Obiettivo Infertility is a worldwide problem affecting the cattle industry. After successful insemination, embryonic and foetal mortality take place in about 50% of the cases, with most of these losses occurring before implantation. Due to beef and dairy constituting 20.8% of the EU agricultural output, reproductive inefficiency translates into a tremendous social and bioeconomic impact. Although many factors can be involved in preimplantation loss, there is increasing evidence for the role of the maternal immune system and its regulation by seminal plasma (SP). Studies in rodents, humans and pigs have described beneficial effects of SP in improving embryo development and implantation. However, evidence for a role of SP in fertility in cattle, where removal of SP before artificial insemination is routine, is relatively weak. Thus, this project will use a model of heifers mated to vasectomised or intact bulls, to study the role of SP in paternal-maternal communication as it pertains to embryo development and immune modulation. To accomplish this task, a talented Fellow will join a leading laboratory in male reproductive physiology where she will build on her existing skills and acquire new multidisciplinary competencies. An ambitious, yet realistic, work plan has been designed based on the excellent background of the Fellow and the training she will receive, the expertise of the supervisor in male reproductive physiology, and the infrastructure within the host lab for conducting all the experiments with the most appropriate tools. This will ensure that the Fellow completes the scientific objectives of the proposal, communicate and disseminate the results to the scientific and general public, while acquiring a new set of skills that will have a dramatic impact in her career development. If the beneficial effects of SP on fertility is recapitulated in cattle, the associated increased production and efficiency could have a tremendous impact in the beef and dairy industries. Campo scientifico medical and health sciencesclinical medicineandrologyagricultural sciencesanimal and dairy sciencedairymedical and health sciencesbasic medicinephysiologyagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandrymedical and health sciencesclinical medicineembryology Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2017 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2017 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore UNIVERSITAT DE GIRONA Contribution nette de l'UE € 170 121,60 Indirizzo PLACA SANT DOMENEC 3 17004 Girona Spagna Mostra sulla mappa Regione Este Cataluña Girona Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 170 121,60