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Hypoglycaemia - REdefining SOLutions for better liVEs

Objective

Diabetes is one of the most prevalent global non-communicable diseases, affecting 60 million people in Europe, 10% of whom with type 1 diabetes. Normalising elevated glucose levels decreases symptoms, prevents microvascular complications, improves cardiovascular health and saves lives, but creates a significant risk for hypoglycaemia when insulin treatment is required. Hypoglycaemia is a serious event associated with cognitive decline, reduced quality of life, cardiovascular events and mortality. Hypoglycaemia remains the principal barrier to achieve glucose levels necessary to prevent diabetic complications of chronic hyperglycaemia.
The overall objective of Hypo-RESOLVE is to alleviate the burden and consequences of hypoglycaemia, to be achieved by answering several key questions through a unique public-private partnership. Hypo-RESOLVE will construct secure sustainable databases with data from 100-150 clinical trials offering huge statistical power to establish the glucose threshold(s) below which hypoglycaemia constitutes a risk for poor outcomes in various populations. This will provide valuable input for an evidence based classification of hypoglycaemia to be adopted by regulators, patient organisations and other stakeholders, for application in future trials, the clinic and epidemiologic studies. The basic science and translational research line of Hypo-RESOLVE will advance our understanding on mechanisms underlying consequences of hypoglycaemia and explore novel pathways for the restoration of impaired awareness of hypoglycaemia. Finally, we will determine the significance of CGM-detected low glucose and investigate psychological and economic impacts of hypoglycaemia to quantify the burden of hypoglycaemia both for the individual and next-of-kin, as well as for society.
Altogether, Hypo-RESOLVE will importantly further our knowledge of hypoglycaemia, (facilitate to) reduce its burden and contribute to a better life for patients with insulin-treated diabetes

Call for proposal

H2020-JTI-IMI2-2016-10-two-stage
See other projects for this call

Coordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 282 965,99

Participants (23)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 420 978,75
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 780 982,50
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 661 202,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
EU contribution
€ 445 981,88
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
Activity type
Research Organisations
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 1 354 981,25
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 955 601,25
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 1 971 491,75
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 1 011 732,50
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 383 622,50
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 502 125
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
EU contribution
€ 934 250
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 392 687,50
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 351 453,75
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
NOVO NORDISK A/S
Denmark
EU contribution
€ 0
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELI LILLY AND COMPANY LTD
United Kingdom
EU contribution
€ 0
Address
Lilly House Basingview
RG21 4FA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS DEUTSCHLAND GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ABBOTT DIABETES CARE
United States
EU contribution
€ 0
Address
1360 South Loop Rd 1420 Harbor Bay Parkway
94502 Alameda
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDTRONIC INTERNATIONAL TRADING SARL
Switzerland
EU contribution
€ 0
Address
Route Du Molliau 31
1131 Tolochenaz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JDRF INTERNATIONAL
United States
EU contribution
€ 0
Address
26 Broadway 14Th Floor
10004 New York
Activity type
Research Organisations
FEDERATION INTERNATIONALE DU DIABETE
Belgium
EU contribution
€ 0
Address
Chaussee De La Hulpe 166
1170 Bruxelles
Activity type
Other
UNITIO INC
United States
EU contribution
€ 0
Address
11 Avenue De Lafayette 5Th Floor
02111 Boston
Activity type
Research Organisations
THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST
United States
EU contribution
€ 0
Address
230 Park Avenue Suite 659
10169 New York
Activity type
Other
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 0
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments