In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Informazioni relative al progetto

SILICOFCM

ID dell’accordo di sovvenzione: 777204

DOI 10.3030/777204

Progetto chiuso

Data della firma CE 8 Maggio 2018

Data di avvio 1 Giugno 2018

Data di completamento 28 Febbraio 2022

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 5 507 441,25

Contributo UE € 5 507 441,25

Coordinato da

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Serbia

Risultati finali

Documents, reports (11)

SILICOFCM Reference Architecture

Innovative generic approach and reference architecture that will facilitate the deployment of a system for effectiveness in critically ill patientswill be defined designed and documented

SILICOFCM Cloud platform

D12 is the outcome of Task 12 It documents the SILICOFCM Reference Architecture as well as the functional specification of the core architectural components

Protein and cell data

Specific HCMrelated mutations on human cardiac sarcomere Ca2sensitivity mechanics kinetics and energetics using a large sample collection from genotyped HCM patients

Software: Upgrade FE simulation

Finite element programs will be adapted to subject specific data

Road map on Business Model v1

D96 Road map on Business ModelRTech R M12 PUBusiness plan and business model will be developed for our consortium of partners for commercialization of DSS computational platform for cardiomyopathy

Road map on Business Model v4

Road map on Business Model forth version

Road map on Business Model v3

Road map on Business Model third version

Physiological experiments

Basic physiological experiments for heart disease will be conducted

Requirements Analysis

D11 is the outcome of Task 11 documenting the review of the StateoftheArt and the prioritized list of requirements that will be addressed by SILICOFCM

Road map on Business Model v2

Road map on Business Model second version

Imaging acquisition data

Medical images for segmentation of left ventricular LV myocardial will be provided

Other (6)

Interface for drug testing

Interface drug database will be developed interactive uploaddownload applications may also be provided and all connections to the cloud server computational framework will be secured and encrypted

Computational pipelines for drug testing

Computational tools from WP4 WP5 and WP6 in order to simulate all drug testing during development will be integrated

SILICOFCM flyers

The creation and distribution of different flyers for different types of public

Workflow for drug testing

Workflow for computational modelling for basic drug testing for FCM will be defined

Project Website

The project website will be devloped in order to provide all relevant information about the project

Project videos

Project video for both training and dissemination purposes with animations

Pubblicazioni

Peer reviewed articles (55)

Computational Modeling of the Effects of Drugs in HCM and DCM Cardiomyopathies

Autori: Mijailovich, S.M., Prodanovic, M., Poggesi, C., Regnier, M., Geeves, M.A.
Pubblicato in: Biophysical Society, 2022, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2021.11.1578

Pathophysiology and Treatment of Hypertrophic Cardiomyopathy: New Perspectives

Autori: Zampieri, M., Berteotti, M., Ferrantini, C., Tassetti, L., Gabriele, M., Tomberli, B., Castelli, G., Cappelli, F., Stefàno, P., Marchionni, N., Coppini, R., Olivotto, I.
Pubblicato in: Curr Heart Fail Rep, 2021, ISSN 1546-9530
Editore: Current Science Inc.
DOI: 10.1007/s11897-021-00523-0

Alpha and beta myosin isoforms and human atrial and ventricular contraction

Autori: Walklate, J., Ferrantini, C., Johnson, C.A., Tesi, C., Poggesi, C., Geeves, M.A.
Pubblicato in: Cell Mol Life Sci, 2021, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-021-03971-y

LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events

Autori: Gerhard, E.F., Wang, L., Singh, R., Schueler, S., Genovese, L.D., Woods, A., Tang, D., Smith, N.R., Psotka, M.A., Tovey, S., Desai, S.S., Jakovljevic, D.G., MacGowan, G.A., Shah, P.
Pubblicato in: Journal of Heart and Lung Transplantation, 2021, ISSN 1053-2498
Editore: Elsevier BV
DOI: 10.1016/j.healun.2021.08.001

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Autori: Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Pubblicato in: JCI Insight, Numero 5/20, 2020, ISSN 2379-3708
Editore: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.142446

Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy.

Autori: Velicki, L., Jakovljevic, D.G., Preveden, A., Golubovic, M., Bjelobrk, M., Ilic, A., Stojsic, S., Barlocco, F., Tafelmeier, M., Okwose, N., Tesic, M.
Pubblicato in: BMC Cardiovascular Disorders, 2020, ISSN 1471-2261
Editore: BioMed Central
DOI: 10.1186/s12872-020-01807-4

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2'-deoxy-ATP

Autori: Ma, W., Childers, M., Murray, J., Moussavi-Harami, F., Gong, H., Weiss, R., Daggett, V., Irving, T., Regnier, M.
Pubblicato in: J Physiol, 2020, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp280402

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics

Autori: Milos Kojic, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Vladimir Geroski, Sara Nizzero, Arturas Ziemys, Nenad Filipovic, Mauro Ferrari
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 7, 2019, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2019.00381

Prognostic value of peak oxygen uptake in patients supported with left ventricular assist devices (PRO-VAD)

Autori: Mirza, K.K., Szymanski, M.K., Schmidt, T., de Jonge, N., Brahmbhatt, D.H., Billia, D., Hsu, S., MacGowan, G.A., Jakovljevic, D.G., Agostoni, P., Trombara, F., Jorde, U., Rochlani, Y., Vandersmissen, K., Reiss, N., Russell, S.D., Meyns, M., Gustafsson, F.
Pubblicato in: ACC Heart Fail, 2021, ISSN 2213-1779
Editore: Elsevier BV
DOI: 10.1016/j.jchf.2021.05.021

Shared molecular mechanisms of hypertrophic cardiomyopathy and its clinical presentations: automated molecular mechanisms extraction approach

Autori: Glavaški, M. and Velicki, L.
Pubblicato in: Life, 2021, ISSN 2075-1729
Editore: MDPI
DOI: 10.3390/life11080785

Disease progression of hypertrophic cardiomyopathy: Modeling using machine learning

Autori: Pičulin, M., Smole, T., Žunkovič, B., Kokalj, E., Robnik-Šikonja, M., Kukar, M., Fotiadis, D.I., Pezoulas, V.C., Tachos, N.S., Barlocco, F. and Mazzarotto, F.
Pubblicato in: JMIR medical informatics, 2022, ISSN 2291-9694
Editore: JMIR Publications
DOI: 10.2196/30483

Humans and machines in biomedical knowledge curation: hypertrophic cardiomyopathy molecular mechanisms’ representation

Autori: Glavaški, M., Velicki, L.
Pubblicato in: BioData Mining, 2021, ISSN 1756-0381
Editore: BioMed Central
DOI: 10.1186/s13040-021-00279-2

The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle

Autori: Giulia Vitale, Cecilia Ferrantini, Nicoletta Piroddi, Beatrice Scellini, Josè Manuel Pioner, Barbara Colombini, Chiara Tesi, Corrado Poggesi
Pubblicato in: Journal of Muscle Research and Cell Motility, 2019, ISSN 0142-4319
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10974-019-09566-2

Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy

Autori: Maria Tafelmeier, Andrea Baessler, Stefan Wagner, Bernhard Unsoeld, Andrej Preveden, Fausto Barlocco, Alessia Tomberli, Dejana Popovic, Paul Brennan, Guy A. MacGowan, Arsen Ristic, Lazar Velicki, Iacopo Olivotto, Djordje G. Jakovljevic, Lars S. Maier
Pubblicato in: Clinical Cardiology, Numero 43/5, 2020, Pagina/e 430-440, ISSN 0160-9289
Editore: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23346

The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions

Autori: Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 155, 2021, Pagina/e 112-124, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2021.02.009

Multiscale modeling of twitch contractions in cardiac trabeculae

Autori: Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Michael A. Geeves, Michael Regnier
Pubblicato in: Journal of General Physiology, Numero 153/3, 2021, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.202012604

Ventricular arrhythmias not meeting criteria for terminating cardiopulmonary exercise testing stratify prognosis and disease severity in heart failure of preserved, midrange, and reduced ejection fraction

Autori: Dejana Popovic, Ross Arena, Djordje Jakovljevic, Arsen Ristic, Marco Guazzi
Pubblicato in: Clinical Cardiology, Numero 43/7, 2020, Pagina/e 698-705, ISSN 0160-9289
Editore: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23367

Feasibility of the cardiac output response to stress test in suspected heart failure patients

Autori: Charman SJ, Okwose NC, Taylor CJ, Bailey K, Fuat A, Ristic A, Mant J, Deaton C, Seferovic PM, Coats AJS, Hobbs FDR, MacGowan GA, Jakovljevic DG.
Pubblicato in: Family Practice, 2022, ISSN 0263-2136
Editore: Oxford University Press
DOI: 10.1093/fampra/cmab184

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy

Autori: Josè Manuel Pioner, Alessandra Fornaro, Raffaele Coppini, Nicole Ceschia, Leonardo Sacconi, Maria Alice Donati, Silvia Favilli, Corrado Poggesi, Iacopo Olivotto, Cecilia Ferrantini
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00368

T-tubule remodeling in human hypertrophic cardiomyopathy.

Autori: Vitale G, Coppini R, Tesi C, Poggesi C, Sacconi L, Ferrantini C
Pubblicato in: J Muscle Res Cell Motil, Numero 42 (2), 2021, ISSN 1573-2657
Editore: Springer
DOI: 10.1007/s10974-020-09591-6

A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy

Autori: Tim Smole, Bojan Žunkovič, Matej Pičulin, Enja Kokalj, Marko Robnik-Šikonja, Matjaž Kukar, Dimitrios I Fotiadis, Vasileios C Pezoulas, Nikolaos S Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S Maier, Lazar Velicki, Guy A MacGowan, Iacopo Olivotto, Nenad Filipović, Djordje G Jakovljević, Zoran Bosnić
Pubblicato in: Computers in Biology and Medicine, 2021, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104648

Computational model for heart tissue with direct use of experimental constitutive relationships

Autori: Kojic, M., Milosevic, M., Milicevic, B., Geroski, V., Simic, V., Trifunovic, D., Stankovic, G., Filipovic, N.
Pubblicato in: Journal of the Serbian Society for Computational Mechanics, 2021, ISSN 1820-6530
Editore: The Serbian Society for Computational Mechanics (SSCM)
DOI: 10.24874/jsscm.2021.15.01.01

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

Autori: Prodanovic, M., Geeves, M.A., Poggesi, C., Regnier, M., Mijailovich, S.M.
Pubblicato in: Int. J. Mol. Sci, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031135

Gender Related Differences in the Clinical Presentation of Hypertrophic Cardiomyopathy—An Analysis from the SILICOFCM Database

Autori: Preveden, A., Golubovic, M., Bjelobrk, M., Miljkovic, T., Ilic, A., Stojsic, S., Gajic, D., Glavaski, M., Maier, L.S., Okwose, N. and Popovic, D.
Pubblicato in: Medicina, 2022, ISSN 1010-660X
Editore: Lietuvos Gydytoju Sajunga
DOI: 10.3390/medicina58020314

Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study

Autori: Nduka C. Okwose, Leah Avery, Nicola O’Brien, Sophie Cassidy, Sarah J. Charman, Kristian Bailey, Lazar Velicki, Iacopo Olivotto, Paul Brennan, Guy A. MacGowan, Djordje G. Jakovljevic
Pubblicato in: Sports Medicine - Open, Numero 5/1, 2019, ISSN 2199-1170
Editore: Springer
DOI: 10.1186/s40798-019-0216-x

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Autori: Filomena, M.C., Yamamoto, D.L., Carullo, P., Medvedev, R., Ghisleni, A., Piroddi, N., Scellini, B., Crispino, R., D'Autilia, F., Zhang, J., Felicetta, A., Nemska, S., Serio, S., Tesi, C., Catalucci, D., Linke, W.A., Polishchuk, R., Poggesi, C., Gautel, M., Bang, M.L.
Pubblicato in: Elife, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.58313

The effect of age on mechanisms of exercise tolerance: reduced arteriovenous oxygen difference causes lower oxygen consumption in older people

Autori: Fuller, A., Okwose, N., Scragg, J., Eggett, C., Luke, P., Bandali, A., Velicki, R., Greaves, L., MacGowan, GA,, Jakovljevic, DG.
Pubblicato in: Experimental Gerontology, 2021, ISSN 0531-5565
Editore: Elsevier BV
DOI: 10.1016/j.exger.2021.111340

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

Autori: Karin P. Hammer, Julian Mustroph, Teresa Stauber, Walter Birchmeier, Stefan Wagner, Lars S. Maier
Pubblicato in: PLOS ONE, Numero 16/6, 2021, Pagina/e e0252649, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0252649

A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Autori: Vasileios C. Pezoulas; Grigoris I. Grigoriadis; George Gkois; Nikolaos S. Tachos; Tim Smole; Zoran Bosnić; Matej Pičulin; Iacopo Olivotto; Fausto Barlocco; Marko Robnik-Šikonja; Djordje G. Jakovljevic; Andreas V. Goules; Athanasios G. Tzioufas; Dimitrios I. Fotiadis
Pubblicato in: Computers in Biology and Medicine, Numero 10, 2021, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104520

Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

Autori: Miljan Milosevic, Dusica B. Stojanovic, Vladimir Simic, Mirjana Grkovic, Milos Bjelovic, Petar S. Uskokovic, Milos Kojic
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-68117-9

NT‐proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure

Autori: Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Pubblicato in: ESC Heart Failure, Numero 6/2, 2019, Pagina/e 449-454, ISSN 2055-5822
Editore: Wiley Online Library
DOI: 10.1002/ehf2.12424

A Computational Model for Drug Release from PLGA Implant

Autori: Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic
Pubblicato in: Materials, Numero 11/12, 2018, Pagina/e 2416, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma11122416

Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock

Autori: Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas Müller, Lars S. Maier
Pubblicato in: Circulation: Cardiovascular Interventions, Numero 12/2, 2019, ISSN 1941-7640
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circinterventions.118.007425

Association between heart rate variability and haemodynamic response to exercise in chronic heart failure

Autori: Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
Pubblicato in: Scandinavian Cardiovascular Journal, Numero 53/2, 2019, Pagina/e 77-82, ISSN 1401-7431
Editore: Taylor & Francis
DOI: 10.1080/14017431.2019.1590629

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue

Autori: M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari
Pubblicato in: Computers in Biology and Medicine, Numero 108, 2019, Pagina/e 288-304, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2019.03.023

Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments

Autori: Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Pubblicato in: Biophysical Journal, Numero 116/3, 2019, Pagina/e 116a, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.654

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Autori: Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier
Pubblicato in: The Journal of General Physiology, Numero 151/5, 2019, Pagina/e 680-704, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.201812165

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Autori: Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
Pubblicato in: The Journal of General Physiology, Numero 151/1, 2019, Pagina/e 18-29, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.201812160

Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients

Autori: Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi
Pubblicato in: Biophysical Journal, Numero 116/3, 2019, Pagina/e 29a, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.198

A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins

Autori: J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves
Pubblicato in: Analytical Biochemistry, Numero 581, 2019, Pagina/e 113338, ISSN 0003-2697
Editore: Academic Press
DOI: 10.1016/j.ab.2019.06.009

Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study

Autori: Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M Seferović, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic
Pubblicato in: BMJ Open, Numero 9/4, 2019, Pagina/e e028122, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-028122

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging

Autori: Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard
Pubblicato in: Biophysical Journal, 2019, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2019.06.026

