CORDIS
EU research results

CORDIS

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automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy

Project information

Grant agreement ID: 823958

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 214 400

  • EU contribution

    € 1 214 400

Coordinated by:

ASTON UNIVERSITY

United Kingdom

Objective

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures.
During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE).
HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.
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Coordinator

ASTON UNIVERSITY

Address

Aston Triangle
B4 7et Birmingham

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 276 000

Participants (11)

STICHTING VUMC

Netherlands

EU Contribution

€ 4 600

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 13 800

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Greece

EU Contribution

€ 165 600

POLYTECHNEIO KRITIS

Greece

EU Contribution

€ 73 600

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

Italy

EU Contribution

€ 128 800

AAI SCIENTIFIC CULTURAL SERVICES LIMITED

Cyprus

EU Contribution

€ 193 200

BRAINSIGNS SRL

Italy

EU Contribution

€ 110 400

G.TEC MEDICAL ENGINEERING GMBH

Austria

EU Contribution

€ 105 800

INSTITOYTO BIOIATPIKHE TEXNOLOGIAS

Greece

EU Contribution

€ 59 800

YORK INSTRUMENTS LTD

United Kingdom

EU Contribution

€ 82 800

BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST

United Kingdom

Partners (1)

CHILDREN'S HOSPITAL CORPORATION

United States

Project information

Grant agreement ID: 823958

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 214 400

  • EU contribution

    € 1 214 400

Coordinated by:

ASTON UNIVERSITY

United Kingdom