Advanced gene-editing tools for safer gene therapy
Gene therapy offers a promising approach to treat incurable diseases by silencing, activating or recoding specific genes. In addition to conventional gene transfer strategies, newly emerged gene-editing technologies provide the potential for precise manipulation of the genome. The EU-funded UPGRADE project aims to address certain gene therapy limitations associated with insertional mutagenesis, off-target effects, or limited efficiency. Researchers will develop disruptive new technologies for precision gene and epigenome editing, as well as for gene insertion. Following stringent validation, the project will lead to advanced medicinal products and versatile tools that could be used for a number of diseases.
Fields of science
Call for proposal
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