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Autori: Raffaele Coppini, Cecilia Ferrantini, Josè Manuel Pioner, Lorenzo Santini, Zhinuo J. Wang, Chiara Palandri, Marina Scardigli, Giulia Vitale, Leonardo Sacconi, Pierluigi Stefàno, Laura Flink, Katherine Riedy, Francesco Saverio Pavone, Elisabetta Cerbai, Corrado Poggesi, Alessandro Mugelli, Alfonso Bueno-Orovio, Iacopo Olivotto, Mark V. Sherrid
Pubblicato in: JACC: Basic to Translational Science, Numero 4/7, 2019, Pagina/e 795-813, ISSN 2452-302X
Editore: American College of Cardiology
DOI: 10.1016/j.jacbts.2019.06.004

Prognostic Value of NT-Pro Brain Natriuretic Peptide During Exercise Recovery in Ischemic Heart Failure of Reduced, Midrange, and Preserved Ejection Fraction

Autori: Djordjevic T, Arena R, Guazzi M, Popovic D.
Pubblicato in: J Cardiopulm Rehabil Prev, 2021, ISSN 1932-7501
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hcr.0000000000000531

Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic deformation

Autori: Boban Stojanovic, Marina Svicevic, Ana Kaplarevic-Malisic, Richard J. Gilbert, Srboljub M. Mijailovich
Pubblicato in: Journal of Computational Science, Numero 39, 2020, Pagina/e 101062, ISSN 1877-7503
Editore: Elsevier BV
DOI: 10.1016/j.jocs.2019.101062

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Autori: Sarah J. Charman, Lazar Velicki, Nduka C. Okwose, Amy Harwood, Gordon McGregor, Arsen Ristic, Prithwish Banerjee, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Pubblicato in: ESC Heart Failure, Numero 8/1, 2021, Pagina/e 175-182, ISSN 2055-5822
Editore: European Society of Cardiology
DOI: 10.1002/ehf2.13061

Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data

Autori: Srboljub M. Mijailovich, Momcilo Prodanovic, Thomas C. Irving
Pubblicato in: International Journal of Molecular Sciences, Numero 20/23, 2019, Pagina/e 6044, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20236044

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

Autori: Matthew Carter Childers, Michael Geeves, Valerie Daggett, Michael Regnier
Pubblicato in: Archives of Biochemistry and Biophysics, Numero 699, 2021, Pagina/e 108733, ISSN 0003-9861
Editore: Academic Press
DOI: 10.1016/j.abb.2020.108733

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Autori: Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Pubblicato in: International Journal of Molecular Sciences, Numero 20/15, 2019, Pagina/e 3799, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20153799

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Autori: Walklate J, Kao K, Regnier M, Geeves MA.
Pubblicato in: J Biol Chem, 2022, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101640

Identification of sequence changes in myosin II that adjust muscle contraction velocity

Autori: Chloe A. Johnson, Jake E. McGreig, Sarah T. Jeanfavre, Jonathan Walklate, Carlos D. Vera, Marta Farré, Daniel P. Mulvihill, Anthony J. Baines, Martin Ridout, Leslie A. Leinwand, Mark N. Wass, Michael A. Geeves
Pubblicato in: PLOS Biology, Numero 19/6, 2021, Pagina/e e3001248, ISSN 1545-7885
Editore: PLOS
DOI: 10.1371/journal.pbio.3001248

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Autori: Francesco Mazzarotto, Iacopo Olivotto, Beatrice Boschi, Francesca Girolami, Corrado Poggesi, Paul J. R. Barton, Roddy Walsh
Pubblicato in: Journal of the American Heart Association, Numero 9/8, 2020, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.119.015473

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Autori: Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Giulia Vitale, Josè Manuel Pioner, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi
Pubblicato in: Journal of General Physiology, Numero 153/7, 2021, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.202012789

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Autori: Carlos D. Vera, Chloe A. Johnson, Jonathan Walklate, Arjun Adhikari, Marina Svicevic, Srboljub M. Mijailovich, Ariana C. Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Michael A. Geeves, Leslie A. Leinwand
Pubblicato in: Journal of Biological Chemistry, Numero 294/46, 2019, Pagina/e 17451-17462, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.010563

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Autori: Matthew H. Doran, Elumalai Pavadai, Michael J. Rynkiewicz, Jonathan Walklate, Esther Bullitt, Jeffrey R. Moore, Michael Regnier, Michael A. Geeves, William Lehman
Pubblicato in: Biophysical Journal, Numero 119/4, 2020, Pagina/e 821-830, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2020.07.006

Conference proceedings (17)

Comparison of three U-Net family architectures for left ventricular myocardial wall automatic segmentation.

Autori: Grigoris I Grigoriadis, Maria Roumpi, Dimitrios Zaridis, Vasilis C Pezoulas, Aidonis Rammos, Nikolaos S. Tachos, Katerina K Naka, & Dimitrios I. Fotiadis. (2021, December 9).
Pubblicato in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Numero Dec 2021, 2021, Pagina/e -
Editore: IEEE
DOI: 10.5281/zenodo.6359041

HCM Map: Interactive Knowledge Resource About Molecular Mechanisms of Hypertrophic Cardiomyopathy

Autori: Glavaški Mila; Velicki Lazar
Pubblicato in: Numero 10, 2020
Editore: Zenodo
DOI: 10.5281/zenodo.4293372

BIOMECHANICS OF LEFT VENTRICLE AND IN SILICO DRUG TESTING

Autori: Nenad Filipovic, Bogdan Milicevic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski and Milos Kojic
Pubblicato in: 8th International Congress of the Serbian Society of Mechanics, 2021
Editore: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068845

COUPLED OHARA-RUDY NUMERICAL MODEL FOR HEART ELECTROMECHANICS

Autori: Vladimir Geroski, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic, Nenad Filipovic, Milos Kojic
Pubblicato in: 8th International Congress of the Serbian Society of Mechanics, 2021
Editore: 8th International Congress of the Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068891

LEFT VENTRICLE MODEL GENERATED FROM ECHOCARDIOGRAPHIC DATA

Autori: Bogdan Milicevic, Miljan Milosevic, Vladimir Geroski, Vladimir Simic, Danijela Trifunovic, Nenad Filipovic, Milos Kojic
Pubblicato in: 8th International Congress of the Serbian Society of Mechanics, 2021
Editore: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068847

Towards the development of a unified virtual population model in hypertrophic cardiomyopathy

Autori: Grigoris I. Grigoriadis, Vasileios C. Pezoulas, Maria Roumpi, George Gkois, Nikolaos S. Tachos, Momcilo Prodanovic, Danica Prodanovic, Boban Stojanovic, Srboljub M. Mijailovich, Nenad Filipovic, & Dimitrios I. Fotiadis.
Pubblicato in: 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI), Numero July 2021, 2021, Pagina/e -
Editore: IEEE
DOI: 10.5281/zenodo.6358609

Estimation of Shear Stress Variation in Extracellular Matrix Caused by Duchenne Muscular Dystrophy

Autori: Momcilo Prodanovic; Danica Prodanovic; Boban Stojanovic; Nenad Filipovic; Gordana R. Jovicic; Srboljub M. Mijailovich
Pubblicato in: Crossref, Numero 17, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635402

Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties

Autori: Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves
Pubblicato in: 2019
Editore: bioRxiv

Computational model for simulation of left ventricle behaviour during heart beat

Autori: Miljan Milosevic; Bogdan Milicevic; Vladimir Simic; Vladimir Geroski; Nenad Filipovic; Milos Kojic
Pubblicato in: Crossref, Numero 28, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635417

Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior

Autori: Momcilo Prodanovic; Boban Stojanovic; Danica Prodanovic; Nenad Filipovic; Srboljub M. Mijailovich
Pubblicato in: Crossref, Numero 29, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635428

Generation of virtual patient data for in-silico cardiomyopathies drug development using tree ensembles: a comparative study

