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Unlocking Precision Gene Therapy

Project description

Advanced gene-editing tools for safer gene therapy

Gene therapy offers a promising approach to treat incurable diseases by silencing, activating or recoding specific genes. In addition to conventional gene transfer strategies, newly emerged gene-editing technologies provide the potential for precise manipulation of the genome. The EU-funded UPGRADE project aims to address certain gene therapy limitations associated with insertional mutagenesis, off-target effects, or limited efficiency. Researchers will develop disruptive new technologies for precision gene and epigenome editing, as well as for gene insertion. Following stringent validation, the project will lead to advanced medicinal products and versatile tools that could be used for a number of diseases.

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
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Coordinator

FONDAZIONE TELETHON
Address
Via Varese 16/B
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 4 952 968,75

Participants (7)

UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 2 767 377,50
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI TRENTO
Italy
EU contribution
€ 1 333 798,75
Address
Via Calepina 14
38122 Trento
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 1 107 000
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 1 328 412,50
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE NANTES
France
EU contribution
€ 1 182 500
Address
Quai De Tourville 1
44035 Nantes Cedex 1
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 1 106 062,50
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
THE GENERAL HOSPITAL CORPORATION
United States
EU contribution
€ 1 217 710
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other