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In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Deliverables

SILICOFCM Reference Architecture

Innovative, generic approach and reference architecture that will facilitate the deployment of a system for effectiveness in critically ill patientswill be defined, designed and documented.

SILICOFCM Cloud platform

D1.2 is the outcome of Task 1.2. It documents the SILICOFCM Reference Architecture as well as the functional specification of the core architectural components.

Software: Upgrade FE simulation

Finite element programs will be adapted to subject specific data.

Road map on Business Model v1

D9.6 Road map on Business Model(R-Tech, R, M12, PU) Business plan and business model will be developed for our consortium of partners for commercialization of DSS computational platform for cardiomyopathy.

Imaging acquisition data

Medical images for segmentation of left ventricular (LV) myocardial will be provided.

SILICOFCM flyers

The creation and distribution of different flyers for different types of public.

Project Website

The project website will be devloped in order to provide all relevant information about the project.

Project videos

Project video for both training and dissemination purposes with animations.

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Publications

NT‐proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure

Author(s): Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: ESC Heart Failure, Issue 6/2, 2019, Page(s) 449-454, ISSN 2055-5822
DOI: 10.1002/ehf2.12424

A Computational Model for Drug Release from PLGA Implant

Author(s): Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic
Published in: Materials, Issue 11/12, 2018, Page(s) 2416, ISSN 1996-1944
DOI: 10.3390/ma11122416

Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock

Author(s): Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas Müller, Lars S. Maier
Published in: Circulation: Cardiovascular Interventions, Issue 12/2, 2019, ISSN 1941-7640
DOI: 10.1161/circinterventions.118.007425

Association between heart rate variability and haemodynamic response to exercise in chronic heart failure

Author(s): Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: Scandinavian Cardiovascular Journal, Issue 53/2, 2019, Page(s) 77-82, ISSN 1401-7431
DOI: 10.1080/14017431.2019.1590629

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue

Author(s): M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari
Published in: Computers in Biology and Medicine, Issue 108, 2019, Page(s) 288-304, ISSN 0010-4825
DOI: 10.1016/j.compbiomed.2019.03.023

Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments

Author(s): Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Published in: Biophysical Journal, Issue 116/3, 2019, Page(s) 116a, ISSN 0006-3495
DOI: 10.1016/j.bpj.2018.11.654

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Author(s): Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier
Published in: The Journal of General Physiology, Issue 151/5, 2019, Page(s) 680-704, ISSN 0022-1295
DOI: 10.1085/jgp.201812165

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Author(s): Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
Published in: The Journal of General Physiology, Issue 151/1, 2019, Page(s) 18-29, ISSN 0022-1295
DOI: 10.1085/jgp.201812160

Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients

Author(s): Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi
Published in: Biophysical Journal, Issue 116/3, 2019, Page(s) 29a, ISSN 0006-3495
DOI: 10.1016/j.bpj.2018.11.198

A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins

Author(s): J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves
Published in: Analytical Biochemistry, Issue 581, 2019, Page(s) 113338, ISSN 0003-2697
DOI: 10.1016/j.ab.2019.06.009

Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study

Author(s): Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M Seferović, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic
Published in: BMJ Open, Issue 9/4, 2019, Page(s) e028122, ISSN 2044-6055
DOI: 10.1136/bmjopen-2018-028122

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging

Author(s): Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard
Published in: Biophysical Journal, 2019, ISSN 0006-3495
DOI: 10.1016/j.bpj.2019.06.026

Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties

Author(s): Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves
Published in: 2019

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

Author(s): Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves
Published in: BioRxiv, 2019

Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC

Author(s): Federica Sacco
Published in: 2019