Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways

Project Information

FitteR-CATABOLIC

Grant agreement ID: 785809

DOI 10.3030/785809

Project closed

EC signature date 22 August 2018

Start date 1 October 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Publications

Peer reviewed articles (37)

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Author(s): Gunst, Jan; Debaveye, Yves; Güiza, Fabian; Dubois, Jasperina; De Bruyn, Astrid; Dauwe, Dieter; De Troy, Erwin; Casaer, Michael P; De Vlieger, Greet; Haghedooren, Renata; Jacobs, Bart; Meyfroidt, Geert; Ingels, Catherine; Muller, Jan; Vlasselaers, Dirk; Desmet, Lars; Mebis, Liese; Wouters, Pieter J; Stessel, Björn; Geebelen, Laurien; Vandenbrande, Jeroen; Brands, Michiel; Gruyters, Ine; Geerts, E
Published in: The New England Journal of Medicine, Issue 389 (13), 2023, Page(s) 1180-1190, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2304855

Weakness in the ICU: the right weight on the right scale

Author(s): Nathalie Van Aerde, Greet Van den Berghe, Greet Hermans
Published in: Intensive Care Medicine, Issue 47/1, 2021, Page(s) 137-138, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-020-06274-1

Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit

Author(s): Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe
Published in: Critical Care, Issue 24/1, 2020, ISSN 1364-8535
Publisher: Biomed Central
DOI: 10.1186/s13054-020-03256-z

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients

Author(s): Jan Gunst, Astrid De Bruyn, Michael P. Casaer, Sarah Vander Perre, Lies Langouche, Greet Van den Berghe
Published in: Critical Care, Issue 25/1, 2021, ISSN 1364-8535
Publisher: Biomed Central
DOI: 10.1186/s13054-021-03772-6

Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial

Author(s): An Jacobs, Karolijn Dulfer, Renate D Eveleens, José Hordijk, Hanna Van Cleemput, Ines Verlinden, Pieter J Wouters, Liese Mebis, Gonzalo Garcia Guerra, Koen Joosten, Sascha C Verbruggen, Fabian Güiza, Ilse Vanhorebeek, Greet Van den Berghe
Published in: The Lancet Child & Adolescent Health, Issue 4/7, 2020, Page(s) 503-514, ISSN 2352-4642
Publisher: Elsevier
DOI: 10.1016/s2352-4642(20)30104-8

Role of ketones, ketogenic diets and intermittent fasting in ICU.

Author(s): Jan Gunst; Michael P Casaer; Lies Langouche; Greet Van den Berghe
Published in: Curr Opin Crit Care, Issue 27(4), 2021, Page(s) 385-389, ISSN 1070-5295
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?

Author(s): Jan Gunst; Michael P. Casaer; Jean-Charles Preiser; Jean Reignier; Greet Van den Berghe
Published in: Critical Care, Issue 27, 2023, ISSN 1466-609X
Publisher: BioMed Central
DOI: 10.1186/s13054-023-04317-9

Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness

Author(s): Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Berghe; Lies Langouche
Published in: Scientific Reports, Issue 1, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-14961-w

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate.

Author(s): Chloë Goossens; Ruben Weckx; Sarah Derde; Sarah Vander Perre; Inge Derese; Paul P. Van Veldhoven; Bart Ghesquière; Greet Van den Berghe; Lies Langouche
Published in: Critical Care, Issue Vol 25, Iss 1, 2021, Page(s) Pp 1-12, ISSN 1466-609X
Publisher: BioMed Central
DOI: 10.1186/s13054-021-03688-1

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Author(s): Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe, Ilse Vanhorebeek
Published in: Clinical Epigenetics, Issue 12/1, 2020, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-020-00947-w

Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study.

