CORDIS
EU research results

CORDIS

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Hypoglycaemia - REdefining SOLutions for better liVEs

Project information

Grant agreement ID: 777460

Status

Ongoing project

  • Start date

    1 May 2018

  • End date

    30 April 2022

Funded under:

H2020-EU.3.1.7.

  • Overall budget:

    € 26 774 582,50

  • EU contribution

    € 13 450 057,12

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Objective

Diabetes is one of the most prevalent global non-communicable diseases, affecting 60 million people in Europe, 10% of whom with type 1 diabetes. Normalising elevated glucose levels decreases symptoms, prevents microvascular complications, improves cardiovascular health and saves lives, but creates a significant risk for hypoglycaemia when insulin treatment is required. Hypoglycaemia is a serious event associated with cognitive decline, reduced quality of life, cardiovascular events and mortality. Hypoglycaemia remains the principal barrier to achieve glucose levels necessary to prevent diabetic complications of chronic hyperglycaemia.
The overall objective of Hypo-RESOLVE is to alleviate the burden and consequences of hypoglycaemia, to be achieved by answering several key questions through a unique public-private partnership. Hypo-RESOLVE will construct secure sustainable databases with data from 100-150 clinical trials offering huge statistical power to establish the glucose threshold(s) below which hypoglycaemia constitutes a risk for poor outcomes in various populations. This will provide valuable input for an evidence based classification of hypoglycaemia to be adopted by regulators, patient organisations and other stakeholders, for application in future trials, the clinic and epidemiologic studies. The basic science and translational research line of Hypo-RESOLVE will advance our understanding on mechanisms underlying consequences of hypoglycaemia and explore novel pathways for the restoration of impaired awareness of hypoglycaemia. Finally, we will determine the significance of CGM-detected low glucose and investigate psychological and economic impacts of hypoglycaemia to quantify the burden of hypoglycaemia both for the individual and next-of-kin, as well as for society.
Altogether, Hypo-RESOLVE will importantly further our knowledge of hypoglycaemia, (facilitate to) reduce its burden and contribute to a better life for patients with insulin-treated diabetes
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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 301 983,37

Participants (22)

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 325 891,25

MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 800 000

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 661 202,50

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER

France

EU Contribution

€ 465 000

SYDDANSK UNIVERSITET

Denmark

EU Contribution

€ 1 354 981,25

UNIVERSITE DE LAUSANNE

Switzerland

EU Contribution

€ 955 601,25

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 1 990 508,75

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 1 030 750

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 383 622,50

EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

Germany

EU Contribution

€ 502 125

SIB INSTITUT SUISSE DE BIOINFORMATIQUE

Switzerland

EU Contribution

€ 934 250

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

EU Contribution

€ 392 687,50

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 1 351 453,75

NOVO NORDISK A/S

Denmark

Eli Lilly and Company Limited

United Kingdom

SANOFI-AVENTIS DEUTSCHLAND GMBH

Germany

ABBOTT DIABETES CARE

United States

MEDTRONIC INTERNATIONAL TRADING SARL

Switzerland

JDRF INTERNATIONAL

United States

FEDERATION INTERNATIONALE DU DIABETE

Belgium

UNITIO INC

United States

THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST

United States

Project information

Grant agreement ID: 777460

Status

Ongoing project

  • Start date

    1 May 2018

  • End date

    30 April 2022

Funded under:

H2020-EU.3.1.7.

  • Overall budget:

    € 26 774 582,50

  • EU contribution

    € 13 450 057,12

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands