Deciphering and predicting the evolution of cancer cell populations

Project Information

CANCEREVO

Grant agreement ID: 820137

DOI 10.3030/820137

EC signature date 23 January 2019

Start date 1 March 2019

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Publications

Peer reviewed articles (5)

Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer

Author(s): Andrew Woolston, Louise J. Barber, Beatrice Griffiths, Oriol Pich, Nuria Lopez-Bigas, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, Naureen Starling, David Cunningham, Marco Gerlinger
Published in: Nature Ecology & Evolution, Issue 5/7, 2021, Page(s) 1024-1032, ISSN 2397-334X
Publisher: Nature Ecology and Evolution
DOI: 10.1038/s41559-021-01470-8

Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

Author(s): Franciele H. Knebel, Louise J. Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca, Frederico Costa, Fernanda Cunha Capareli, Paulo M. Hoff, Jorge Sabbaga, Anamaria A. Camargo, Marco Gerlinger
Published in: Cancers, Issue 12/12, 2020, Page(s) 3736, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123736

Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma

Author(s): Michael Davidson, Louise J. Barber, Andrew Woolston, Catherine Cafferkey, Sonia Mansukhani, Beatrice Griffiths, Sing-Yu Moorcraft, Isma Rana, Ruwaida Begum, Ioannis Assiotis, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, David Cunningham, Naureen Starling, Marco Gerlinger
Published in: Cancers, Issue 11/5, 2019, Page(s) 736, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11050736

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

Author(s): Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J. Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J. Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-Sternberg, Marco Gerlinger
Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426
Publisher: Biomedcentral
DOI: 10.1186/s40425-019-0769-8

Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes

Author(s): Benjamin R Challoner, Katharina von Loga, Andrew Woolston, Beatrice Griffiths, Nanna Sivamanoharan, Maria Semiannikova, Alice Newey, Louise J Barber, David Mansfield, Lindsay C Hewitt, Yuichi Saito, Naser Davarzani, Naureen Starling, Alan Melcher, Heike I Grabsch, Marco Gerlinger
Published in: JNCI: Journal of the National Cancer Institute, Issue monthly, 2020, ISSN 0027-8874
Publisher: Oxford University Press
DOI: 10.1093/jnci/djaa051