In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Informacje na temat projektu

SILICOFCM

Identyfikator umowy o grant: 777204

DOI 10.3030/777204

Projekt został zamknięty

Data podpisania przez KE 8 Maja 2018

Data rozpoczęcia 1 Czerwca 2018

Data zakończenia 28 Lutego 2022

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity € 5 507 441,25

Wkład UE € 5 507 441,25

Koordynowany przez

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Serbia

Rezultaty

Documents, reports (11)

SILICOFCM Reference Architecture

Innovative generic approach and reference architecture that will facilitate the deployment of a system for effectiveness in critically ill patientswill be defined designed and documented

SILICOFCM Cloud platform

D12 is the outcome of Task 12 It documents the SILICOFCM Reference Architecture as well as the functional specification of the core architectural components

Protein and cell data

Specific HCMrelated mutations on human cardiac sarcomere Ca2sensitivity mechanics kinetics and energetics using a large sample collection from genotyped HCM patients

Software: Upgrade FE simulation

Finite element programs will be adapted to subject specific data

Road map on Business Model v1

D96 Road map on Business ModelRTech R M12 PUBusiness plan and business model will be developed for our consortium of partners for commercialization of DSS computational platform for cardiomyopathy

Road map on Business Model v4

Road map on Business Model forth version

Road map on Business Model v3

Road map on Business Model third version

Physiological experiments

Basic physiological experiments for heart disease will be conducted

Requirements Analysis

D11 is the outcome of Task 11 documenting the review of the StateoftheArt and the prioritized list of requirements that will be addressed by SILICOFCM

Road map on Business Model v2

Road map on Business Model second version

Imaging acquisition data

Medical images for segmentation of left ventricular LV myocardial will be provided

Other (6)

Interface for drug testing

Interface drug database will be developed interactive uploaddownload applications may also be provided and all connections to the cloud server computational framework will be secured and encrypted

Computational pipelines for drug testing

Computational tools from WP4 WP5 and WP6 in order to simulate all drug testing during development will be integrated

SILICOFCM flyers

The creation and distribution of different flyers for different types of public

Workflow for drug testing

Workflow for computational modelling for basic drug testing for FCM will be defined

Project Website

The project website will be devloped in order to provide all relevant information about the project

Project videos

Project video for both training and dissemination purposes with animations

Publikacje

Peer reviewed articles (55)

Computational Modeling of the Effects of Drugs in HCM and DCM Cardiomyopathies

Autorzy: Mijailovich, S.M., Prodanovic, M., Poggesi, C., Regnier, M., Geeves, M.A.
Opublikowane w: Biophysical Society, 2022, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2021.11.1578

Pathophysiology and Treatment of Hypertrophic Cardiomyopathy: New Perspectives

Autorzy: Zampieri, M., Berteotti, M., Ferrantini, C., Tassetti, L., Gabriele, M., Tomberli, B., Castelli, G., Cappelli, F., Stefàno, P., Marchionni, N., Coppini, R., Olivotto, I.
Opublikowane w: Curr Heart Fail Rep, 2021, ISSN 1546-9530
Wydawca: Current Science Inc.
DOI: 10.1007/s11897-021-00523-0

Alpha and beta myosin isoforms and human atrial and ventricular contraction

Autorzy: Walklate, J., Ferrantini, C., Johnson, C.A., Tesi, C., Poggesi, C., Geeves, M.A.
Opublikowane w: Cell Mol Life Sci, 2021, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-021-03971-y

LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events

Autorzy: Gerhard, E.F., Wang, L., Singh, R., Schueler, S., Genovese, L.D., Woods, A., Tang, D., Smith, N.R., Psotka, M.A., Tovey, S., Desai, S.S., Jakovljevic, D.G., MacGowan, G.A., Shah, P.
Opublikowane w: Journal of Heart and Lung Transplantation, 2021, ISSN 1053-2498
Wydawca: Elsevier BV
DOI: 10.1016/j.healun.2021.08.001

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Autorzy: Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Opublikowane w: JCI Insight, Numer 5/20, 2020, ISSN 2379-3708
Wydawca: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.142446

Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy.

Autorzy: Velicki, L., Jakovljevic, D.G., Preveden, A., Golubovic, M., Bjelobrk, M., Ilic, A., Stojsic, S., Barlocco, F., Tafelmeier, M., Okwose, N., Tesic, M.
Opublikowane w: BMC Cardiovascular Disorders, 2020, ISSN 1471-2261
Wydawca: BioMed Central
DOI: 10.1186/s12872-020-01807-4

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2'-deoxy-ATP

Autorzy: Ma, W., Childers, M., Murray, J., Moussavi-Harami, F., Gong, H., Weiss, R., Daggett, V., Irving, T., Regnier, M.
Opublikowane w: J Physiol, 2020, ISSN 0022-3751
Wydawca: Blackwell Publishing Inc.
DOI: 10.1113/jp280402

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics

Autorzy: Milos Kojic, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Vladimir Geroski, Sara Nizzero, Arturas Ziemys, Nenad Filipovic, Mauro Ferrari
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 7, 2019, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2019.00381

Prognostic value of peak oxygen uptake in patients supported with left ventricular assist devices (PRO-VAD)

Autorzy: Mirza, K.K., Szymanski, M.K., Schmidt, T., de Jonge, N., Brahmbhatt, D.H., Billia, D., Hsu, S., MacGowan, G.A., Jakovljevic, D.G., Agostoni, P., Trombara, F., Jorde, U., Rochlani, Y., Vandersmissen, K., Reiss, N., Russell, S.D., Meyns, M., Gustafsson, F.
Opublikowane w: ACC Heart Fail, 2021, ISSN 2213-1779
Wydawca: Elsevier BV
DOI: 10.1016/j.jchf.2021.05.021

Shared molecular mechanisms of hypertrophic cardiomyopathy and its clinical presentations: automated molecular mechanisms extraction approach

Autorzy: Glavaški, M. and Velicki, L.
Opublikowane w: Life, 2021, ISSN 2075-1729
Wydawca: MDPI
DOI: 10.3390/life11080785

Disease progression of hypertrophic cardiomyopathy: Modeling using machine learning

Autorzy: Pičulin, M., Smole, T., Žunkovič, B., Kokalj, E., Robnik-Šikonja, M., Kukar, M., Fotiadis, D.I., Pezoulas, V.C., Tachos, N.S., Barlocco, F. and Mazzarotto, F.
Opublikowane w: JMIR medical informatics, 2022, ISSN 2291-9694
Wydawca: JMIR Publications
DOI: 10.2196/30483

Humans and machines in biomedical knowledge curation: hypertrophic cardiomyopathy molecular mechanisms’ representation

Autorzy: Glavaški, M., Velicki, L.
Opublikowane w: BioData Mining, 2021, ISSN 1756-0381
Wydawca: BioMed Central
DOI: 10.1186/s13040-021-00279-2

The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle

Autorzy: Giulia Vitale, Cecilia Ferrantini, Nicoletta Piroddi, Beatrice Scellini, Josè Manuel Pioner, Barbara Colombini, Chiara Tesi, Corrado Poggesi
Opublikowane w: Journal of Muscle Research and Cell Motility, 2019, ISSN 0142-4319
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10974-019-09566-2

Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy

Autorzy: Maria Tafelmeier, Andrea Baessler, Stefan Wagner, Bernhard Unsoeld, Andrej Preveden, Fausto Barlocco, Alessia Tomberli, Dejana Popovic, Paul Brennan, Guy A. MacGowan, Arsen Ristic, Lazar Velicki, Iacopo Olivotto, Djordje G. Jakovljevic, Lars S. Maier
Opublikowane w: Clinical Cardiology, Numer 43/5, 2020, Strona(/y) 430-440, ISSN 0160-9289
Wydawca: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23346

The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions

Autorzy: Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Opublikowane w: Journal of Molecular and Cellular Cardiology, Numer 155, 2021, Strona(/y) 112-124, ISSN 0022-2828
Wydawca: Academic Press
DOI: 10.1016/j.yjmcc.2021.02.009

Multiscale modeling of twitch contractions in cardiac trabeculae

Autorzy: Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Michael A. Geeves, Michael Regnier
Opublikowane w: Journal of General Physiology, Numer 153/3, 2021, ISSN 0022-1295
Wydawca: Rockefeller University Press
DOI: 10.1085/jgp.202012604

