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Hypoglycaemia - REdefining SOLutions for better liVEs

Objective

Diabetes is one of the most prevalent global non-communicable diseases, affecting 60 million people in Europe, 10% of whom with type 1 diabetes. Normalising elevated glucose levels decreases symptoms, prevents microvascular complications, improves cardiovascular health and saves lives, but creates a significant risk for hypoglycaemia when insulin treatment is required. Hypoglycaemia is a serious event associated with cognitive decline, reduced quality of life, cardiovascular events and mortality. Hypoglycaemia remains the principal barrier to achieve glucose levels necessary to prevent diabetic complications of chronic hyperglycaemia.
The overall objective of Hypo-RESOLVE is to alleviate the burden and consequences of hypoglycaemia, to be achieved by answering several key questions through a unique public-private partnership. Hypo-RESOLVE will construct secure sustainable databases with data from 100-150 clinical trials offering huge statistical power to establish the glucose threshold(s) below which hypoglycaemia constitutes a risk for poor outcomes in various populations. This will provide valuable input for an evidence based classification of hypoglycaemia to be adopted by regulators, patient organisations and other stakeholders, for application in future trials, the clinic and epidemiologic studies. The basic science and translational research line of Hypo-RESOLVE will advance our understanding on mechanisms underlying consequences of hypoglycaemia and explore novel pathways for the restoration of impaired awareness of hypoglycaemia. Finally, we will determine the significance of CGM-detected low glucose and investigate psychological and economic impacts of hypoglycaemia to quantify the burden of hypoglycaemia both for the individual and next-of-kin, as well as for society.
Altogether, Hypo-RESOLVE will importantly further our knowledge of hypoglycaemia, (facilitate to) reduce its burden and contribute to a better life for patients with insulin-treated diabetes

Coordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Net EU contribution
€ 2 281 124,81
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 565 996,04

Participants (26)

KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 385 702,50
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 077 672,51
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
Net EU contribution
€ 780 982,50
Address
Neue Stiftingtalstrasse 6
8010 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Higher or Secondary Education Establishments
Other funding
€ 65 127,50
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 661 202,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 638 191,25
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
Net EU contribution
€ 445 981,88
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Research Organisations
Other funding
€ 6 127,50
SYDDANSK UNIVERSITET
Denmark
Net EU contribution
€ 1 354 981,25
Address
Campusvej 55
5230 Odense M

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Region
Danmark Syddanmark Fyn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 438 784,38
UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 955 601,25
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 77 000,00
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 1 912 578,70
Address
Firth Court Western Bank
S10 2TN Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Other funding
€ 301 327,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST
United Kingdom
Net EU contribution
€ 58 913,05
Address
Beech Hill Road 8
S10 2SB Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Research Organisations
Other funding
€ 0,00
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 1 011 732,50
Address
Kongens Vaenge 2
3400 Hillerod

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 131 451,88
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 383 622,50
Address
Nethergate
DD1 4HN Dundee

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Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 928 162,14
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Net EU contribution
€ 502 125,00
Address
Heinrich-hertz-allee 1
66386 St Ingbert

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarpfalz-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 194 810,63
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
Net EU contribution
€ 934 250,00
Address
Rue Michel Servet 1 Cmu
1206 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Research Organisations
Other funding
€ 150 894,38
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Net EU contribution
€ 392 687,50
Address
Via 8 Febbraio 2
35122 Padova

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Other funding
€ 77 687,50
THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 1 351 453,75
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Other funding
€ 253 158,75
NOVO NORDISK A/S
Denmark
Net EU contribution
€ 0,00
Address
Novo Alle 1
2880 Bagsvaerd

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 3 527 454,74
ELI LILLY AND COMPANY LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Region
South East (England) Hampshire and Isle of Wight North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 250 000,00
SANOFI-AVENTIS DEUTSCHLAND GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 723 000,00
ABBOTT DIABETES CARE
United States
Net EU contribution
€ 0,00
Address
1360 South Loop Rd 1420 Harbor Bay Parkway
94502 Alameda

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 250 000,00
MEDTRONIC INTERNATIONAL TRADING SARL
Switzerland
Net EU contribution
€ 0,00
Address
Route Du Molliau 31
1131 Tolochenaz

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 162 000,00
JDRF INTERNATIONAL
United States
Net EU contribution
€ 0,00
Address
26 Broadway 14th Floor
10004 New York

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Activity type
Research Organisations
Other funding
€ 238 000,00
FEDERATION INTERNATIONALE DU DIABETE
Belgium
Net EU contribution
€ 0,00
Address
Chaussee De La Hulpe 166
1170 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 82 462,00
UNITIO INC
United States
Net EU contribution
€ 0,00
Address
11 Avenue De Lafayette 5th Floor
02111 Boston

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Activity type
Research Organisations
Other funding
€ 132 563,00
THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST
United States
Net EU contribution
€ 0,00
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Houtlaan 4
6525 XZ Nijmegen
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY OF LEICESTER
United Kingdom
Net EU contribution
€ 35 276,25
Address
University Road
LE1 7RH Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST
United Kingdom
Net EU contribution
€ 1 841,18
Address
Infirmary Square Leicester Royal Infirmary Balmoral Building Level 3
LE1 5WW Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 52 654,18