Autori: Vasileios C. Pezoulas; Grigorios I. Grigoriadis; Nikolaos S. Tachos; Fausto Barlocco; Iacopo Olivotto; Dimitrios I. Fotiadis
Pubblicato in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Numero July 20-24, 2020, 2020
Editore: IEEE
DOI: 10.5281/zenodo.4050541

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model

Autori: Vladimir Simic; Miljan Milosevic; Igor Saveljic; Bogdan Milicevic; Nenad Filipovic; Milos Kojic
Pubblicato in: Crossref, Numero 14, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635284

FLUID-ELECTRO-MECHANICAL PARAMETRIC MODEL OF THE LEFT VENTRICLE

Autori: Vladimir Simic, Miljan Milosevic, Bogdan Milicevic, Vladimir Geroski, Nenad Filipovic, Milos Kojic
Pubblicato in: 8th International Congress of the Serbian Society of Mechanics, 2021
Editore: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068864

Variational Gaussian Mixture Models with robust Dirichlet concentration priors for virtual population generation in hypertrophic cardiomyopathy: a comparison study.

Autori: Vasileios C. Pezoulas, Grigorios I. Grigoriadis, Nikolaos S. Tachos, Fausto Barlocco, Iacopo Olivotto, & Dimitrios I. Fotiadis. (2021, December 9).
Pubblicato in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Numero Dec 2021, 2021
Editore: IEEE
DOI: 10.5281/zenodo.6358958

Inhibitory potency of Valsartan/Sacubitril drug combination: molecular docking simulations

Autori: Jelena Dorovic Jovanovic; Zoran Markovic; Mihajlo Kokanovic; Nenad Filipovic; Marijana Stanojevic
Pubblicato in: Crossref, Numero 30, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635185

Semi-Automatic Left Ventricle Model Generation

Autori: Bogdan Milicevic; Milian Milosevic; Vladimir Simic; Danijela Trifunovic; Nenad Filipovic; Milos Kojic
Pubblicato in: Crossref, Numero 11, 2021
Editore: IEEE
DOI: 10.1109/bibe52308.2021.9635408

Generation of virtual patients for in silico cardiomyopathies drug development

Autori: Vasileios C. Pezoulas; Nikolaos S. Tachos; Dimitrios I. Fotiadis
Pubblicato in: IEEE BIBE 2019, Numero 28-30 October 2019, 2019
Editore: IEEE
DOI: 10.5281/zenodo.4050523

Book chapters (5)

Composite Smeared Finite Element – Application to Electrical Field

Autori: Vladimir Geroski, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Nenad Filipovic, Milos Kojic
Pubblicato in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numero 11, 2020, Pagina/e 35-43, ISBN 978-3-030-43657-5
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_4

Finite Element Models with Smeared Fields Within Tissue – A Review of the Current Developments

Autori: Milos Kojic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski, Bogdan Milicevic, Arturas Ziemys, Nenad Filipovic
Pubblicato in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numero 11, 2020, Pagina/e 22-34, ISBN 978-3-030-43657-5
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_3

Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs

Autori: Vladimir Simic, Miljan Milosevic, Arturas Ziemys, Milos Kojic
Pubblicato in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numero 11, 2020, Pagina/e 44-52, ISBN 978-3-030-43657-5
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_5

Heart Mechanical Model Based on Holzapfel Experiments

Autori: Milos Kojic, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic
Pubblicato in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numero 11, 2020, Pagina/e 12-21, ISBN 978-3-030-43657-5
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_2

Tuning Cooperativity of Calcium Activation in Cardiac Muscle

Autori: Momcilo Prodanovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Srboljub M. Mijailovich
Pubblicato in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numero 11, 2020, Pagina/e 53-63, ISBN 978-3-030-43657-5
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_6

Other (1)

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

Autori: Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves
Pubblicato in: BioRxiv, 2019
Editore: bioRxiv

Thesis and dissertations (1)

Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC

Autori: Federica Sacco
Pubblicato in: 2019
Editore: Federica Sacco