Ventricular arrhythmias not meeting criteria for terminating cardiopulmonary exercise testing stratify prognosis and disease severity in heart failure of preserved, midrange, and reduced ejection fraction

Autorzy: Dejana Popovic, Ross Arena, Djordje Jakovljevic, Arsen Ristic, Marco Guazzi
Opublikowane w: Clinical Cardiology, Numer 43/7, 2020, Strona(/y) 698-705, ISSN 0160-9289
Wydawca: Clinical Cardiology Publishing Company, Inc.
DOI: 10.1002/clc.23367

Feasibility of the cardiac output response to stress test in suspected heart failure patients

Autorzy: Charman SJ, Okwose NC, Taylor CJ, Bailey K, Fuat A, Ristic A, Mant J, Deaton C, Seferovic PM, Coats AJS, Hobbs FDR, MacGowan GA, Jakovljevic DG.
Opublikowane w: Family Practice, 2022, ISSN 0263-2136
Wydawca: Oxford University Press
DOI: 10.1093/fampra/cmab184

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy

Autorzy: Josè Manuel Pioner, Alessandra Fornaro, Raffaele Coppini, Nicole Ceschia, Leonardo Sacconi, Maria Alice Donati, Silvia Favilli, Corrado Poggesi, Iacopo Olivotto, Cecilia Ferrantini
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00368

T-tubule remodeling in human hypertrophic cardiomyopathy.

Autorzy: Vitale G, Coppini R, Tesi C, Poggesi C, Sacconi L, Ferrantini C
Opublikowane w: J Muscle Res Cell Motil, Numer 42 (2), 2021, ISSN 1573-2657
Wydawca: Springer
DOI: 10.1007/s10974-020-09591-6

A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy

Autorzy: Tim Smole, Bojan Žunkovič, Matej Pičulin, Enja Kokalj, Marko Robnik-Šikonja, Matjaž Kukar, Dimitrios I Fotiadis, Vasileios C Pezoulas, Nikolaos S Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S Maier, Lazar Velicki, Guy A MacGowan, Iacopo Olivotto, Nenad Filipović, Djordje G Jakovljević, Zoran Bosnić
Opublikowane w: Computers in Biology and Medicine, 2021, ISSN 0010-4825
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104648

Computational model for heart tissue with direct use of experimental constitutive relationships

Autorzy: Kojic, M., Milosevic, M., Milicevic, B., Geroski, V., Simic, V., Trifunovic, D., Stankovic, G., Filipovic, N.
Opublikowane w: Journal of the Serbian Society for Computational Mechanics, 2021, ISSN 1820-6530
Wydawca: The Serbian Society for Computational Mechanics (SSCM)
DOI: 10.24874/jsscm.2021.15.01.01

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

Autorzy: Prodanovic, M., Geeves, M.A., Poggesi, C., Regnier, M., Mijailovich, S.M.
Opublikowane w: Int. J. Mol. Sci, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031135

Gender Related Differences in the Clinical Presentation of Hypertrophic Cardiomyopathy—An Analysis from the SILICOFCM Database

Autorzy: Preveden, A., Golubovic, M., Bjelobrk, M., Miljkovic, T., Ilic, A., Stojsic, S., Gajic, D., Glavaski, M., Maier, L.S., Okwose, N. and Popovic, D.
Opublikowane w: Medicina, 2022, ISSN 1010-660X
Wydawca: Lietuvos Gydytoju Sajunga
DOI: 10.3390/medicina58020314

Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study

Autorzy: Nduka C. Okwose, Leah Avery, Nicola O’Brien, Sophie Cassidy, Sarah J. Charman, Kristian Bailey, Lazar Velicki, Iacopo Olivotto, Paul Brennan, Guy A. MacGowan, Djordje G. Jakovljevic
Opublikowane w: Sports Medicine - Open, Numer 5/1, 2019, ISSN 2199-1170
Wydawca: Springer
DOI: 10.1186/s40798-019-0216-x

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Autorzy: Filomena, M.C., Yamamoto, D.L., Carullo, P., Medvedev, R., Ghisleni, A., Piroddi, N., Scellini, B., Crispino, R., D'Autilia, F., Zhang, J., Felicetta, A., Nemska, S., Serio, S., Tesi, C., Catalucci, D., Linke, W.A., Polishchuk, R., Poggesi, C., Gautel, M., Bang, M.L.
Opublikowane w: Elife, 2021, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.58313

The effect of age on mechanisms of exercise tolerance: reduced arteriovenous oxygen difference causes lower oxygen consumption in older people

Autorzy: Fuller, A., Okwose, N., Scragg, J., Eggett, C., Luke, P., Bandali, A., Velicki, R., Greaves, L., MacGowan, GA,, Jakovljevic, DG.
Opublikowane w: Experimental Gerontology, 2021, ISSN 0531-5565
Wydawca: Elsevier BV
DOI: 10.1016/j.exger.2021.111340

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

Autorzy: Karin P. Hammer, Julian Mustroph, Teresa Stauber, Walter Birchmeier, Stefan Wagner, Lars S. Maier
Opublikowane w: PLOS ONE, Numer 16/6, 2021, Strona(/y) e0252649, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0252649

A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Autorzy: Vasileios C. Pezoulas; Grigoris I. Grigoriadis; George Gkois; Nikolaos S. Tachos; Tim Smole; Zoran Bosnić; Matej Pičulin; Iacopo Olivotto; Fausto Barlocco; Marko Robnik-Šikonja; Djordje G. Jakovljevic; Andreas V. Goules; Athanasios G. Tzioufas; Dimitrios I. Fotiadis
Opublikowane w: Computers in Biology and Medicine, Numer 10, 2021, ISSN 0010-4825
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104520

Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

Autorzy: Miljan Milosevic, Dusica B. Stojanovic, Vladimir Simic, Mirjana Grkovic, Milos Bjelovic, Petar S. Uskokovic, Milos Kojic
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-68117-9

NT‐proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure

Autorzy: Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Opublikowane w: ESC Heart Failure, Numer 6/2, 2019, Strona(/y) 449-454, ISSN 2055-5822
Wydawca: Wiley Online Library
DOI: 10.1002/ehf2.12424

A Computational Model for Drug Release from PLGA Implant

Autorzy: Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic
Opublikowane w: Materials, Numer 11/12, 2018, Strona(/y) 2416, ISSN 1996-1944
Wydawca: MDPI Open Access Publishing
DOI: 10.3390/ma11122416

Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock

Autorzy: Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas Müller, Lars S. Maier
Opublikowane w: Circulation: Cardiovascular Interventions, Numer 12/2, 2019, ISSN 1941-7640
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circinterventions.118.007425

Association between heart rate variability and haemodynamic response to exercise in chronic heart failure

Autorzy: Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
Opublikowane w: Scandinavian Cardiovascular Journal, Numer 53/2, 2019, Strona(/y) 77-82, ISSN 1401-7431
Wydawca: Taylor & Francis
DOI: 10.1080/14017431.2019.1590629

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue

Autorzy: M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari
Opublikowane w: Computers in Biology and Medicine, Numer 108, 2019, Strona(/y) 288-304, ISSN 0010-4825
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2019.03.023

Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments

Autorzy: Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier
Opublikowane w: Biophysical Journal, Numer 116/3, 2019, Strona(/y) 116a, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.654

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Autorzy: Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier
Opublikowane w: The Journal of General Physiology, Numer 151/5, 2019, Strona(/y) 680-704, ISSN 0022-1295
Wydawca: Rockefeller University Press
DOI: 10.1085/jgp.201812165

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Autorzy: Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
Opublikowane w: The Journal of General Physiology, Numer 151/1, 2019, Strona(/y) 18-29, ISSN 0022-1295
Wydawca: Rockefeller University Press
DOI: 10.1085/jgp.201812160

Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients

Autorzy: Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi
Opublikowane w: Biophysical Journal, Numer 116/3, 2019, Strona(/y) 29a, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.198

A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins

Autorzy: J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves
Opublikowane w: Analytical Biochemistry, Numer 581, 2019, Strona(/y) 113338, ISSN 0003-2697
Wydawca: Academic Press
DOI: 10.1016/j.ab.2019.06.009

Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study

Autorzy: Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M Seferović, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic
Opublikowane w: BMJ Open, Numer 9/4, 2019, Strona(/y) e028122, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-028122

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging

Autorzy: Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard
Opublikowane w: Biophysical Journal, 2019, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2019.06.026

