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A new generation of microbial expression hosts and tools for the production of biotherapeutics and high-value enzymes

Objective

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.
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Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN

Address

Hanzeplein 1
9713 Gz Groningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 531 239,76

Participants (10)

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UNIVERSITY OF KENT

United Kingdom

EU Contribution

€ 606 345,12

OULUN YLIOPISTO

Finland

EU Contribution

€ 561 611,52

UNIVERSITAET GREIFSWALD

Germany

EU Contribution

€ 252 788,40

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany

EU Contribution

€ 252 788,40

ACIB GmbH

Austria

EU Contribution

€ 528 414,48

LONZA AG

Switzerland

EU Contribution

€ 281 276,64

AB Enzymes GmbH

Germany

EU Contribution

€ 252 788,40

UCB PHARMA SA

Belgium

EU Contribution

€ 303 172,56

BOEHRINGER INGELHEIM RCV GMBH & CO KG

Austria

EU Contribution

€ 264 207,24

UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS

Germany

EU Contribution

€ 252 788,40

Partners (4)

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Gedeon Richter Plc.

UNIVERSITAET FUER BODENKULTUR WIEN

POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH

BIOMIN HOLDING GMBH

Project information

Grant agreement ID: 813979

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 087 420,92

  • EU contribution

    € 4 087 420,92

Coordinated by:

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands