In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Deliverables

Innovative, generic approach and reference architecture that will facilitate the deployment of a system for effectiveness in critically ill patientswill be defined, designed and documented.

SILICOFCM Cloud platform

D1.2 is the outcome of Task 1.2. It documents the SILICOFCM Reference Architecture as well as the functional specification of the core architectural components.

Protein and cell data

Specific HCMrelated mutations on human cardiac sarcomere Ca2sensitivity mechanics kinetics and energetics using a large sample collection from genotyped HCM patients

Software: Upgrade FE simulation

Finite element programs will be adapted to subject specific data.

Road map on Business Model v1

D9.6 Road map on Business Model(R-Tech, R, M12, PU) Business plan and business model will be developed for our consortium of partners for commercialization of DSS computational platform for cardiomyopathy.

Road map on Business Model v4

Road map on Business Model forth version

Road map on Business Model v3

Road map on Business Model third version

Requirements Analysis

D1.1 is the outcome of Task 1.1, documenting the review of the State-of-the-Art and the prioritized list of requirements that will be addressed by SILICOFCM.

Road map on Business Model v2

Road map on Business Model - second version.

Imaging acquisition data

Medical images for segmentation of left ventricular (LV) myocardial will be provided.

Interface for drug testing

Interface drug database will be developed interactive uploaddownload applications may also be provided and all connections to the cloud server computational framework will be secured and encrypted

Computational pipelines for drug testing

Computational tools from WP4 WP5 and WP6 in order to simulate all drug testing during development will be integrated

SILICOFCM flyers

The creation and distribution of different flyers for different types of public.

Workflow for drug testing

Workflow for computational modelling for basic drug testing for FCM will be defined

Project Website

The project website will be devloped in order to provide all relevant information about the project.

Project videos

Project video for both training and dissemination purposes with animations.

Publications

Computational Modeling of the Effects of Drugs in HCM and DCM Cardiomyopathies

Author(s): Mijailovich, S.M., Prodanovic, M., Poggesi, C., Regnier, M., Geeves, M.A.
Published in: Biophysical Society, 2022, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.11.1578

Pathophysiology and Treatment of Hypertrophic Cardiomyopathy: New Perspectives

Author(s): Zampieri, M., Berteotti, M., Ferrantini, C., Tassetti, L., Gabriele, M., Tomberli, B., Castelli, G., Cappelli, F., Stefàno, P., Marchionni, N., Coppini, R., Olivotto, I.
Published in: Curr Heart Fail Rep, 2021, ISSN 1546-9530
Publisher: Current Science Inc.
DOI: 10.1007/s11897-021-00523-0

Alpha and beta myosin isoforms and human atrial and ventricular contraction

Author(s): Walklate, J., Ferrantini, C., Johnson, C.A., Tesi, C., Poggesi, C., Geeves, M.A.
Published in: Cell Mol Life Sci, 2021, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-021-03971-y

LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events

Author(s): Gerhard, E.F., Wang, L., Singh, R., Schueler, S., Genovese, L.D., Woods, A., Tang, D., Smith, N.R., Psotka, M.A., Tovey, S., Desai, S.S., Jakovljevic, D.G., MacGowan, G.A., Shah, P.
Published in: Journal of Heart and Lung Transplantation, 2021, ISSN 1053-2498
Publisher: Elsevier BV
DOI: 10.1016/j.healun.2021.08.001

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Author(s): Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Published in: JCI Insight, 5/20, 2020, ISSN 2379-3708
Publisher: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.142446

Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy.

Author(s): Velicki, L., Jakovljevic, D.G., Preveden, A., Golubovic, M., Bjelobrk, M., Ilic, A., Stojsic, S., Barlocco, F., Tafelmeier, M., Okwose, N., Tesic, M.
Published in: BMC Cardiovascular Disorders, 2020, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-020-01807-4

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2'-deoxy-ATP

Author(s): Ma, W., Childers, M., Murray, J., Moussavi-Harami, F., Gong, H., Weiss, R., Daggett, V., Irving, T., Regnier, M.
Published in: J Physiol, 2020, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp280402

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics

Author(s): Milos Kojic, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Vladimir Geroski, Sara Nizzero, Arturas Ziemys, Nenad Filipovic, Mauro Ferrari
Published in: Frontiers in Bioengineering and Biotechnology, 7, 2019, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2019.00381

Prognostic value of peak oxygen uptake in patients supported with left ventricular assist devices (PRO-VAD)

Author(s): Mirza, K.K., Szymanski, M.K., Schmidt, T., de Jonge, N., Brahmbhatt, D.H., Billia, D., Hsu, S., MacGowan, G.A., Jakovljevic, D.G., Agostoni, P., Trombara, F., Jorde, U., Rochlani, Y., Vandersmissen, K., Reiss, N., Russell, S.D., Meyns, M., Gustafsson, F.
Published in: ACC Heart Fail, 2021, ISSN 2213-1779
Publisher: Elsevier BV
DOI: 10.1016/j.jchf.2021.05.021

Shared molecular mechanisms of hypertrophic cardiomyopathy and its clinical presentations: automated molecular mechanisms extraction approach

Author(s): Glavaški, M. and Velicki, L.
Published in: Life, 2021, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11080785

Disease progression of hypertrophic cardiomyopathy: Modeling using machine learning

Author(s): Pičulin, M., Smole, T., Žunkovič, B., Kokalj, E., Robnik-Šikonja, M., Kukar, M., Fotiadis, D.I., Pezoulas, V.C., Tachos, N.S., Barlocco, F. and Mazzarotto, F.
Published in: JMIR medical informatics, 2022, ISSN 2291-9694
Publisher: JMIR Publications
DOI: 10.2196/30483

Humans and machines in biomedical knowledge curation: hypertrophic cardiomyopathy molecular mechanisms’ representation

Author(s): Glavaški, M., Velicki, L.
Published in: BioData Mining, 2021, ISSN 1756-0381
Publisher: BioMed Central
DOI: 10.1186/s13040-021-00279-2

The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle

Author(s): Giulia Vitale, Cecilia Ferrantini, Nicoletta Piroddi, Beatrice Scellini, Josè Manuel Pioner, Barbara Colombini, Chiara Tesi, Corrado Poggesi
Published in: Journal of Muscle Research and Cell Motility, 2019, ISSN 0142-4319
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10974-019-09566-2

Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy

Author(s): Maria Tafelmeier, Andrea Baessler, Stefan Wagner, Bernhard Unsoeld, Andrej Preveden, Fausto Barlocco, Alessia Tomberli, Dejana Popovic, Paul Brennan, Guy A. MacGowan, Arsen Ristic, Lazar Velicki, Iacopo Olivotto, Djordje G. Jakovljevic, Lars S. Maier
Published in: Clinical Cardiology, 43/5, 2020, Page(s) 430-440, ISSN 0160-9289
Publisher: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23346

The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions

Author(s): Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Published in: Journal of Molecular and Cellular Cardiology, 155, 2021, Page(s) 112-124, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2021.02.009

Multiscale modeling of twitch contractions in cardiac trabeculae

Author(s): Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Michael A. Geeves, Michael Regnier
Published in: Journal of General Physiology, 153/3, 2021, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202012604

Ventricular arrhythmias not meeting criteria for terminating cardiopulmonary exercise testing stratify prognosis and disease severity in heart failure of preserved, midrange, and reduced ejection fraction

Author(s): Dejana Popovic, Ross Arena, Djordje Jakovljevic, Arsen Ristic, Marco Guazzi
Published in: Clinical Cardiology, 43/7, 2020, Page(s) 698-705, ISSN 0160-9289
Publisher: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23367

Feasibility of the cardiac output response to stress test in suspected heart failure patients

Author(s): Charman SJ, Okwose NC, Taylor CJ, Bailey K, Fuat A, Ristic A, Mant J, Deaton C, Seferovic PM, Coats AJS, Hobbs FDR, MacGowan GA, Jakovljevic DG.
Published in: Family Practice, 2022, ISSN 0263-2136
Publisher: Oxford University Press
DOI: 10.1093/fampra/cmab184

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy

Author(s): Josè Manuel Pioner, Alessandra Fornaro, Raffaele Coppini, Nicole Ceschia, Leonardo Sacconi, Maria Alice Donati, Silvia Favilli, Corrado Poggesi, Iacopo Olivotto, Cecilia Ferrantini
Published in: Frontiers in Physiology, 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00368

T-tubule remodeling in human hypertrophic cardiomyopathy.

Author(s): Vitale G, Coppini R, Tesi C, Poggesi C, Sacconi L, Ferrantini C
Published in: J Muscle Res Cell Motil, 42 (2), 2021, ISSN 1573-2657
Publisher: Springer
DOI: 10.1007/s10974-020-09591-6

A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy

Author(s): Tim Smole, Bojan Žunkovič, Matej Pičulin, Enja Kokalj, Marko Robnik-Šikonja, Matjaž Kukar, Dimitrios I Fotiadis, Vasileios C Pezoulas, Nikolaos S Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S Maier, Lazar Velicki, Guy A MacGowan, Iacopo Olivotto, Nenad Filipović, Djordje G Jakovljević, Zoran Bosnić
Published in: Computers in Biology and Medicine, 2021, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104648

Computational model for heart tissue with direct use of experimental constitutive relationships

Author(s): Kojic, M., Milosevic, M., Milicevic, B., Geroski, V., Simic, V., Trifunovic, D., Stankovic, G., Filipovic, N.
Published in: Journal of the Serbian Society for Computational Mechanics, 2021, ISSN 1820-6530
Publisher: The Serbian Society for Computational Mechanics (SSCM)
DOI: 10.24874/jsscm.2021.15.01.01

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

Author(s): Prodanovic, M., Geeves, M.A., Poggesi, C., Regnier, M., Mijailovich, S.M.
Published in: Int. J. Mol. Sci, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031135

Author(s): Preveden, A., Golubovic, M., Bjelobrk, M., Miljkovic, T., Ilic, A., Stojsic, S., Gajic, D., Glavaski, M., Maier, L.S., Okwose, N. and Popovic, D.
Published in: Medicina, 2022, ISSN 1010-660X
Publisher: Lietuvos Gydytoju Sajunga
DOI: 10.3390/medicina58020314

Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study

Author(s): Nduka C. Okwose, Leah Avery, Nicola O’Brien, Sophie Cassidy, Sarah J. Charman, Kristian Bailey, Lazar Velicki, Iacopo Olivotto, Paul Brennan, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: Sports Medicine - Open, 5/1, 2019, ISSN 2199-1170
Publisher: Springer
DOI: 10.1186/s40798-019-0216-x

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Author(s): Filomena, M.C., Yamamoto, D.L., Carullo, P., Medvedev, R., Ghisleni, A., Piroddi, N., Scellini, B., Crispino, R., D'Autilia, F., Zhang, J., Felicetta, A., Nemska, S., Serio, S., Tesi, C., Catalucci, D., Linke, W.A., Polishchuk, R., Poggesi, C., Gautel, M., Bang, M.L.
Published in: Elife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58313

The effect of age on mechanisms of exercise tolerance: reduced arteriovenous oxygen difference causes lower oxygen consumption in older people

Author(s): Fuller, A., Okwose, N., Scragg, J., Eggett, C., Luke, P., Bandali, A., Velicki, R., Greaves, L., MacGowan, GA,, Jakovljevic, DG.
Published in: Experimental Gerontology, 2021, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2021.111340

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

Author(s): Karin P. Hammer, Julian Mustroph, Teresa Stauber, Walter Birchmeier, Stefan Wagner, Lars S. Maier
Published in: PLOS ONE, 16/6, 2021, Page(s) e0252649, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0252649

A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Author(s): Vasileios C. Pezoulas; Grigoris I. Grigoriadis; George Gkois; Nikolaos S. Tachos; Tim Smole; Zoran Bosnić; Matej Pičulin; Iacopo Olivotto; Fausto Barlocco; Marko Robnik-Šikonja; Djordje G. Jakovljevic; Andreas V. Goules; Athanasios G. Tzioufas; Dimitrios I. Fotiadis
Published in: Computers in Biology and Medicine, 10, 2021, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104520

Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

Author(s): Miljan Milosevic, Dusica B. Stojanovic, Vladimir Simic, Mirjana Grkovic, Milos Bjelovic, Petar S. Uskokovic, Milos Kojic
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-68117-9

NT‐proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure

Author(s): Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: ESC Heart Failure, 6/2, 2019, Page(s) 449-454, ISSN 2055-5822
Publisher: Wiley Online Library
DOI: 10.1002/ehf2.12424

A Computational Model for Drug Release from PLGA Implant

Author(s): Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic
Published in: Materials, 11/12, 2018, Page(s) 2416, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma11122416

Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock

Author(s): Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas Müller, Lars S. Maier
Published in: Circulation: Cardiovascular Interventions, 12/2, 2019, ISSN 1941-7640
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circinterventions.118.007425

Association between heart rate variability and haemodynamic response to exercise in chronic heart failure

Author(s): Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: Scandinavian Cardiovascular Journal, 53/2, 2019, Page(s) 77-82, ISSN 1401-7431
Publisher: Taylor & Francis
DOI: 10.1080/14017431.2019.1590629

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue

Author(s): M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari
Published in: Computers in Biology and Medicine, 108, 2019, Page(s) 288-304, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2019.03.023

Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments

Author(s): Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Published in: Biophysical Journal, 116/3, 2019, Page(s) 116a, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.654

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Author(s): Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier
Published in: The Journal of General Physiology, 151/5, 2019, Page(s) 680-704, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.201812165

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Author(s): Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
Published in: The Journal of General Physiology, 151/1, 2019, Page(s) 18-29, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.201812160

Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients

Author(s): Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi
Published in: Biophysical Journal, 116/3, 2019, Page(s) 29a, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.198

A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins

Author(s): J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves
Published in: Analytical Biochemistry, 581, 2019, Page(s) 113338, ISSN 0003-2697
Publisher: Academic Press
DOI: 10.1016/j.ab.2019.06.009

Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study

Author(s): Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M Seferović, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic
Published in: BMJ Open, 9/4, 2019, Page(s) e028122, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-028122

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging

Author(s): Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard
Published in: Biophysical Journal, 2019, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2019.06.026

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Author(s): Raffaele Coppini, Cecilia Ferrantini, Josè Manuel Pioner, Lorenzo Santini, Zhinuo J. Wang, Chiara Palandri, Marina Scardigli, Giulia Vitale, Leonardo Sacconi, Pierluigi Stefàno, Laura Flink, Katherine Riedy, Francesco Saverio Pavone, Elisabetta Cerbai, Corrado Poggesi, Alessandro Mugelli, Alfonso Bueno-Orovio, Iacopo Olivotto, Mark V. Sherrid
Published in: JACC: Basic to Translational Science, 4/7, 2019, Page(s) 795-813, ISSN 2452-302X
Publisher: American College of Cardiology
DOI: 10.1016/j.jacbts.2019.06.004

Prognostic Value of NT-Pro Brain Natriuretic Peptide During Exercise Recovery in Ischemic Heart Failure of Reduced, Midrange, and Preserved Ejection Fraction

Author(s): Djordjevic T, Arena R, Guazzi M, Popovic D.
Published in: J Cardiopulm Rehabil Prev, 2021, ISSN 1932-7501
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hcr.0000000000000531

Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic deformation

Author(s): Boban Stojanovic, Marina Svicevic, Ana Kaplarevic-Malisic, Richard J. Gilbert, Srboljub M. Mijailovich
Published in: Journal of Computational Science, 39, 2020, Page(s) 101062, ISSN 1877-7503
Publisher: Elsevier BV
DOI: 10.1016/j.jocs.2019.101062

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Author(s): Sarah J. Charman, Lazar Velicki, Nduka C. Okwose, Amy Harwood, Gordon McGregor, Arsen Ristic, Prithwish Banerjee, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Published in: ESC Heart Failure, 8/1, 2021, Page(s) 175-182, ISSN 2055-5822
Publisher: European Society of Cardiology
DOI: 10.1002/ehf2.13061

Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data

Author(s): Srboljub M. Mijailovich, Momcilo Prodanovic, Thomas C. Irving
Published in: International Journal of Molecular Sciences, 20/23, 2019, Page(s) 6044, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20236044

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

Author(s): Matthew Carter Childers, Michael Geeves, Valerie Daggett, Michael Regnier
Published in: Archives of Biochemistry and Biophysics, 699, 2021, Page(s) 108733, ISSN 0003-9861
Publisher: Academic Press
DOI: 10.1016/j.abb.2020.108733

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Author(s): Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Published in: International Journal of Molecular Sciences, 20/15, 2019, Page(s) 3799, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20153799

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Author(s): Walklate J, Kao K, Regnier M, Geeves MA.
Published in: J Biol Chem, 2022, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101640

Identification of sequence changes in myosin II that adjust muscle contraction velocity