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Autorzy: Raffaele Coppini, Cecilia Ferrantini, Josè Manuel Pioner, Lorenzo Santini, Zhinuo J. Wang, Chiara Palandri, Marina Scardigli, Giulia Vitale, Leonardo Sacconi, Pierluigi Stefàno, Laura Flink, Katherine Riedy, Francesco Saverio Pavone, Elisabetta Cerbai, Corrado Poggesi, Alessandro Mugelli, Alfonso Bueno-Orovio, Iacopo Olivotto, Mark V. Sherrid
Opublikowane w: JACC: Basic to Translational Science, Numer 4/7, 2019, Strona(/y) 795-813, ISSN 2452-302X
Wydawca: American College of Cardiology
DOI: 10.1016/j.jacbts.2019.06.004

Prognostic Value of NT-Pro Brain Natriuretic Peptide During Exercise Recovery in Ischemic Heart Failure of Reduced, Midrange, and Preserved Ejection Fraction

Autorzy: Djordjevic T, Arena R, Guazzi M, Popovic D.
Opublikowane w: J Cardiopulm Rehabil Prev, 2021, ISSN 1932-7501
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hcr.0000000000000531

Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic deformation

Autorzy: Boban Stojanovic, Marina Svicevic, Ana Kaplarevic-Malisic, Richard J. Gilbert, Srboljub M. Mijailovich
Opublikowane w: Journal of Computational Science, Numer 39, 2020, Strona(/y) 101062, ISSN 1877-7503
Wydawca: Elsevier BV
DOI: 10.1016/j.jocs.2019.101062

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Autorzy: Sarah J. Charman, Lazar Velicki, Nduka C. Okwose, Amy Harwood, Gordon McGregor, Arsen Ristic, Prithwish Banerjee, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic
Opublikowane w: ESC Heart Failure, Numer 8/1, 2021, Strona(/y) 175-182, ISSN 2055-5822
Wydawca: European Society of Cardiology
DOI: 10.1002/ehf2.13061

Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data

Autorzy: Srboljub M. Mijailovich, Momcilo Prodanovic, Thomas C. Irving
Opublikowane w: International Journal of Molecular Sciences, Numer 20/23, 2019, Strona(/y) 6044, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20236044

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

Autorzy: Matthew Carter Childers, Michael Geeves, Valerie Daggett, Michael Regnier
Opublikowane w: Archives of Biochemistry and Biophysics, Numer 699, 2021, Strona(/y) 108733, ISSN 0003-9861
Wydawca: Academic Press
DOI: 10.1016/j.abb.2020.108733

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Autorzy: Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Opublikowane w: International Journal of Molecular Sciences, Numer 20/15, 2019, Strona(/y) 3799, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20153799

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Autorzy: Walklate J, Kao K, Regnier M, Geeves MA.
Opublikowane w: J Biol Chem, 2022, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101640

Identification of sequence changes in myosin II that adjust muscle contraction velocity

Autorzy: Chloe A. Johnson, Jake E. McGreig, Sarah T. Jeanfavre, Jonathan Walklate, Carlos D. Vera, Marta Farré, Daniel P. Mulvihill, Anthony J. Baines, Martin Ridout, Leslie A. Leinwand, Mark N. Wass, Michael A. Geeves
Opublikowane w: PLOS Biology, Numer 19/6, 2021, Strona(/y) e3001248, ISSN 1545-7885
Wydawca: PLOS
DOI: 10.1371/journal.pbio.3001248

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Autorzy: Francesco Mazzarotto, Iacopo Olivotto, Beatrice Boschi, Francesca Girolami, Corrado Poggesi, Paul J. R. Barton, Roddy Walsh
Opublikowane w: Journal of the American Heart Association, Numer 9/8, 2020, ISSN 2047-9980
Wydawca: Wiley-Blackwell
DOI: 10.1161/jaha.119.015473

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Autorzy: Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Giulia Vitale, Josè Manuel Pioner, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi
Opublikowane w: Journal of General Physiology, Numer 153/7, 2021, ISSN 0022-1295
Wydawca: Rockefeller University Press
DOI: 10.1085/jgp.202012789

