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Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Deliverables

Critical toxicity data for IVIVE based on existing in vivo sub-acute and (sub)chronic oral and inhalation studies

A written report of tabulated data collected from a variety of sources as described in Task 2.1.

Materials acquisition, physicochemical intrinsic properties and endotoxin evaluation on Tier 1 and 2 ENM

A report summarizing the key features of the ENM sub-sampled or newly synthesized material sub-samples obtained from JRC-Ispra and the Fraunhofer Institute. This will include detail of each ENMs intrinsic physico-chemical characteristics and their endotoxin contamination status.

Management framework & shared server for information management established

A report summarizing the management tools provided to facilitate the day-day project coordination.

PATROLS MODA

Report on the developed MODA for WP6.

Six-monthly E-newsletters documenting updates

Electronic newsletters will be prepared every 6-months for dissemination of PATROLS achievements and updates through a wide contacts distribution list.

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Publications

Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials

Author(s): Victor C. Ude, David M. Brown, Vicki Stone, Helinor J. Johnston
Published in: Journal of Nanobiotechnology, Issue 17/1, 2019, ISSN 1477-3155
DOI: 10.1186/s12951-019-0503-1

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

Author(s): Ali Kermanizadeh, David M. Brown, Wolfgang Moritz, Vicki Stone
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-43870-8

Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor

Author(s): L. Cacopardo, J. Costa, S. Giusti, L. Buoncompagni, S. Meucci, A. Corti, G. Mattei, A. Ahluwalia
Published in: Biosensors and Bioelectronics, Issue 140, 2019, Page(s) 111340, ISSN 0956-5663
DOI: 10.1016/j.bios.2019.111340

Method for Extraction and Quantification of Metal-Based Nanoparticles in Biological Media: Number-Based Biodistribution and Bioconcentration

Author(s): Fazel Abdolahpur Monikh, Latifeh Chupani, Eliska Zusková, Ruud Peters, Marie Vancová, Martina G. Vijver, Petr Porcal, Willie J.G.M. Peijnenburg
Published in: Environmental Science & Technology, Issue 53/2, 2018, Page(s) 946-953, ISSN 0013-936X
DOI: 10.1021/acs.est.8b03715

Allometric Scaling of physiologically-relevant organoids

Author(s): Chiara Magliaro, Andrea Rinaldo, Arti Ahluwalia
Published in: BioRxiv, Issue Regular online, 2019, ISSN 1476-4687
DOI: 10.1101/559682