Author(s): Chloe A. Johnson, Jake E. McGreig, Sarah T. Jeanfavre, Jonathan Walklate, Carlos D. Vera, Marta Farré, Daniel P. Mulvihill, Anthony J. Baines, Martin Ridout, Leslie A. Leinwand, Mark N. Wass, Michael A. Geeves
Published in: PLOS Biology, 19/6, 2021, Page(s) e3001248, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3001248

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Author(s): Francesco Mazzarotto, Iacopo Olivotto, Beatrice Boschi, Francesca Girolami, Corrado Poggesi, Paul J. R. Barton, Roddy Walsh
Published in: Journal of the American Heart Association, 9/8, 2020, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.119.015473

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Author(s): Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Giulia Vitale, Josè Manuel Pioner, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi
Published in: Journal of General Physiology, 153/7, 2021, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202012789

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Author(s): Carlos D. Vera, Chloe A. Johnson, Jonathan Walklate, Arjun Adhikari, Marina Svicevic, Srboljub M. Mijailovich, Ariana C. Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Michael A. Geeves, Leslie A. Leinwand
Published in: Journal of Biological Chemistry, 294/46, 2019, Page(s) 17451-17462, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.010563

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Author(s): Matthew H. Doran, Elumalai Pavadai, Michael J. Rynkiewicz, Jonathan Walklate, Esther Bullitt, Jeffrey R. Moore, Michael Regnier, Michael A. Geeves, William Lehman
Published in: Biophysical Journal, 119/4, 2020, Page(s) 821-830, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.07.006

Comparison of three U-Net family architectures for left ventricular myocardial wall automatic segmentation.

Author(s): Grigoris I Grigoriadis, Maria Roumpi, Dimitrios Zaridis, Vasilis C Pezoulas, Aidonis Rammos, Nikolaos S. Tachos, Katerina K Naka, & Dimitrios I. Fotiadis. (2021, December 9).
Published in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Dec 2021, 2021, Page(s) -
Publisher: IEEE
DOI: 10.5281/zenodo.6359041

HCM Map: Interactive Knowledge Resource About Molecular Mechanisms of Hypertrophic Cardiomyopathy

Author(s): Glavaški Mila; Velicki Lazar
Published in: 10, 2020
Publisher: Zenodo
DOI: 10.5281/zenodo.4293372

BIOMECHANICS OF LEFT VENTRICLE AND IN SILICO DRUG TESTING

Author(s): Nenad Filipovic, Bogdan Milicevic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski and Milos Kojic
Published in: 8th International Congress of the Serbian Society of Mechanics, 2021
Publisher: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068845

COUPLED OHARA-RUDY NUMERICAL MODEL FOR HEART ELECTROMECHANICS

Author(s): Vladimir Geroski, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic, Nenad Filipovic, Milos Kojic
Published in: 8th International Congress of the Serbian Society of Mechanics, 2021
Publisher: 8th International Congress of the Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068891

LEFT VENTRICLE MODEL GENERATED FROM ECHOCARDIOGRAPHIC DATA

Author(s): Bogdan Milicevic, Miljan Milosevic, Vladimir Geroski, Vladimir Simic, Danijela Trifunovic, Nenad Filipovic, Milos Kojic
Published in: 8th International Congress of the Serbian Society of Mechanics, 2021
Publisher: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068847

Towards the development of a unified virtual population model in hypertrophic cardiomyopathy

Author(s): Grigoris I. Grigoriadis, Vasileios C. Pezoulas, Maria Roumpi, George Gkois, Nikolaos S. Tachos, Momcilo Prodanovic, Danica Prodanovic, Boban Stojanovic, Srboljub M. Mijailovich, Nenad Filipovic, & Dimitrios I. Fotiadis.
Published in: 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI), July 2021, 2021, Page(s) -
Publisher: IEEE
DOI: 10.5281/zenodo.6358609

Estimation of Shear Stress Variation in Extracellular Matrix Caused by Duchenne Muscular Dystrophy

Author(s): Momcilo Prodanovic; Danica Prodanovic; Boban Stojanovic; Nenad Filipovic; Gordana R. Jovicic; Srboljub M. Mijailovich
Published in: Crossref, 17, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635402

Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties

Author(s): Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves
Published in: 2019
Publisher: bioRxiv

Computational model for simulation of left ventricle behaviour during heart beat

Author(s): Miljan Milosevic; Bogdan Milicevic; Vladimir Simic; Vladimir Geroski; Nenad Filipovic; Milos Kojic
Published in: Crossref, 28, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635417

Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior

Author(s): Momcilo Prodanovic; Boban Stojanovic; Danica Prodanovic; Nenad Filipovic; Srboljub M. Mijailovich
Published in: Crossref, 29, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635428

Generation of virtual patient data for in-silico cardiomyopathies drug development using tree ensembles: a comparative study

Author(s): Vasileios C. Pezoulas; Grigorios I. Grigoriadis; Nikolaos S. Tachos; Fausto Barlocco; Iacopo Olivotto; Dimitrios I. Fotiadis
Published in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), July 20-24, 2020, 2020
Publisher: IEEE
DOI: 10.5281/zenodo.4050541

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model

Author(s): Vladimir Simic; Miljan Milosevic; Igor Saveljic; Bogdan Milicevic; Nenad Filipovic; Milos Kojic
Published in: Crossref, 14, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635284

FLUID-ELECTRO-MECHANICAL PARAMETRIC MODEL OF THE LEFT VENTRICLE

Author(s): Vladimir Simic, Miljan Milosevic, Bogdan Milicevic, Vladimir Geroski, Nenad Filipovic, Milos Kojic
Published in: 8th International Congress of the Serbian Society of Mechanics, 2021
Publisher: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068864

Variational Gaussian Mixture Models with robust Dirichlet concentration priors for virtual population generation in hypertrophic cardiomyopathy: a comparison study.

Author(s): Vasileios C. Pezoulas, Grigorios I. Grigoriadis, Nikolaos S. Tachos, Fausto Barlocco, Iacopo Olivotto, & Dimitrios I. Fotiadis. (2021, December 9).
Published in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Dec 2021, 2021
Publisher: IEEE
DOI: 10.5281/zenodo.6358958

Inhibitory potency of Valsartan/Sacubitril drug combination: molecular docking simulations

Author(s): Jelena Dorovic Jovanovic; Zoran Markovic; Mihajlo Kokanovic; Nenad Filipovic; Marijana Stanojevic
Published in: Crossref, 30, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635185

Semi-Automatic Left Ventricle Model Generation

Author(s): Bogdan Milicevic; Milian Milosevic; Vladimir Simic; Danijela Trifunovic; Nenad Filipovic; Milos Kojic
Published in: Crossref, 11, 2021
Publisher: IEEE
DOI: 10.1109/bibe52308.2021.9635408

Generation of virtual patients for in silico cardiomyopathies drug development

Author(s): Vasileios C. Pezoulas; Nikolaos S. Tachos; Dimitrios I. Fotiadis
Published in: IEEE BIBE 2019, 28-30 October 2019, 2019
Publisher: IEEE
DOI: 10.5281/zenodo.4050523

Composite Smeared Finite Element – Application to Electrical Field

Author(s): Vladimir Geroski, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Nenad Filipovic, Milos Kojic
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, 11, 2020, Page(s) 35-43, ISBN 978-3-030-43657-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_4

Finite Element Models with Smeared Fields Within Tissue – A Review of the Current Developments

Author(s): Milos Kojic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski, Bogdan Milicevic, Arturas Ziemys, Nenad Filipovic
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, 11, 2020, Page(s) 22-34, ISBN 978-3-030-43657-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_3

Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs

Author(s): Vladimir Simic, Miljan Milosevic, Arturas Ziemys, Milos Kojic
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, 11, 2020, Page(s) 44-52, ISBN 978-3-030-43657-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_5

Heart Mechanical Model Based on Holzapfel Experiments

Author(s): Milos Kojic, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, 11, 2020, Page(s) 12-21, ISBN 978-3-030-43657-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_2

Tuning Cooperativity of Calcium Activation in Cardiac Muscle

Author(s): Momcilo Prodanovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Srboljub M. Mijailovich
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, 11, 2020, Page(s) 53-63, ISBN 978-3-030-43657-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_6

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

Author(s): Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves
Published in: BioRxiv, 2019
Publisher: bioRxiv

Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC

Author(s): Federica Sacco
Published in: 2019
Publisher: Federica Sacco

Datasets

Additional file 7 of Humans and machines in biomedical knowledge curation: hypertrophic cardiomyopathy molecular mechanisms’ representation

Author(s): Glavaški, Mila; Velicki, Lazar
Published in: figshare

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