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A new generation of microbial expression hosts and tools for the production of biotherapeutics and high-value enzymes

Objective

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/biological sciences/synthetic biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 531 239,76

Participants (11)

UNIVERSITY OF KENT
United Kingdom
EU contribution
€ 606 345,12
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent
Activity type
Higher or Secondary Education Establishments
OULUN YLIOPISTO
Finland
EU contribution
€ 561 611,52
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 252 788,40
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 252 788,40
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
ACIB GMBH
Austria
EU contribution
€ 528 414,48
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
LONZA AG
Switzerland
EU contribution
€ 281 276,64
Address
Muenchensteinerstrasse 38
4002 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AB Enzymes GmbH
Germany
EU contribution
€ 252 788,40
Address
Feldbergstrasse 78
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB PHARMA SA

Participation ended

Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOEHRINGER INGELHEIM RCV GMBH & CO KG
Austria
EU contribution
€ 264 207,24
Address
Dr Boehringer Gasse 5-11
1121 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS
Germany
EU contribution
€ 252 788,40
Address
Fleischmannstrasse 8
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
CELLTECH R&D LIMITED
United Kingdom
EU contribution
€ 303 172,56
Address
208 Bath Road
SL1 3WE Slough
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

Gedeon Richter Plc.
Hungary
Address
Gyomroi Str 19-21
H1103 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET FUER BODENKULTUR WIEN
Austria
Address
Gregor Mendel Strasse 33
1180 Wien
Activity type
Higher or Secondary Education Establishments
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
Address
Donaustrasse 99
3400 Klosterneuburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMIN HOLDING GMBH
Austria
Address
Erber Campus 1
3131 Getzersdorf Bei Traismauer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)