Deliverables Websites, patent fillings, videos etc. (2) Movie - demonstration Movie demonstration External website of iFermenter External website of iFermenter open to the public, but also has secured login intranet pages to share secure internal information Documents, reports (3) Initial Environmental impact assessment Environmental impact assessment of the new strain, successfully demonstrating 20% reduction of CO2 in milliscales laboratory conditions Developed (reduced) 3 models for the levels Developed reduced 3 models for the levels genome metabolic and process Model predictions have satisfactory error margins 25 when compared to data D32 D34 D36 Successful demonstration of 20% reduction in CO2 footprint from the upscaled industrial process, by an LCA report Successful demonstration of 20 reduction in CO2 footprint from the upscaled industrial process by an LCA report Environmental and demonstrating potential costs of upscaling the process O4b Other (3) Metabolic model, describing different physiological states of the cell factories Metabolic model describing different physiological states of the cell factories Genome network reduced dynamic mode Genome network reduced dynamic mode Process level reduced dynamic model Process level reduced dynamic model Publications Peer reviewed articles (18) Recombinant production of the lantibiotic nisin using <i>Corynebacterium glutamicum</i> in a two-step process Author(s): Dominik Weixler; Max Berghoff; Kirill V. Ovchinnikov; Sebastian Reich; Oliver Goldbeck; Gerd M. Seibold; Christoph Wittmann; Nadav S. Bar; Bernhard J. Eikmanns; Dzung B. Diep; Christian U. Riedel Published in: Microbial Cell Factories, 1, 2022, ISSN 1475-2859 Publisher: BioMed Central DOI: 10.1186/s12934-022-01739-y Sensor fusion based on Extended and Unscented Kalman Filter for bioprocess monitoring Author(s): Andrea Tuveri; Fernando Pérez-García; Pedro A. Lira-Parada; Lars Imsland; Nadav Bar Published in: Journal of Process Control, 2, 2021, ISSN 0959-1524 Publisher: Butterworth Scientific Ltd. DOI: 10.1016/j.jprocont.2021.09.005 Waste biorefinery towards a sustainable biotechnological production of pediocin: Synergy between process simulation and environmental assessment Author(s): Ana Arias, Daniel Barreiro, Gumersindo Feijoo, Maria Teresa Moreira Published in: Environmental Technology & Innovation, 26, 2022, ISSN 2352-1864 Publisher: Elsevier BV DOI: 10.1016/j.eti.2022.102306 Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum Author(s): Oliver Goldbeck, Dominique N. Desef, Kirill V. Ovchinnikov, Fernando Perez-Garcia, Jens Christmann, Peter Sinner, Peter Crauwels, Dominik Weixler, Peng Cao, Judith Becker, Michael Kohlstedt, Julian Kager, Bernhard J. Eikmanns, Gerd M. Seibold, Christoph Herwig, Christoph Wittmann, Nadav S. Bar, Dzung B. Diep, Christian U. Riedel Published in: Metabolic Engineering, 2021, ISSN 1096-7176 Publisher: Academic Press DOI: 10.1016/j.ymben.2021.09.002 Inventory review and environmental evaluation of first- and second-generation sugars through life cycle assessment. Author(s): Sara Bello; Iana Salim; Gumersindo Feijoo; Maria Teresa Moreira Published in: Environmental Science and Pollution Research, 3, 2021, ISSN 0944-1344 Publisher: Springer Verlag DOI: 10.1007/s11356-021-12405-y Dynamic Co-Cultivation Process of Corynebacterium glutamicum Strains for the Fermentative Production of Riboflavin Author(s): Fernando Pérez-García, Arthur Burgardt, Dina R. Kallman, Volker F. Wendisch, Nadav Bar Published in: Fermentation, 7/1, 2021, Page(s) 11, ISSN 2311-5637 Publisher: MDPI DOI: 10.3390/fermentation7010011 In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium Author(s): Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel Published in: Microorganisms, 9/3, 2021, Page(s) 646, ISSN 2076-2607 Publisher: MDPI DOI: 10.3390/microorganisms9030646 Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being Author(s): Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann Published in: Essays in Biochemistry, 2021, ISSN 0071-1365 Publisher: Portland Press, Ltd. DOI: 10.1042/ebc20200134 The use of maize stover and sugar beet pulp as feedstocks in industrial fermentation plants – An economic and environmental perspective Author(s): Iana Câmara-Salim; Pablo Conde; Gumersindo Feijoo; Maria Teresa Moreira Published in: Cleaner Environmental Systems, 3, 2021, ISSN 2666-7894 Publisher: Elsevier DOI: 10.1016/j.cesys.2020.100005 Technological feasibility and environmental assessment of polylactic acid-nisin-based active packaging. Author(s): Arias, A., Feijoo, G. & Moreira, M.T. Published in: Sustainable Materials and Technologies, 2022, ISSN 2214-9937 Publisher: Elsevier DOI: 10.1016/j.susmat.2022.e00460 Linking process and metabolic modelling for the estimation of carbon flux distribution in Corynebacterium glutamicum growth in spent sulfite liquor Author(s): Pedro A.Lira-Parada, PeterSinner, MichaelKohlstedt, JulianKager, ChristophWittmann, ChristophHerwig, NadavBar Published in: IFAC-PapersOnLine, 2022, ISSN 2405-8963 Publisher: Elsevier DOI: 10.1016/j.ifacol.2022.07.449 BECCS based on bioethanol from wood residues: Potential towards a carbon-negative transport and side-effects Author(s): Sara Bello, Ángel Galán-Martín, Gumersindo Feijoo, Maria Teresa Moreira, Gonzalo Guillén-Gosálbez Published in: Applied Energy, 279, 2020, Page(s) 115884, ISSN 0306-2619 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.apenergy.2020.115884 Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty Author(s): Peter Sinner, Marlene Stiegler, Christoph Herwig, Julian Kager Published in: Bioresource Technology, 321, 2021, Page(s) 124395, ISSN 0960-8524 Publisher: Elsevier BV DOI: 10.1016/j.biortech.2020.124395 The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution Author(s): Ingvild S. Reinseth, Kirill V. Ovchinnikov, Hanne H. Tønnesen, Harald Carlsen, Dzung B. Diep Published in: Probiotics and Antimicrobial Proteins, 2019, ISSN 1867-1306 Publisher: Springer Pub. Co., DOI: 10.1007/s12602-019-09618-6 Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste Author(s): Peter Sinner, Julian Kager, Sven Daume, Christoph Herwig Published in: IFAC-PapersOnLine, 2019, ISSN 2405-8963 Publisher: Elsevier The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations Author(s): Fabian Stefan Franz Hartmann, Lina Clermont, Quach Ngoc Tung, Haike Antelmann, Gerd Michael Seibold Published in: Antioxidants, 9/10, 2020, Page(s) 969, ISSN 2076-3921 Publisher: MDPI DOI: 10.3390/antiox9100969 Establishing the multi-criteria roadmap and metrics for the evaluation of active films for food packaging Author(s): Arias, A., Feijoo, G., & Moreira, M. T. Published in: Current Research in Green and Sustainable Chemistry, 4, 2021, ISSN 2666-0865 Publisher: Elsevier DOI: 10.1016/j.crgsc.2021.100160 Process and environmental simulation in the validation of the biotechnological production of nisin from waste Author(s): Arias, A., Feijoo, G., & Moreira, M. T. Published in: Biochemical Engineering Journal, 174, 2021, ISSN 1369-703X Publisher: Elsevier BV DOI: 10.1016/j.bej.2021.108105 Book chapters (2) Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess Author(s): Peter Sinner, Christoph Herwig, Julian Kager Published in: 30th European Symposium on Computer Aided Process Engineering, 48, 2020, Page(s) 1603-1608, ISBN 9780128233771 Publisher: Elsevier DOI: 10.1016/b978-0-12-823377-1.50268-8 Usage of Digital Twins Along a Typical Process Development Cycle Author(s): Peter Sinner, Sven Daume, Christoph Herwig, Julian Kager Published in: Digital Twins - Tools and Concepts for Smart Biomanufacturing, 176, 2021, Page(s) 71-96, ISBN 978-3-030-71659-2 Publisher: Springer International Publishing DOI: 10.1007/10_2020_149 Conference proceedings (1) EXTENDED KALMAN FILTER FOR SUGAR ESTIMATION USING COMBINED FREQUENT AND INFREQUENT MEASUREMENTS Author(s): Andrea Tuveri, Pedro LIra, Fernando Perez-Garcia, Nadav Bar Published in: IFAC FOSBE 19, 17th October 2019, 2019 Publisher: Elsevier Searching for OpenAIRE data... 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