Author(s): Nathalie Van Aerde; Philippe Meersseman; Yves Debaveye; Alexander Wilmer; Michael P Casaer; Jan Gunst; Joost Wauters; Pieter Wouters; Kaatje Goetschalckx; Rik Gosselink; Greet Van den Berghe; Greet Hermans
Published in: Intensive Care Medicine, Issue 47/12), 2021, Page(s) 1462-1471, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-021-06541-9

Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model

Author(s): Chloë Goossens, Ruben Weckx, Sarah Derde, Lawrence Van Helleputte, Dominik Schneidereit, Michael Haug, Barbara Reischl, Oliver Friedrich, Ludo Van Den Bosch, Greet Van den Berghe, Lies Langouche
Published in: Journal of Cachexia, Sarcopenia and Muscle, 2021, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12668

The GH Axis in Relation to Accepting an Early Macronutrient Deficit and Outcome of Critically Ill Patients

Author(s): Lisa Van Dyck, Inge Derese, Sarah Vander Perre, Pieter J Wouters, Michaël P Casaer, Greet Hermans, Greet Van den Berghe, Ilse Vanhorebeek
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 104/11, 2019, Page(s) 5507-5518, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/jc.2019-00842

Role of ketones, ketogenic diets and intermittent fasting in ICU

Author(s): Jan Gunst, Michael P. Casaer, Lies Langouche, Greet Van den Berghe
Published in: Current Opinion in Critical Care, Issue 27/4, 2021, Page(s) 385-389, ISSN 1070-5295
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients.

Author(s): Jan Gunst; Astrid De Bruyn; Michael P Casaer; Sarah Vander Perre; Lies Langouche; Greet Van den Berghe
Published in: Critical Care, Issue Vol 25, Iss 1, 2021, Page(s) Pp 1-8, ISSN 1466-609X
Publisher: BioMed Central
DOI: 10.1186/s13054-021-03772-6

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

Author(s): Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe, Lies Langouche
Published in: Critical Care, Issue 25/1, 2021, ISSN 1364-8535
Publisher: Biomed Central
DOI: 10.1186/s13054-021-03688-1

Early Supplemental Parenteral Nutrition in Critically Ill Children: An Update

Author(s): An Jacobs, Ines Verlinden, Ilse Vanhorebeek, Greet Van den Berghe
Published in: Journal of Clinical Medicine, Issue 8/6, 2019, Page(s) 830, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8060830

"The clinical potential of GDF15 as a ""ready-to-feed indicator"" for critically ill adults"

Author(s): Lisa Van Dyck, Jan Gunst, Michael P Casaer, Bram Peeters, Inge Derese, Pieter J Wouters, Francis de Zegher, Ilse Vanhorebeek, Greet Van den Berghe
Published in: Critical Care, 2020, ISSN 1466-609X
Publisher: BioMed Central
DOI: 10.1186/s13054-020-03254-1

Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?

Author(s): Greet Van den Berghe; Jan Gunst; Lies Langouche
Published in: Critical Care, Issue Vol 25, Iss 1, 2021, Page(s) Pp 1-3, ISSN 1466-609X
Publisher: BioMed Central
DOI: 10.1186/s13054-021-03861-6

Effect of late versus early initiation of parenteral nutrition on weight deterioration during PICU stay: Secondary analysis of the PEPaNIC randomised controlled trial

Author(s): E. van Puffelen, J.M. Hulst, I. Vanhorebeek, K. Dulfer, G. Van den Berghe, K.F.M. Joosten, S.C.A.T. Verbruggen
Published in: Clinical Nutrition, 2019, ISSN 0261-5614
Publisher: Churchill Livingstone
DOI: 10.1016/j.clnu.2019.02.014

Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care

Author(s): Esther van Puffelen, Jessie M. Hulst, Ilse Vanhorebeek, Karolijn Dulfer, Greet Van den Berghe, Sascha C. A. T. Verbruggen, Koen F. M. Joosten
Published in: JAMA Network Open, Issue 1/5, 2018, Page(s) e182668, ISSN 2574-3805
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2018.2668

Glucose control in the ICU

Author(s): Jan Gunst, Astrid De Bruyn, Greet Van den Berghe
Published in: Current Opinion in Anaesthesiology, Issue 32/2, 2019, Page(s) 156-162, ISSN 0952-7907
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ACO.0000000000000706

Paediatric critical care survival: how to avoid bias

Author(s): Greet Van den Berghe
Published in: The Lancet Respiratory Medicine, Issue 7/2, 2019, Page(s) e2, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/S2213-2600(18)30408-9

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

Author(s): Chloë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe, Lies Langouche
Published in: Critical Care, Issue 23/1, 2019, Page(s) 236, ISSN 1364-8535
Publisher: Springer Nature
DOI: 10.1186/s13054-019-2506-6

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Author(s): Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, Eric Baugé, Yann Deleye, Dieter Mesotten, Lies Langouche, Jonathan Vanhoutte, Céline Cudejko, Kristiaan Wouters, Sarah Anissa Hannou, Vanessa Legry, Steve Lancel, Fanny Lalloyer, Arnaud Polizzi, Sarra Smati, Pierre Gourdy, Emmanuelle Vallez, Emmanuel Bouchaert, Bruno Derudas, Hélène Dehondt, Céline Gheeraert, Sébastien Fleury, Anne Tailleux,
Published in: Journal of Hepatology, Issue 70/5, 2019, Page(s) 963-973, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.12.037

Effect of early parenteral nutrition during paediatric critical illness on DNA methylation as a potential mediator of impaired neurocognitive development: a pre-planned secondary analysis of the PEPaNIC international randomised controlled trial

Author(s): Fabian Güiza, Ilse Vanhorebeek, Sören Verstraete, Ines Verlinden, Inge Derese, Catherine Ingels, Karolijn Dulfer, Sascha C Verbruggen, Gonzalo Garcia Guerra, Koen F Joosten, Pieter J Wouters, Greet Van den Berghe
Published in: The Lancet Respiratory Medicine, Issue 8/3, 2020, Page(s) 288-303, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/S2213-2600(20)30046-1

Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study

Author(s): Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P. Casaer, Frans Bruyninckx, Pieter J. Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Published in: Intensive Care Medicine, 2020, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-020-05927-5

ICU-acquired weakness

Author(s): Ilse Vanhorebeek, Nicola Latronico, Greet Van den Berghe
Published in: Intensive Care Medicine, Issue 46/4, 2020, Page(s) 637-653, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-020-05944-4

Intermittent Fasting

Author(s): Jan Gunst, Greet Van den Berghe, Michael P. Casaer
Published in: Chest, Issue 158/6, 2020, Page(s) 2707, ISSN 0012-3692
Publisher: American College of Chest Physicians
DOI: 10.1016/j.chest.2020.07.071

Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study

Author(s): Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P Casaer, Joost Wauters, Pieter J Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Published in: Thorax, 2021, Page(s) thoraxjnl-2020-216720, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216720

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study

Author(s): Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst, Michaël P. Casaer
Published in: Critical Care, Issue 24/1, 2020, ISSN 1364-8535
Publisher: Critical Care
DOI: 10.1186/s13054-020-02987-3

C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery.

Author(s): Catherine Ingels; Lies Langouche; Jasperina Dubois; Inge Derese; Sarah Vander Perre; Pieter Wouters; Jan Gunst; Michael P Casaer; Fabian Güiza; Ilse Vanhorebeek; Greet Van den Berghe
Published in: Intensive Care Medicine, Issue 48(1), 2022, Page(s) 25-35, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-021-06565-1

Five-year mortality and morbidity impact of prolonged versus brief ICU stay: a propensity score matched cohort study

Author(s): Greet Hermans, Nathalie Van Aerde, Philippe Meersseman, Helena Van Mechelen, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael Paul Casaer, Jasperina Dubois, Pieter Wouters, Rik Gosselink, Greet Van den Berghe
Published in: Thorax, Issue 74/11, 2019, Page(s) 1037-1045, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-213020

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome

Author(s): Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst, Greet Van den Berghe
Published in: Critical Care, Issue 25/1, 2021, ISSN 1364-8535
Publisher: Biomed Central
DOI: 10.1186/s13054-021-03519-3

Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice.

Author(s): Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Bergh; Lies Langouche
Published in: BMC Pharmacology and Toxicology, Issue Vol 22, Iss 1, 2021, Page(s) Pp 1-13, ISSN 2050-6511
Publisher: BioMed Central
DOI: 10.1186/s40360-021-00517-7

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin.

Author(s): Wouter Vankrunkelsven; Sarah Derde; Jan Gunst; Sarah Vander Perre; Emiel Declerck; Lies Pauwels; Inge Derese; Greet Van den Berghe; Lies Langouche
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue Vol 13, Iss 1, 2022, Page(s) 418-433, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12904

Intensive Care Nutrition and Post–Intensive Care Recovery

Author(s): Jan Gunst, Greet Van den Berghe
Published in: Critical Care Clinics, Issue 34/4, 2018, Page(s) 573-583, ISSN 0749-0704
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ccc.2018.06.004