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Autorzy: Carlos D. Vera, Chloe A. Johnson, Jonathan Walklate, Arjun Adhikari, Marina Svicevic, Srboljub M. Mijailovich, Ariana C. Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Michael A. Geeves, Leslie A. Leinwand
Opublikowane w: Journal of Biological Chemistry, Numer 294/46, 2019, Strona(/y) 17451-17462, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.010563

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Autorzy: Matthew H. Doran, Elumalai Pavadai, Michael J. Rynkiewicz, Jonathan Walklate, Esther Bullitt, Jeffrey R. Moore, Michael Regnier, Michael A. Geeves, William Lehman
Opublikowane w: Biophysical Journal, Numer 119/4, 2020, Strona(/y) 821-830, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2020.07.006

Conference proceedings (17)

Comparison of three U-Net family architectures for left ventricular myocardial wall automatic segmentation.

Autorzy: Grigoris I Grigoriadis, Maria Roumpi, Dimitrios Zaridis, Vasilis C Pezoulas, Aidonis Rammos, Nikolaos S. Tachos, Katerina K Naka, & Dimitrios I. Fotiadis. (2021, December 9).
Opublikowane w: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Numer Dec 2021, 2021, Strona(/y) -
Wydawca: IEEE
DOI: 10.5281/zenodo.6359041

HCM Map: Interactive Knowledge Resource About Molecular Mechanisms of Hypertrophic Cardiomyopathy

Autorzy: Glavaški Mila; Velicki Lazar
Opublikowane w: Numer 10, 2020
Wydawca: Zenodo
DOI: 10.5281/zenodo.4293372

BIOMECHANICS OF LEFT VENTRICLE AND IN SILICO DRUG TESTING

Autorzy: Nenad Filipovic, Bogdan Milicevic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski and Milos Kojic
Opublikowane w: 8th International Congress of the Serbian Society of Mechanics, 2021
Wydawca: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068845

COUPLED OHARA-RUDY NUMERICAL MODEL FOR HEART ELECTROMECHANICS

Autorzy: Vladimir Geroski, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic, Nenad Filipovic, Milos Kojic
Opublikowane w: 8th International Congress of the Serbian Society of Mechanics, 2021
Wydawca: 8th International Congress of the Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068891

LEFT VENTRICLE MODEL GENERATED FROM ECHOCARDIOGRAPHIC DATA

Autorzy: Bogdan Milicevic, Miljan Milosevic, Vladimir Geroski, Vladimir Simic, Danijela Trifunovic, Nenad Filipovic, Milos Kojic
Opublikowane w: 8th International Congress of the Serbian Society of Mechanics, 2021
Wydawca: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068847

Towards the development of a unified virtual population model in hypertrophic cardiomyopathy

Autorzy: Grigoris I. Grigoriadis, Vasileios C. Pezoulas, Maria Roumpi, George Gkois, Nikolaos S. Tachos, Momcilo Prodanovic, Danica Prodanovic, Boban Stojanovic, Srboljub M. Mijailovich, Nenad Filipovic, & Dimitrios I. Fotiadis.
Opublikowane w: 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI), Numer July 2021, 2021, Strona(/y) -
Wydawca: IEEE
DOI: 10.5281/zenodo.6358609

Estimation of Shear Stress Variation in Extracellular Matrix Caused by Duchenne Muscular Dystrophy

Autorzy: Momcilo Prodanovic; Danica Prodanovic; Boban Stojanovic; Nenad Filipovic; Gordana R. Jovicic; Srboljub M. Mijailovich
Opublikowane w: Crossref, Numer 17, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635402

Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties

Autorzy: Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves
Opublikowane w: 2019
Wydawca: bioRxiv

Computational model for simulation of left ventricle behaviour during heart beat

Autorzy: Miljan Milosevic; Bogdan Milicevic; Vladimir Simic; Vladimir Geroski; Nenad Filipovic; Milos Kojic
Opublikowane w: Crossref, Numer 28, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635417

Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior

Autorzy: Momcilo Prodanovic; Boban Stojanovic; Danica Prodanovic; Nenad Filipovic; Srboljub M. Mijailovich
Opublikowane w: Crossref, Numer 29, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635428

Generation of virtual patient data for in-silico cardiomyopathies drug development using tree ensembles: a comparative study

Autorzy: Vasileios C. Pezoulas; Grigorios I. Grigoriadis; Nikolaos S. Tachos; Fausto Barlocco; Iacopo Olivotto; Dimitrios I. Fotiadis
Opublikowane w: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Numer July 20-24, 2020, 2020
Wydawca: IEEE
DOI: 10.5281/zenodo.4050541

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model

Autorzy: Vladimir Simic; Miljan Milosevic; Igor Saveljic; Bogdan Milicevic; Nenad Filipovic; Milos Kojic
Opublikowane w: Crossref, Numer 14, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635284

FLUID-ELECTRO-MECHANICAL PARAMETRIC MODEL OF THE LEFT VENTRICLE

Autorzy: Vladimir Simic, Miljan Milosevic, Bogdan Milicevic, Vladimir Geroski, Nenad Filipovic, Milos Kojic
Opublikowane w: 8th International Congress of the Serbian Society of Mechanics, 2021
Wydawca: Serbian Society of Mechanics
DOI: 10.5281/zenodo.5068864

Variational Gaussian Mixture Models with robust Dirichlet concentration priors for virtual population generation in hypertrophic cardiomyopathy: a comparison study.

Autorzy: Vasileios C. Pezoulas, Grigorios I. Grigoriadis, Nikolaos S. Tachos, Fausto Barlocco, Iacopo Olivotto, & Dimitrios I. Fotiadis. (2021, December 9).
Opublikowane w: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Numer Dec 2021, 2021
Wydawca: IEEE
DOI: 10.5281/zenodo.6358958

Inhibitory potency of Valsartan/Sacubitril drug combination: molecular docking simulations

Autorzy: Jelena Dorovic Jovanovic; Zoran Markovic; Mihajlo Kokanovic; Nenad Filipovic; Marijana Stanojevic
Opublikowane w: Crossref, Numer 30, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635185

Semi-Automatic Left Ventricle Model Generation

Autorzy: Bogdan Milicevic; Milian Milosevic; Vladimir Simic; Danijela Trifunovic; Nenad Filipovic; Milos Kojic
Opublikowane w: Crossref, Numer 11, 2021
Wydawca: IEEE
DOI: 10.1109/bibe52308.2021.9635408

Generation of virtual patients for in silico cardiomyopathies drug development

Autorzy: Vasileios C. Pezoulas; Nikolaos S. Tachos; Dimitrios I. Fotiadis
Opublikowane w: IEEE BIBE 2019, Numer 28-30 October 2019, 2019
Wydawca: IEEE
DOI: 10.5281/zenodo.4050523

Book chapters (5)

Composite Smeared Finite Element – Application to Electrical Field

Autorzy: Vladimir Geroski, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Nenad Filipovic, Milos Kojic
Opublikowane w: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numer 11, 2020, Strona(/y) 35-43, ISBN 978-3-030-43657-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_4

Finite Element Models with Smeared Fields Within Tissue – A Review of the Current Developments

Autorzy: Milos Kojic, Miljan Milosevic, Vladimir Simic, Vladimir Geroski, Bogdan Milicevic, Arturas Ziemys, Nenad Filipovic
Opublikowane w: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numer 11, 2020, Strona(/y) 22-34, ISBN 978-3-030-43657-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_3

Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs

Autorzy: Vladimir Simic, Miljan Milosevic, Arturas Ziemys, Milos Kojic
Opublikowane w: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numer 11, 2020, Strona(/y) 44-52, ISBN 978-3-030-43657-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_5

Heart Mechanical Model Based on Holzapfel Experiments

Autorzy: Milos Kojic, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic
Opublikowane w: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numer 11, 2020, Strona(/y) 12-21, ISBN 978-3-030-43657-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_2

Tuning Cooperativity of Calcium Activation in Cardiac Muscle

Autorzy: Momcilo Prodanovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Srboljub M. Mijailovich
Opublikowane w: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Numer 11, 2020, Strona(/y) 53-63, ISBN 978-3-030-43657-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-43658-2_6

Other (1)

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

Autorzy: Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves
Opublikowane w: BioRxiv, 2019
Wydawca: bioRxiv

Thesis and dissertations (1)

Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC

Autorzy: Federica Sacco
Opublikowane w: 2019
Wydawca: Federica Sacco