05991-z

Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores

Autorzy: Sebastian Rühl 1 , Petr Broz 2
Opublikowane w: JMB, Numer 00222836, 2022, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2021.167246

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Autorzy: Kaiwen W Chen, Benjamin Demarco, Petr Broz
Opublikowane w: The EMBO Journal, Numer 39/2, 2020, Strona(/y) -, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.2019103397

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

Autorzy: Chen K.W., Demarco B., Ramos S., Heilig R., Goris M., Grayczyk J.P., Assenmacher C.A., Radaelli E., Joannas L.D., Henao-Mejia J., Tacchini-Cottier F., Brodsky I.E., Broz P.
Opublikowane w: PNAS, Numer 10916490, 2021, ISSN 1091-6490
Wydawca: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2101189118

Unconventional protein secretion by gasdermin pores

Autorzy: P Broz
Opublikowane w: Seminars in Immunology, Numer 69, 2023, Strona(/y) 101811, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2023.101811

NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis

Autorzy: Ramos S., Hartenian E., Santos J.C., Walch P., Broz P.
Opublikowane w: The EMBO journal, Numer 43, 2024, Strona(/y) 7, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.1038/s44318-024-00055-y

Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice

Autorzy: Fattinger S.A., Maurer L., Geiser P., Bernard E.M., Enz U., Ganguillet S., Gül E., Kroon S., Demarco B., Mack V., Furter M., Barthel M., Pelczar P., Shao F., Broz P., Sellin M.E., Hardt W.D.
Opublikowane w: PNAS, Numer 120, 2023, Strona(/y) 48, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2315503120

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Autorzy: Santos, José Carlos; Boucher, Dave; Schneider, Larisa Kapinos; Demarco, Benjamin; Dilucca, Marisa; Shkarina, Kateryna; Heilig, Rosalie; Chen, Kaiwen W.; Lim, Roderick Y. H.; Broz, Petr
Opublikowane w: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020), Numer 11, 2020, Strona(/y) 1, ISSN 2041-1723
Wydawca: Nature Publishing Group

Selective induction of programmed cell death using synthetic biology tools

Autorzy: Shkarina K., Broz P.
Opublikowane w: Seminars in cell & developmental biology, Numer 156, 2024, Strona(/y) 74-92, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2023.07.012

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Autorzy: Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
Opublikowane w: Science, Numer 362/6417, 2018, Strona(/y) 956-960, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aar7607

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Autorzy: Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Opublikowane w: Molecular & Cellular Oncology, Numer 6/4, 2019, Strona(/y) 1610324, ISSN 2372-3556
Wydawca: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1610324

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Autorzy: Kaiwen W. Chen, Benjamin Demarco, Petr Broz
Opublikowane w: European Journal of Immunology, 2019, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201948254

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly

Autorzy: Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz
Opublikowane w: The EMBO Journal, Numer 38/10, 2019, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.2019101638

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Autorzy: Elisabet Bjanes 1 2 , Reyna Garcia Sillas 2 , Rina Matsuda 1 2 , Benjamin Demarco 3 , Timothée Fettrelet 3 , Alexandra A DeLaney 1 2 , Opher S Kornfeld 4 , Bettina L Lee 4 , Eric M Rodríguez López 2 5 , Daniel Grubaugh 2 , Meghan A Wynosky-Dolfi 2 , Naomi H Philip 2 5 , Elise Krespan 2 6 , Dorothy Tovar 2 , Leonel Joannas 2 7 , Daniel P Beiting 2 6 8 , Jorge He
Opublikowane w: Plos Pathogens, Numer 15537366, 2021, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1009967

The gasdermins, a protein family executing cell death and inflammation

Autorzy: Petr Broz, Pablo Pelegrín, Feng Shao
Opublikowane w: Nature Reviews Immunology, Numer 20/3, 2020, Strona(/y) 143-157, ISSN 1474-1733
Wydawca: Nature Publishing Group
DOI: 10.1038/s41577-019-0228-2

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Autorzy: Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder
Opublikowane w: Science Immunology, Numer 3/26, 2018, Strona(/y) eaar6676, ISSN 2470-9468
Wydawca: Science Immunology
DOI: 10.1126/sciimmunol.aar6676

Cross talk between intracellular pathogens and cell death

Autorzy: Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Opublikowane w: Immunological Reviews, Numer 297/1, 2020, Strona(/y) 174-193, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12892

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Autorzy: Benjamin Demarco, James P. Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E. Brodsky, Kaiwen W. Chen, Petr Broz
Opublikowane w: Science Advances, Numer 6/47, 2020, Strona(/y) eabc3465, ISSN 2375-2548
Wydawca: Science
DOI: 10.1126/sciadv.abc3465

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Autorzy: Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz
Opublikowane w: Life Science Alliance, Numer 3/6, 2020, Strona(/y) e202000735, ISSN 2575-1077
Wydawca: Life Science Alliance
DOI: 10.26508/lsa.202000735

Optogenetic activators of apoptosis, necroptosis, and pyroptosis

Autorzy: Shkarina K., Hasel de Carvalho E., Santos J.C., Ramos S., Leptin M., Broz P.
Opublikowane w: JCB, Numer 00219525, 2022, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202109038

The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death.

Autorzy: Hasel de Carvalho E., Dharmadhikari S.S., Shkarina K., Xiong J.R., Reversade B., Broz P., Leptin M.
Opublikowane w: eLife, Numer 2023, 2023, Strona(/y) e86373, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.86373

Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines.

Autorzy: Shkarina K., Broz P.
Opublikowane w: Bio-protocol, Numer n.a., 2023, Strona(/y) n.a., ISSN 2331-8325
Wydawca: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4762

Active membrane rupture spurs a range of cell deaths

Autorzy: S. Hiller, P. Broz,
Opublikowane w: Nature, Numer 00280836, 2021, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/d41586-021-00297-4

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Autorzy: Kaiwen W. Chen, Dave Boucher, Petr Broz
Opublikowane w: Cell Research, Numer 29/3, 2019, Strona(/y) 181-182, ISSN 1001-0602
Wydawca: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-018-0138-z

Wyszukiwanie danych OpenAIRE...

Publikacje

Udostępnij tę stronę

Pobierz